<?xml version="1.0" encoding="us-ascii" standalone="yes"?>
<!--XBRL Document Created with XBRLMaster-->
<!--Version: 2.3.08-->
<!--Based on XBRL 2.1-->
<!--Date of creation: 03/02/2023-->
<!--Software architectural design and coding: A'c Dharmapremananda Avt.-->
<!--Copyright (c) 2023 I-NET Business Solutions, Inc. All Rights Reserved.-->
<link:linkbase xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:link="http://www.xbrl.org/2003/linkbase" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://issuerdirect.com/role/Cover" xlink:href="isdr-20221231.xsd#Cover" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/ConsolidatedBalanceSheets" xlink:href="isdr-20221231.xsd#ConsolidatedBalanceSheets" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:href="isdr-20221231.xsd#ConsolidatedBalanceSheetsParenthetical" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/ConsolidatedStatementsOfOperationsUnaudited" xlink:href="isdr-20221231.xsd#ConsolidatedStatementsOfOperationsUnaudited" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/ConsolidatedStatementsOfComprehensiveIncomeUnaudited" xlink:href="isdr-20221231.xsd#ConsolidatedStatementsOfComprehensiveIncomeUnaudited" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/ConsolidatedStatementsOfStockholdersEquityUnaudited" xlink:href="isdr-20221231.xsd#ConsolidatedStatementsOfStockholdersEquityUnaudited" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/ConsolidatedStatementsOfCashFlowsUnaudited" xlink:href="isdr-20221231.xsd#ConsolidatedStatementsOfCashFlowsUnaudited" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/DescriptionBackgroundAndBasisOfOperations" xlink:href="isdr-20221231.xsd#DescriptionBackgroundAndBasisOfOperations" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/SummaryOfSignificantAccountingPolicies" xlink:href="isdr-20221231.xsd#SummaryOfSignificantAccountingPolicies" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/FixedAssets" xlink:href="isdr-20221231.xsd#FixedAssets" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/AcquisitionOfInewswireComLlc" xlink:href="isdr-20221231.xsd#AcquisitionOfInewswireComLlc" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/GoodwillAndOtherIntangibleAssets" xlink:href="isdr-20221231.xsd#GoodwillAndOtherIntangibleAssets" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/LineOfCredit" xlink:href="isdr-20221231.xsd#LineOfCredit" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/Equity" xlink:href="isdr-20221231.xsd#Equity" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/StockOptionsAndRestrictedStockUnits" xlink:href="isdr-20221231.xsd#StockOptionsAndRestrictedStockUnits" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/Leases" xlink:href="isdr-20221231.xsd#Leases" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/CommitmentsAndContingencies" xlink:href="isdr-20221231.xsd#CommitmentsAndContingencies" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/Revenues" xlink:href="isdr-20221231.xsd#Revenues" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/IncomeTaxes" xlink:href="isdr-20221231.xsd#IncomeTaxes" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/EmployeeBenefitPlans" xlink:href="isdr-20221231.xsd#EmployeeBenefitPlans" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/SummaryOfSignificantAccountingPoliciesPolicies" xlink:href="isdr-20221231.xsd#SummaryOfSignificantAccountingPoliciesPolicies" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/SummaryOfSignificantAccountingPoliciesTables" xlink:href="isdr-20221231.xsd#SummaryOfSignificantAccountingPoliciesTables" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/FixedAssetsTables" xlink:href="isdr-20221231.xsd#FixedAssetsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/AcquisitionOfInewswireComLlcTables" xlink:href="isdr-20221231.xsd#AcquisitionOfInewswireComLlcTables" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/GoodwillAndOtherIntangibleAssetsTables" xlink:href="isdr-20221231.xsd#GoodwillAndOtherIntangibleAssetsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/EquityTables" xlink:href="isdr-20221231.xsd#EquityTables" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/StockOptionsAndRestrictedStockUnitsTables" xlink:href="isdr-20221231.xsd#StockOptionsAndRestrictedStockUnitsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/LeasesTables" xlink:href="isdr-20221231.xsd#LeasesTables" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/RevenueTables" xlink:href="isdr-20221231.xsd#RevenueTables" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/IncomeTaxesTables" xlink:href="isdr-20221231.xsd#IncomeTaxesTables" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/SummaryOfSignificantAccountingPoliciesDetails" xlink:href="isdr-20221231.xsd#SummaryOfSignificantAccountingPoliciesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