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Note 1 - Organization and Summary of Significant Accounting Policies (Details Textual) |  |  | 3 Months Ended | 12 Months Ended |  |  |
--- | --- | --- | --- | --- | --- | --- | ---
Nov. 16, 2024 USD ($) | Mar. 08, 2024 USD ($) | Mar. 31, 2025 USD ($) shares | Mar. 31, 2024 USD ($) shares | Dec. 31, 2024 USD ($) | Mar. 20, 2025 USD ($) | Nov. 30, 2024 USD ($) | Oct. 04, 2024 $ / shares
Cash and Cash Equivalent |  |  | $ 5,064,941 |  | $ 6,506,750 |  |  |
Short-Term Investments |  |  | 2,307,685 |  |  |  |  |
Cash, Cash Equivalents, and Short-Term Investments |  |  | $ 7,349,413 |  | 9,300,000 |  |  |
Number of Operating Segments |  |  | 1 |  |  |  |  |
Revenue from Contract with Customer, Excluding Assessed Tax |  |  | $ 393,572 | $ 334,617 |  |  |  |
Accounts Receivable, Allowance for Credit Loss |  |  | 0 |  | 0 |  |  |
Deferred Tax Assets, Net |  |  | $ 19,100,000 |  | $ 17,600,000 |  |  |
Deferred Tax Assets, Valuation Allowance Coverage, Percent |  |  | 100.00% |  | 100.00% |  |  |
Share-Based Payment Arrangement [Member] |  |  |  |  |  |  |  |
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount (in shares) | shares |  |  | 6,401,581 | 6,100,857 |  |  |  |
Restricted Stock Units (RSUs) [Member] |  |  |  |  |  |  |  |
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount (in shares) | shares |  |  | 96,984 | 191,510 |  |  |  |
Share-Based Payment Arrangement, Option [Member] |  |  |  |  |  |  |  |
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount (in shares) | shares |  |  | 6,304,597 | 5,909,347 |  |  |  |
Customer Concentration Risk [Member] | Revenue Benchmark [Member] |  |  |  |  |  |  |  |
Concentration Risk, Number of Suppliers |  |  | 7 | 10 |  |  |  |
Customer Concentration Risk [Member] | Revenue Benchmark [Member] | Non-US [Member] |  |  |  |  |  |  |  |
Concentration Risk, Number of Customers |  |  | 1 | 8 |  |  |  |
Customer Concentration Risk [Member] | Revenue Benchmark [Member] | Four Significant Customers [Member] |  |  |  |  |  |  |  |
Concentration Risk, Significant Customers |  |  |  | 4 |  |  |  |
Revenue from Contract with Customer, Excluding Assessed Tax |  |  |  | $ 225,000 |  |  |  |
Concentration Risk, Percentage |  |  |  | 67.20% |  |  |  |
Customer Concentration Risk [Member] | Revenue Benchmark [Member] | Two Significant Customers [Member] |  |  |  |  |  |  |  |
Revenue from Contract with Customer, Excluding Assessed Tax |  |  | $ 350,000 |  |  |  |  |
Concentration Risk, Percentage |  |  | 89.00% |  |  |  |  |
Customer Concentration Risk [Member] | Revenue Benchmark [Member] | One Customer [Member] | Non-US [Member] |  |  |  |  |  |  |  |
Revenue from Contract with Customer, Excluding Assessed Tax |  |  | $ 48,000 |  |  |  |  |
Concentration Risk, Percentage |  |  | 65.80% |  |  |  |  |
Customer Concentration Risk [Member] | Revenue Benchmark [Member] | Eight Customers [Member] | Non-US [Member] |  |  |  |  |  |  |  |
Revenue from Contract with Customer, Excluding Assessed Tax |  |  |  | $ 274,000 |  |  |  |
Concentration Risk, Percentage |  |  |  | 81.80% |  |  |  |
Customer Concentration Risk [Member] | Accounts Receivable [Member] |  |  |  |  |  |  |  |
Concentration Risk, Number of Customers |  |  | 10 |  |  |  |  |
