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Note 1 - Organization and Summary of Significant Accounting Policies (Details Textual)			1 Months Ended	12 Months Ended
	Nov. 16, 2024 USD ($)	Mar. 08, 2024 USD ($)	Aug. 31, 2023	Dec. 31, 2024 USD ($) shares	Dec. 31, 2023 USD ($) shares	Nov. 30, 2024 USD ($)	Oct. 04, 2024 $ / shares	Oct. 03, 2024 $ / shares
Debt Conversion, Original Debt, Amount				$ 910,000	$ 0
Cash and Cash Equivalents, at Carrying Value				6,506,750	6,515,028
Short-Term Investments				2,780,825
Cash, Cash Equivalents, and Short-Term Investments				$ 9,287,575	7,300,000
Number of Operating Segments				1
Revenue from Contract with Customer, Excluding Assessed Tax				$ 3,495,389	2,898,806
Restricted Cash				0	0
Accounts Receivable, Allowance for Credit Loss				0	0
Operating Lease, Expense				106,785	71,656
Operating Lease, Liability				88,870	136,929
Lessee, Operating Lease, Liability, Undiscounted Excess Amount				6,669	16,770
Operating Lease, Right-of-Use Asset				$ 92,211	$ 141,439
Operating Lease, Weighted Average Remaining Lease Term (Year)				1 year 8 months 12 days
Operating Lease, Weighted Average Discount Rate, Percent				8.80%
Share-Based Payment Arrangement, Option [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount (in shares) | shares				5,788,597	5,469,247
The 1044 N Lease [Member]
Lessee Operating Lease Yearly Percentage Increase			3.00%
Lessee, Operating Lease, Term of Contract (Year)			3 years
Lessee Operating Lease Additional Number of Renewal Terms			2
Lessee, Operating Lease, Renewal Term (Year)			1 year
Customer Concentration Risk [Member] | Revenue Benchmark [Member]
Concentration Risk, Number of Customers				19	16
Customer Concentration Risk [Member] | Revenue Benchmark [Member] | Non-US [Member]
Concentration Risk, Number of Customers				11	6
Customer Concentration Risk [Member] | Revenue Benchmark [Member] | Two Significant Customers [Member]
Concentration Risk, Number of Customers					2
Concentration Risk, Significant Customers				2
Revenue from Contract with Customer, Excluding Assessed Tax				$ 1,915,000	$ 1,503,000
Concentration Risk, Percentage				54.80%	51.90%
Customer Concentration Risk [Member] | Revenue Benchmark [Member] | Eleven Significant Customers [Member] | Non-US [Member]
Revenue from Contract with Customer, Excluding Assessed Tax				$ 1,526,000
Concentration Risk, Percentage				43.70%
Customer Concentration Risk [Member] | Revenue Benchmark [Member] | Six Significant Customers [Member] | Non-US [Member]
Revenue from Contract with Customer, Excluding Assessed Tax					$ 537,000
Concentration Risk, Percentage					18.50%
Customer Concentration Risk [Member] | Accounts Receivable [Member]
Concentration Risk, Number of Customers				9	13
Customer Concentration Risk [Member] | Accounts Receivable [Member] | Non-US [Member]
Concentration Risk, Number of Customers				4	6
Customer Concentration Risk [Member] | Accounts Receivable [Member] | Six Significant Customers [Member] | Non-US [Member]
Concentration Risk, Percentage					45.60%
Accounts Receivable, after Allowance for Credit Loss					$ 213,000
Customer Concentration Risk [Member] | Accounts Receivable [Member] | Four Significant Customers [Member] | Non-US [Member]
Concentration Risk, Percentage				61.50%
Accounts Receivable, after Allowance for Credit Loss				$ 146,000
Supplier Concentration Risk [Member] | Contract Research Organizations [Member] | Two CROs [Member]
Concentration Risk, Percentage				93.00%
Concentration Risk, Number of Suppliers				2
Research Services Purchased				$ 2,389,000
Supplier Concentration Risk [Member] | Contract Research Organizations [Member] | Three CROs [Member]
Concentration Risk, Percentage					96.00%
Concentration Risk, Number of Suppliers					3
Research Services Purchased					$ 4,644,000
Supplier Concentration Risk [Member] | Accounts Payable [Member] | Three CROs [Member]
Concentration Risk, Percentage					94.40%
Accounts Payable					$ 620,000
Supplier Concentration Risk [Member] | Accounts Payable [Member] | Two CROs [Member]
Concentration Risk, Percentage				58.90%
Concentration Risk, Number of Suppliers				2
Accounts Payable				$ 284,000
Supplier Concentration Risk [Member] | Accounts Payable [Member] | Three CROs [Member]
Concentration Risk, Number of Suppliers					3
Gates Foundation [Member]
Proceeds from Grantors	$ 3,092,136
Accounts Receivable, after Allowance for Credit Loss						$ 3,092,136
Conversion Of Convertible Notes Into Common Stock [Member]
Debt Conversion, Original Debt, Amount				$ 910,000
Debt Conversion, Converted Instrument, Shares Issued (in shares) | shares				556,623
Senior Secured 2024 Notes [Member]
Debt Instrument, Face Amount		$ 6,000,000
Debt Instrument, Interest Rate, Stated Percentage		8.00%		8.00%
Proceeds from Issuance of Senior Long-Term Debt		$ 5,824,326
Debt Instrument, Convertible, Conversion Price (in dollars per share) | $ / shares							$ 1.4	$ 1.79

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