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Note 1 - Organization and Summary of Significant Accounting Policies (Details Textual) |  |  | 1 Months Ended | 12 Months Ended |  |  |
--- | --- | --- | --- | --- | --- | --- | ---
Nov. 16, 2024 USD ($) | Mar. 08, 2024 USD ($) | Aug. 31, 2023 | Dec. 31, 2024 USD ($) shares | Dec. 31, 2023 USD ($) shares | Nov. 30, 2024 USD ($) | Oct. 04, 2024 $ / shares | Oct. 03, 2024 $ / shares
Debt Conversion, Original Debt, Amount |  |  |  | $ 910,000 | $ 0 |  |  |
Cash and Cash Equivalents, at Carrying Value |  |  |  | 6,506,750 | 6,515,028 |  |  |
Short-Term Investments |  |  |  | 2,780,825 |  |  |  |
Cash, Cash Equivalents, and Short-Term Investments |  |  |  | $ 9,287,575 | 7,300,000 |  |  |
Number of Operating Segments |  |  |  | 1 |  |  |  |
Revenue from Contract with Customer, Excluding Assessed Tax |  |  |  | $ 3,495,389 | 2,898,806 |  |  |
Restricted Cash |  |  |  | 0 | 0 |  |  |
Accounts Receivable, Allowance for Credit Loss |  |  |  | 0 | 0 |  |  |
Operating Lease, Expense |  |  |  | 106,785 | 71,656 |  |  |
Operating Lease, Liability |  |  |  | 88,870 | 136,929 |  |  |
Lessee, Operating Lease, Liability, Undiscounted Excess Amount |  |  |  | 6,669 | 16,770 |  |  |
Operating Lease, Right-of-Use Asset |  |  |  | $ 92,211 | $ 141,439 |  |  |
Operating Lease, Weighted Average Remaining Lease Term (Year) |  |  |  | 1 year 8 months 12 days |  |  |  |
Operating Lease, Weighted Average Discount Rate, Percent |  |  |  | 8.80% |  |  |  |
Share-Based Payment Arrangement, Option [Member] |  |  |  |  |  |  |  |
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount (in shares) | shares |  |  |  | 5,788,597 | 5,469,247 |  |  |
The 1044 N Lease [Member] |  |  |  |  |  |  |  |
Lessee Operating Lease Yearly Percentage Increase |  |  | 3.00% |  |  |  |  |
Lessee, Operating Lease, Term of Contract (Year) |  |  | 3 years |  |  |  |  |
Lessee Operating Lease Additional Number of Renewal Terms |  |  | 2 |  |  |  |  |
Lessee, Operating Lease, Renewal Term (Year) |  |  | 1 year |  |  |  |  |
Customer Concentration Risk [Member] | Revenue Benchmark [Member] |  |  |  |  |  |  |  |
Concentration Risk, Number of Customers |  |  |  | 19 | 16 |  |  |
Customer Concentration Risk [Member] | Revenue Benchmark [Member] | Non-US [Member] |  |  |  |  |  |  |  |
Concentration Risk, Number of Customers |  |  |  | 11 | 6 |  |  |
Customer Concentration Risk [Member] | Revenue Benchmark [Member] | Two Significant Customers [Member] |  |  |  |  |  |  |  |
Concentration Risk, Number of Customers |  |  |  |  | 2 |  |  |
Concentration Risk, Significant Customers |  |  |  | 2 |  |  |  |
Revenue from Contract with Customer, Excluding Assessed Tax |  |  |  | $ 1,915,000 | $ 1,503,000 |  |  |
Concentration Risk, Percentage |  |  |  | 54.80% | 51.90% |  |  |
Customer Concentration Risk [Member] | Revenue Benchmark [Member] | Eleven Significant Customers [Member] | Non-US [Member] |  |  |  |  |  |  |  |
Revenue from Contract with Customer, Excluding Assessed Tax |  |  |  | $ 1,526,000 |  |  |  |
Concentration Risk, Percentage |  |  |  | 43.70% |  |  |  |
Customer Concentration Risk [Member] | Revenue Benchmark [Member] | Six Significant Customers [Member] | Non-US [Member] |  |  |  |  |  |  |  |