Customer Concentration Risk [Member] | Accounts Receivable [Member] | Non-US [Member] |  |  |  |  |  |  |  |
Revenue from Contract with Customer, Excluding Assessed Tax |  |  |  |  | $ 146,000 |  |  |
Concentration Risk, Percentage |  |  | 17.30% |  | 61.50% |  |  |
Concentration Risk, Number of Customers |  |  | 2 |  | 4 |  |  |
Accounts Receivable, after Allowance for Credit Loss |  |  | $ 39,000 |  |  |  |  |
Customer Concentration Risk [Member] | Accounts Receivable [Member] | Four Customers [Member] |  |  |  |  |  |  |  |
Revenue from Contract with Customer, Excluding Assessed Tax |  |  | $ 191,000 |  |  |  |  |
Concentration Risk, Percentage |  |  | 86.00% |  |  |  |  |
Concentration Risk, Number of Customers |  |  | 4 |  |  |  |  |
Customer Concentration Risk [Member] | Accounts Receivable [Member] | Three Customers [Member] |  |  |  |  |  |  |  |
Revenue from Contract with Customer, Excluding Assessed Tax |  |  |  |  | $ 146,000 |  |  |
Concentration Risk, Percentage |  |  |  |  | 61.50% |  |  |
Concentration Risk, Number of Customers |  |  |  |  | 4 |  |  |
Supplier Concentration Risk [Member] | Contract Research Organizations [Member] | Two CROs [Member] |  |  |  |  |  |  |  |
Concentration Risk, Number of Suppliers |  |  | 2 |  |  |  |  |
Concentration Risk, Percentage |  |  | 77.90% |  |  |  |  |
Research Services Purchased |  |  | $ 483,000 |  |  |  |  |
Supplier Concentration Risk [Member] | Contract Research Organizations [Member] | Three CROs [Member] |  |  |  |  |  |  |  |
Concentration Risk, Number of Suppliers |  |  |  | 3 |  |  |  |
Concentration Risk, Percentage |  |  |  | 81.40% |  |  |  |
Research Services Purchased |  |  |  | $ 359,000 |  |  |  |
Supplier Concentration Risk [Member] | Accounts Payable [Member] | Two CROs [Member] |  |  |  |  |  |  |  |
Concentration Risk, Number of Suppliers |  |  |  |  | 2 |  |  |
Concentration Risk, Percentage |  |  | 40.90% |  | 58.90% |  |  |
Accounts Payable |  |  | $ 184,000 |  | $ 284,000 |  |  |
Gates Foundation [Member] |  |  |  |  |  |  |  |
Proceeds from Grantors | $ 3,092,136 |  |  |  |  |  |  |
Revenue from Contract with Customer, Excluding Assessed Tax |  |  | 176,000 |  |  |  |  |
Accounts Receivable, after Allowance for Credit Loss |  |  |  |  |  |  | $ 3,092,136 |
CEPI [Member] |  |  |  |  |  |  |  |
Grant Receivable |  |  |  |  |  | $ 2,400,000 |  |
Revenue from Contract with Customer, Excluding Assessed Tax |  |  | 34,000 |  |  |  |  |
CEPI [Member] | Fondazione Biotecnopolo di Siena (FBS) [Member] |  |  |  |  |  |  |  |
Grant Receivable |  |  |  |  |  | $ 4,500,000 |  |
Conversion Of Convertible Notes Into Common Stock [Member] |  |  |  |  |  |  |  |
Debt Conversion, Original Debt, Amount |  |  | $ 910,000 |  |  |  |  |
Debt Conversion, Converted Instrument, Shares Issued (in shares) | shares |  |  | 556,623 |  |  |  |  |
Senior Secured 2024 Notes [Member] |  |  |  |  |  |  |  |
Debt Instrument, Face Amount |  | $ 6,000,000 |  |  |  |  |  |
Debt Instrument, Interest Rate, Stated Percentage |  | 8.00% | 8.00% |  |  |  |  |
Proceeds from Issuance of Senior Long-Term Debt |  | $ 5,824,000 |  |  |  |  |  |
Debt Instrument, Convertible, Conversion Price (in dollars per share) | $ / shares |  |  |  |  |  |  |  | $ 1.4

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