/SummaryOfSignificantAccountingPoliciesDetails1" xlink:href="isdr-20221231.xsd#SummaryOfSignificantAccountingPoliciesDetails1" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/SummaryOfSignificantAccountingPoliciesDetails2" xlink:href="isdr-20221231.xsd#SummaryOfSignificantAccountingPoliciesDetails2" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/SummaryOfSignificantAccountingPoliciesDetailsNarrative" xlink:href="isdr-20221231.xsd#SummaryOfSignificantAccountingPoliciesDetailsNarrative" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/FixedAssetsDetails" xlink:href="isdr-20221231.xsd#FixedAssetsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/FixedAssetsDetailsNarrative" xlink:href="isdr-20221231.xsd#FixedAssetsDetailsNarrative" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/AcquisitionOfInewswireComLlcDetails" xlink:href="isdr-20221231.xsd#AcquisitionOfInewswireComLlcDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/AcquisitionOfInewswireComLlcDetails1" xlink:href="isdr-20221231.xsd#AcquisitionOfInewswireComLlcDetails1" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/AcquisitionOfInewswireComLlcDetailsNarrative" xlink:href="isdr-20221231.xsd#AcquisitionOfInewswireComLlcDetailsNarrative" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/GoodwillAndOtherIntangibleAssetsDetails" xlink:href="isdr-20221231.xsd#GoodwillAndOtherIntangibleAssetsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/GoodwillAndOtherIntangibleAssetsDetails1" xlink:href="isdr-20221231.xsd#GoodwillAndOtherIntangibleAssetsDetails1" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/GoodwillAndOtherIntangibleAssetsDetailsNarrative" xlink:href="isdr-20221231.xsd#GoodwillAndOtherIntangibleAssetsDetailsNarrative" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/LineOfCreditDetailsNarrative" xlink:href="isdr-20221231.xsd#LineOfCreditDetailsNarrative" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/EquityDetails" xlink:href="isdr-20221231.xsd#EquityDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/EquityDetails1" xlink:href="isdr-20221231.xsd#EquityDetails1" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/EquityDetailsNarrative" xlink:href="isdr-20221231.xsd#EquityDetailsNarrative" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/StockOptionsAndRestrictedStockUnitsDetails" xlink:href="isdr-20221231.xsd#StockOptionsAndRestrictedStockUnitsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/StockOptionsAndRestrictedStockUnitsDetails1" xlink:href="isdr-20221231.xsd#StockOptionsAndRestrictedStockUnitsDetails1" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/StockOptionsAndRestrictedStockUnitsDetails2" xlink:href="isdr-20221231.xsd#StockOptionsAndRestrictedStockUnitsDetails2" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/StockOptionsAndRestrictedStockUnitsDetails3" xlink:href="isdr-20221231.xsd#StockOptionsAndRestrictedStockUnitsDetails3" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/StockOptionsAndRestrictedStockUnitsDetails4" xlink:href="isdr-20221231.xsd#StockOptionsAndRestrictedStockUnitsDetails4" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/StockOptionsAndRestrictedStockUnitsDetailsNarrative" xlink:href="isdr-20221231.xsd#StockOptionsAndRestrictedStockUnitsDetailsNarrative" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/LeasesDetails" xlink:href="isdr-20221231.xsd#LeasesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/LeasesDetails1" xlink:href="isdr-20221231.xsd#LeasesDetails1" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/LeasesDetailsNarrative" xlink:href="isdr-20221231.xsd#LeasesDetailsNarrative" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/RevenueDetails" xlink:href="isdr-20221231.xsd#RevenueDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/IncomeTaxesDetails" xlink:href="isdr-20221231.xsd#IncomeTaxesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/IncomeTaxesDetails1" xlink:href="isdr-20221231.xsd#IncomeTaxesDetails1" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/IncomeTaxesDetails2" xlink:href="isdr-20221231.xsd#IncomeTaxesDetails2" xlink:type="simple" />
  <link:roleRef roleURI="http://issuerdirect.com/role/EmployeeBenefitPlanDetailsNarrative" xlink:href="isdr-20221231.xsd#EmployeeBenefitPlanDetailsNarrative" xlink:type="simple" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/Cover" xlink:title="00000001 - Document - Document and Entity Information" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/ConsolidatedBalanceSheets" xlink:title="000002 - Statement - CONSOLIDATED BALANCE SHEETS">
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsCurrent" xlink:label="loc_us-gaapAssetsCurrent" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaapCashAndCashEquivalentsAtCarryingValue" />
