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Note 1 - Organization and Summary of Significant Accounting Policies - Research and Development Costs (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Outside contracted services $ 1,503,397 $ 2,677,941
Personnel related costs 473,444 553,741
Facilities, overhead and other 67,412 65,584
Research And Development Expense, Including Related Party $ 2,044,253 $ 3,297,266