Revenue from Contract with Customer, Excluding Assessed Tax |  |  |  |  | $ 537,000 |  |  |
Concentration Risk, Percentage |  |  |  |  | 18.50% |  |  |
Customer Concentration Risk [Member] | Accounts Receivable [Member] |  |  |  |  |  |  |  |
Concentration Risk, Number of Customers |  |  |  | 9 | 13 |  |  |
Customer Concentration Risk [Member] | Accounts Receivable [Member] | Non-US [Member] |  |  |  |  |  |  |  |
Concentration Risk, Number of Customers |  |  |  | 4 | 6 |  |  |
Customer Concentration Risk [Member] | Accounts Receivable [Member] | Six Significant Customers [Member] | Non-US [Member] |  |  |  |  |  |  |  |
Concentration Risk, Percentage |  |  |  |  | 45.60% |  |  |
Accounts Receivable, after Allowance for Credit Loss |  |  |  |  | $ 213,000 |  |  |
Customer Concentration Risk [Member] | Accounts Receivable [Member] | Four Significant Customers [Member] | Non-US [Member] |  |  |  |  |  |  |  |
Concentration Risk, Percentage |  |  |  | 61.50% |  |  |  |
Accounts Receivable, after Allowance for Credit Loss |  |  |  | $ 146,000 |  |  |  |
Supplier Concentration Risk [Member] | Contract Research Organizations [Member] | Two CROs [Member] |  |  |  |  |  |  |  |
Concentration Risk, Percentage |  |  |  | 93.00% |  |  |  |
Concentration Risk, Number of Suppliers |  |  |  | 2 |  |  |  |
Research Services Purchased |  |  |  | $ 2,389,000 |  |  |  |
Supplier Concentration Risk [Member] | Contract Research Organizations [Member] | Three CROs [Member] |  |  |  |  |  |  |  |
Concentration Risk, Percentage |  |  |  |  | 96.00% |  |  |
Concentration Risk, Number of Suppliers |  |  |  |  | 3 |  |  |
Research Services Purchased |  |  |  |  | $ 4,644,000 |  |  |
Supplier Concentration Risk [Member] | Accounts Payable [Member] | Three CROs [Member] |  |  |  |  |  |  |  |
Concentration Risk, Percentage |  |  |  |  | 94.40% |  |  |
Accounts Payable |  |  |  |  | $ 620,000 |  |  |
Supplier Concentration Risk [Member] | Accounts Payable [Member] | Two CROs [Member] |  |  |  |  |  |  |  |
Concentration Risk, Percentage |  |  |  | 58.90% |  |  |  |
Concentration Risk, Number of Suppliers |  |  |  | 2 |  |  |  |
Accounts Payable |  |  |  | $ 284,000 |  |  |  |
Supplier Concentration Risk [Member] | Accounts Payable [Member] | Three CROs [Member] |  |  |  |  |  |  |  |
Concentration Risk, Number of Suppliers |  |  |  |  | 3 |  |  |
Gates Foundation [Member] |  |  |  |  |  |  |  |
Proceeds from Grantors | $ 3,092,136 |  |  |  |  |  |  |
Accounts Receivable, after Allowance for Credit Loss |  |  |  |  |  | $ 3,092,136 |  |
Conversion Of Convertible Notes Into Common Stock [Member] |  |  |  |  |  |  |  |
Debt Conversion, Original Debt, Amount |  |  |  | $ 910,000 |  |  |  |
Debt Conversion, Converted Instrument, Shares Issued (in shares) | shares |  |  |  | 556,623 |  |  |  |
Senior Secured 2024 Notes [Member] |  |  |  |  |  |  |  |
Debt Instrument, Face Amount |  | $ 6,000,000 |  |  |  |  |  |
Debt Instrument, Interest Rate, Stated Percentage |  | 8.00% |  | 8.00% |  |  |  |
Proceeds from Issuance of Senior Long-Term Debt |  | $ 5,824,326 |  |  |  |  |  |
Debt Instrument, Convertible, Conversion Price (in dollars per share) | $ / shares |  |  |  |  |  |  | $ 1.4 | $ 1.79

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