    <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssetsCurrent" xlink:to="loc_us-gaapCashAndCashEquivalentsAtCarryingValue" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsReceivableNet" xlink:label="loc_us-gaapAccountsReceivableNet" />
    <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssetsCurrent" xlink:to="loc_us-gaapAccountsReceivableNet" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxReceivable" xlink:label="loc_us-gaapIncomeTaxReceivable" />
    <link:calculationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssetsCurrent" xlink:to="loc_us-gaapIncomeTaxReceivable" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherAssetsCurrent" xlink:label="loc_us-gaapOtherAssetsCurrent" />
    <link:calculationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssetsCurrent" xlink:to="loc_us-gaapOtherAssetsCurrent" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Assets" xlink:label="loc_us-gaapAssets" />
    <link:calculationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssets" xlink:to="loc_us-gaapAssetsCurrent" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CapitalizedComputerSoftwareNet" xlink:label="loc_us-gaapCapitalizedComputerSoftwareNet" />
    <link:calculationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssets" xlink:to="loc_us-gaapCapitalizedComputerSoftwareNet" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="loc_us-gaapPropertyPlantAndEquipmentNet" />
    <link:calculationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssets" xlink:to="loc_us-gaapPropertyPlantAndEquipmentNet" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseRightOfUseAsset" xlink:label="loc_us-gaapOperatingLeaseRightOfUseAsset" />
    <link:calculationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssets" xlink:to="loc_us-gaapOperatingLeaseRightOfUseAsset" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherAssetsNoncurrent" xlink:label="loc_us-gaapOtherAssetsNoncurrent" />
    <link:calculationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssets" xlink:to="loc_us-gaapOtherAssetsNoncurrent" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Goodwill" xlink:label="loc_us-gaapGoodwill" />
    <link:calculationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssets" xlink:to="loc_us-gaapGoodwill" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill" xlink:label="loc_us-gaapIntangibleAssetsNetExcludingGoodwill" />
    <link:calculationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssets" xlink:to="loc_us-gaapIntangibleAssetsNetExcludingGoodwill" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesCurrent" xlink:label="loc_us-gaapLiabilitiesCurrent" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsPayableCurrent" xlink:label="loc_us-gaapAccountsPayableCurrent" />
    <link:calculationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesCurrent" xlink:to="loc_us-gaapAccountsPayableCurrent" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedLiabilitiesCurrent" xlink:label="loc_us-gaapAccruedLiabilitiesCurrent" />
    <link:calculationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesCurrent" xlink:to="loc_us-gaapAccruedLiabilitiesCurrent" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedIncomeTaxesCurrent" xlink:label="loc_us-gaapAccruedIncomeTaxesCurrent" />
    <link:calculationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesCurrent" xlink:to="loc_us-gaapAccruedIncomeTaxesCurrent" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NotesPayable" xlink:label="loc_us-gaapNotesPayable" />
    <link:calculationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesCurrent" xlink:to="loc_us-gaapNotesPayable" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredRevenueCurrent" xlink:label="loc_us-gaapDeferredRevenueCurrent" />
    <link:calculationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesCurrent" xlink:to="loc_us-gaapDeferredRevenueCurrent" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Liabilities" xlink:label="loc_us-gaapLiabilities" />
    <link:calculationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilities" xlink:to="loc_us-gaapLiabilitiesCurrent" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="isdr-20221231.xsd#isdr_DeferredTaxLiabilityNoncurrent" xlink:label="loc_isdrDeferredTaxLiabilityNoncurrent" />
    <link:calculationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilities" xlink:to="loc_isdrDeferredTaxLiabilityNoncurrent" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent" xlink:label="loc_us-gaapOperatingLeaseLiabilityNoncurrent" />
    <link:calculationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilities" xlink:to="loc_us-gaapOperatingLeaseLiabilityNoncurrent" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaapStockholdersEquity" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockValue" xlink:label="loc_us-gaapPreferredStockValue" />
