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Note 6 - Share-based Compensation - Noncash Stock Option Compensation (Details) - USD ($) | 12 Months Ended
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Dec. 31, 2024 | Dec. 31, 2023
Stock-based compensation | $ 1,126,279 | $ 1,244,121
Share-based compensation expenses | 1,126,279 | 1,244,121
Share-Based Payment Arrangement, Option [Member] |  |
Stock-based compensation | 861,999 | 1,004,054
Share-based compensation expenses | 861,999 | 1,004,054
Restricted Stock Units (RSUs) [Member] |  |
Stock-based compensation | 264,280 | 240,067
Share-based compensation expenses | 264,280 | 240,067
General and Administrative Expense [Member] |  |
Stock-based compensation | (1,067,750) | (1,201,027)
Share-based compensation expenses | (1,067,750) | (1,201,027)
Research and Development Expense [Member] |  |
Stock-based compensation | 58,529 | 43,094
Share-based compensation expenses | $ 58,529 | $ 43,094

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- Definition Amount of expense for award under share-based payment arrangement. Excludes amount capitalized. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 14.F) -Publisher FASB -URI https://asc.fasb.org/1943274/2147479830/718-10-S99-1 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (h)(1)(i) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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