    <link:calculationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapStockholdersEquity" xlink:to="loc_us-gaapPreferredStockValue" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockValue" xlink:label="loc_us-gaapCommonStockValue" />
    <link:calculationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapStockholdersEquity" xlink:to="loc_us-gaapCommonStockValue" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdditionalPaidInCapital" xlink:label="loc_us-gaapAdditionalPaidInCapital" />
    <link:calculationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapStockholdersEquity" xlink:to="loc_us-gaapAdditionalPaidInCapital" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaapAccumulatedOtherComprehensiveIncomeLossNetOfTax" />
    <link:calculationArc order="24" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapStockholdersEquity" xlink:to="loc_us-gaapAccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsAccumulatedDeficit" xlink:label="loc_us-gaapRetainedEarningsAccumulatedDeficit" />
    <link:calculationArc order="25" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapStockholdersEquity" xlink:to="loc_us-gaapRetainedEarningsAccumulatedDeficit" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesAndStockholdersEquity" xlink:label="loc_us-gaapLiabilitiesAndStockholdersEquity" />
    <link:calculationArc order="26" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesAndStockholdersEquity" xlink:to="loc_us-gaapLiabilities" xlink:type="arc" weight="1" />
    <link:calculationArc order="27" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesAndStockholdersEquity" xlink:to="loc_us-gaapStockholdersEquity" xlink:type="arc" weight="1" />
  </link:calculationLink>
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:title="000003 - Statement - CONSOLIDATED BALANCE SHEETS (Parenthetical)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/ConsolidatedStatementsOfOperationsUnaudited" xlink:title="000004 - Statement - CONSOLIDATED STATEMENTS OF OPERATIONS (UNAUDITED)">
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GrossProfit" xlink:label="loc_us-gaapGrossProfit" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Revenues" xlink:label="loc_us-gaapRevenues" />
    <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapGrossProfit" xlink:to="loc_us-gaapRevenues" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CostOfRevenue" xlink:label="loc_us-gaapCostOfRevenue" />
    <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapGrossProfit" xlink:to="loc_us-gaapCostOfRevenue" xlink:type="arc" weight="-1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingExpenses" xlink:label="loc_us-gaapOperatingExpenses" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GeneralAndAdministrativeExpense" xlink:label="loc_us-gaapGeneralAndAdministrativeExpense" />
    <link:calculationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapOperatingExpenses" xlink:to="loc_us-gaapGeneralAndAdministrativeExpense" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SellingAndMarketingExpense" xlink:label="loc_us-gaapSellingAndMarketingExpense" />
    <link:calculationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapOperatingExpenses" xlink:to="loc_us-gaapSellingAndMarketingExpense" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentExpense" xlink:label="loc_us-gaapResearchAndDevelopmentExpense" />
    <link:calculationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapOperatingExpenses" xlink:to="loc_us-gaapResearchAndDevelopmentExpense" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DepreciationAndAmortization" xlink:label="loc_us-gaapDepreciationAndAmortization" />
    <link:calculationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapOperatingExpenses" xlink:to="loc_us-gaapDepreciationAndAmortization" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingIncomeLoss" xlink:label="loc_us-gaapOperatingIncomeLoss" />
    <link:calculationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapOperatingIncomeLoss" xlink:to="loc_us-gaapGrossProfit" xlink:type="arc" weight="1" />
    <link:calculationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapOperatingIncomeLoss" xlink:to="loc_us-gaapOperatingExpenses" xlink:type="arc" weight="-1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest" xlink:label="loc_us-gaapIncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestIncomeExpenseNet" xlink:label="loc_us-gaapInterestIncomeExpenseNet" />
    <link:calculationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapIncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest" xlink:to="loc_us-gaapInterestIncomeExpenseNet" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherIncome" xlink:label="loc_us-gaapOtherIncome" />
    <link:calculationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapIncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest" xlink:to="loc_us-gaapOtherIncome" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaapNetIncomeLoss" />
    <link:calculationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetIncomeLoss" xlink:to="loc_us-gaapIncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherNoncashIncomeTaxExpense" xlink:label="loc_us-gaapOtherNoncashIncomeTaxExpense" />
    <link:calculationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetIncomeLoss" xlink:to="loc_us-gaapOtherNoncashIncomeTaxExpense" xlink:type="arc" weight="-1" />
  </link:calculationLink>
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/ConsolidatedStatementsOfComprehensiveIncomeUnaudited" xlink:title="000005 - Statement - CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME (UNAUDITED)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/ConsolidatedStatementsOfStockholdersEquityUnaudited" xlink:title="000006 - Statement - CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (UNAUDITED)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/ConsolidatedStatementsOfCashFlowsUnaudited" xlink:title="000007 - Statement - CONSOLIDATED STATEMENTS OF CASH FLOWS (UNAUDITED)">
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:label="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProfitLoss" xlink:label="loc_us-gaapProfitLoss" />
    <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapProfitLoss" xlink:type="arc" weight="-1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProvisionForDoubtfulAccounts" xlink:label="loc_us-gaapProvisionForDoubtfulAccounts" />
    <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapProvisionForDoubtfulAccounts" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DepreciationDepletionAndAmortization" xlink:label="loc_us-gaapDepreciationDepletionAndAmortization" />
    <link:calculationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapDepreciationDepletionAndAmortization" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit" xlink:label="loc_us-gaapDeferredIncomeTaxExpenseBenefit" />
    <link:calculationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapDeferredIncomeTaxExpenseBenefit" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensation" xlink:label="loc_us-gaapShareBasedCompensation" />
    <link:calculationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapShareBasedCompensation" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable" xlink:label="loc_us-gaapIncreaseDecreaseInAccountsReceivable" />
    <link:calculationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapIncreaseDecreaseInAccountsReceivable" xlink:type="arc" weight="-1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets" xlink:label="loc_us-gaapIncreaseDecreaseInOtherOperatingAssets" />
    <link:calculationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapIncreaseDecreaseInOtherOperatingAssets" xlink:type="arc" weight="-1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInAccountsPayable" xlink:label="loc_us-gaapIncreaseDecreaseInAccountsPayable" />
    <link:calculationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapIncreaseDecreaseInAccountsPayable" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInDeferredRevenue" xlink:label="loc_us-gaapIncreaseDecreaseInDeferredRevenue" />
    <link:calculationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapIncreaseDecreaseInDeferredRevenue" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities" xlink:label="loc_us-gaapIncreaseDecreaseInAccruedLiabilities" />
    <link:calculationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapIncreaseDecreaseInAccruedLiabilities" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:label="loc_us-gaapNetCashProvidedByUsedInInvestingActivities" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment" xlink:label="loc_us-gaapPaymentsToAcquirePropertyPlantAndEquipment" />
    <link:calculationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInInvestingActivities" xlink:to="loc_us-gaapPaymentsToAcquirePropertyPlantAndEquipment" xlink:type="arc" weight="-1" />
    <link:loc xlink:type="locator" xlink:href="isdr-20221231.xsd#isdr_PurchaseOfAcquiredBusinessNetOfCashReceived" xlink:label="loc_isdrPurchaseOfAcquiredBusinessNetOfCashReceived" />
    <link:calculationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInInvestingActivities" xlink:to="loc_isdrPurchaseOfAcquiredBusinessNetOfCashReceived" xlink:type="arc" weight="-1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquireSoftware" xlink:label="loc_us-gaapPaymentsToAcquireSoftware" />
    <link:calculationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInInvestingActivities" xlink:to="loc_us-gaapPaymentsToAcquireSoftware" xlink:type="arc" weight="-1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:label="loc_us-gaapNetCashProvidedByUsedInFinancingActivities" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock" xlink:label="loc_us-gaapPaymentsForRepurchaseOfCommonStock" />
    <link:calculationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInFinancingActivities" xlink:to="loc_us-gaapPaymentsForRepurchaseOfCommonStock" xlink:type="arc" weight="-1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromStockOptionsExercised" xlink:label="loc_us-gaapProceedsFromStockOptionsExercised" />
    <link:calculationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInFinancingActivities" xlink:to="loc_us-gaapProceedsFromStockOptionsExercised" xlink:type="arc" weight="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect" xlink:label="loc_us-gaapCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect" />
    <link:calculationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect" xlink:to="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:type="arc" weight="1" />
    <link:calculationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect" xlink:to="loc_us-gaapNetCashProvidedByUsedInInvestingActivities" xlink:type="arc" weight="1" />
    <link:calculationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect" xlink:to="loc_us-gaapNetCashProvidedByUsedInFinancingActivities" xlink:type="arc" weight="1" />
  </link:calculationLink>
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/DescriptionBackgroundAndBasisOfOperations" xlink:title="000008 - Disclosure - Description, Background and Basis of Operations" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/SummaryOfSignificantAccountingPolicies" xlink:title="000009 - Disclosure - Summary of Significant Accounting Policies" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/FixedAssets" xlink:title="000010 - Disclosure - Fixed Assets" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/AcquisitionOfInewswireComLlc" xlink:title="000011 - Disclosure - Acquisition of iNewswire.com LLC" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/GoodwillAndOtherIntangibleAssets" xlink:title="000012 - Disclosure - Goodwill and Other Intangible Assets" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/LineOfCredit" xlink:title="000013 - Disclosure - Line of Credit" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/Equity" xlink:title="000014 - Disclosure - Equity" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/StockOptionsAndRestrictedStockUnits" xlink:title="000015 - Disclosure - Stock Options and Restricted Stock Units" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/Leases" xlink:title="000016 - Disclosure - Leases" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/CommitmentsAndContingencies" xlink:title="000017 - Disclosure - Commitments and Contingencies" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/Revenues" xlink:title="000018 - Disclosure - Revenues" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/IncomeTaxes" xlink:title="000019 - Disclosure - Income Taxes" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/EmployeeBenefitPlans" xlink:title="000020 - Disclosure - Employee Benefit Plans" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/SummaryOfSignificantAccountingPoliciesPolicies" xlink:title="000021 - Disclosure - Summary of Significant Accounting Policies (Policies)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/SummaryOfSignificantAccountingPoliciesTables" xlink:title="000022 - Disclosure - Summary of Significant Accounting Policies (Tables)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/FixedAssetsTables" xlink:title="000023 - Disclosure - Fixed Assets (Tables)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/AcquisitionOfInewswireComLlcTables" xlink:title="000024 - Disclosure - Acquisition of iNewswire.com LLC (Tables)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/GoodwillAndOtherIntangibleAssetsTables" xlink:title="000025 - Disclosure - Goodwill and Other Intangible Assets (Tables)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/EquityTables" xlink:title="000026 - Disclosure - Equity (Tables)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/StockOptionsAndRestrictedStockUnitsTables" xlink:title="000027 - Disclosure - Stock Options and Restricted Stock Units (Tables)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/LeasesTables" xlink:title="000028 - Disclosure - Leases (Tables)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/RevenueTables" xlink:title="000029 - Disclosure - Revenue (Tables)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/IncomeTaxesTables" xlink:title="000030 - Disclosure - Income Taxes (Tables)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/SummaryOfSignificantAccountingPoliciesDetails" xlink:title="000031 - Disclosure - Summary of Significant Accounting Policies (Details)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/SummaryOfSignificantAccountingPoliciesDetails1" xlink:title="000032 - Disclosure - Summary of Significant Accounting Policies (Details 1)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/SummaryOfSignificantAccountingPoliciesDetails2" xlink:title="000033 - Disclosure - Summary of Significant Accounting Policies (Details 2)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/SummaryOfSignificantAccountingPoliciesDetailsNarrative" xlink:title="000034 - Disclosure - Summary of Significant Accounting Policies (Details Narrative)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/FixedAssetsDetails" xlink:title="000035 - Disclosure - Fixed Assets (Details)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/FixedAssetsDetailsNarrative" xlink:title="000036 - Disclosure - Fixed Assets (Details Narrative)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/AcquisitionOfInewswireComLlcDetails" xlink:title="000037 - Disclosure - Acquisition of iNewswire.com LLC (Details)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/AcquisitionOfInewswireComLlcDetails1" xlink:title="000038 - Disclosure - Acquisition of iNewswire.com LLC (Details 1)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/AcquisitionOfInewswireComLlcDetailsNarrative" xlink:title="000039 - Disclosure - Acquisition of iNewswire.com LLC (Details Narrative)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/GoodwillAndOtherIntangibleAssetsDetails" xlink:title="000040 - Disclosure - Goodwill and Other Intangible Assets (Details)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/GoodwillAndOtherIntangibleAssetsDetails1" xlink:title="000041 - Disclosure - Goodwill and Other Intangible Assets (Details 1)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/GoodwillAndOtherIntangibleAssetsDetailsNarrative" xlink:title="000042 - Disclosure - Goodwill and Other Intangible Assets (Details Narrative)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/LineOfCreditDetailsNarrative" xlink:title="000043 - Disclosure - Line of Credit (Details Narrative)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/EquityDetails" xlink:title="000044 - Disclosure - Equity (Details)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/EquityDetails1" xlink:title="000045 - Disclosure - Equity (Details 1)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/EquityDetailsNarrative" xlink:title="000046 - Disclosure - Equity (Details Narrative)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/StockOptionsAndRestrictedStockUnitsDetails" xlink:title="000047 - Disclosure - Stock Options and Restricted Stock Units (Details)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/StockOptionsAndRestrictedStockUnitsDetails1" xlink:title="000048 - Disclosure - Stock Options and Restricted Stock Units (Details 1)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/StockOptionsAndRestrictedStockUnitsDetails2" xlink:title="000049 - Disclosure - Stock Options and Restricted Stock Units (Details 2)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/StockOptionsAndRestrictedStockUnitsDetails3" xlink:title="000050 - Disclosure - Stock Options and Restricted Stock Units (Details 3)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/StockOptionsAndRestrictedStockUnitsDetails4" xlink:title="000051 - Disclosure - Stock Options and Restricted Stock Units (Details 4)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/StockOptionsAndRestrictedStockUnitsDetailsNarrative" xlink:title="000052 - Disclosure - Stock Options and Restricted Stock Units (Details Narrative)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/LeasesDetails" xlink:title="000053 - Disclosure - Leases (Details)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/LeasesDetails1" xlink:title="000054 - Disclosure - Leases (Details 1)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/LeasesDetailsNarrative" xlink:title="000055 - Disclosure - Leases (Details Narrative)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/RevenueDetails" xlink:title="000056 - Disclosure - Revenue (Details)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/IncomeTaxesDetails" xlink:title="000057 - Disclosure - Income Taxes (Details)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/IncomeTaxesDetails1" xlink:title="000058 - Disclosure - Income Taxes (Details 1)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/IncomeTaxesDetails2" xlink:title="000059 - Disclosure - Income Taxes (Details 2)" />
  <link:calculationLink xlink:type="extended" xlink:role="http://issuerdirect.com/role/EmployeeBenefitPlanDetailsNarrative" xlink:title="000060 - Disclosure - Employee Benefit Plan (Details Narrative)" />
</link:linkbase>
