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Commitments and Contingencies - License Agreement (Details)
1 Months Ended 12 Months Ended
May 31, 2012
USD ($)
Nov. 30, 2008
USD ($)
Dec. 31, 2020
USD ($)
item
Dec. 31, 2019
USD ($)
License Agreements        
Accrued license payments     $ 3,833 $ 506,000
License Agreement        
License Agreements        
Payments in in satisfaction of deferred annual fees     494,000  
License Agreement | Horizon Therapeutics, PLC        
License Agreements        
One-time non-refundable fee   $ 50,000    
Minimum annual commitment   $ 40,000    
Amended License Agreement        
License Agreements        
Deferrable minimum annual commitment $ 46,000      
Threshold amount of equity financing $ 2,000,000      
Accrued license payments     $ 3,833 $ 506,000
Amended License Agreement | Horizon Therapeutics, PLC        
License Agreements        
Number of milestones achieved | item     0  
Percentage of net sales used to calculate royalties payable     5.75%  
Percentage of reduction in royalties payable if third-party license is required     50.00%  
Percentage of sublicense income to be paid in addition to royalty payments     9.20%  
Period for advance notice of termination     90 days  
Term of license agreement     10 years  
Amended License Agreement | Horizon Therapeutics, PLC | Exercise of by-out option on or after commencement of first Phase II clinical trial        
License Agreements        
Buy-out option price     $ 500,000  
Amended License Agreement | Horizon Therapeutics, PLC | Exercise of by-out option prior to commencement of first Phase II clinical trial and prior to the commencement of the first Phase III clinical trial        
License Agreements        
Buy-out option price     1,000,000  
Amended License Agreement | Horizon Therapeutics, PLC | Exercise of by-out option prior to commencement of first Phase III clinical trial and prior to the filing of a NDA with the FDA        
License Agreements        
Buy-out option price     5,000,000  
Amended License Agreement | Horizon Therapeutics, PLC | Exercise of by-out option on or after the filing of a NDA for the first licensed product        
License Agreements        
Buy-out option price     8,000,000  
Amended License Agreement | Horizon Therapeutics, PLC | Commencement of Phase II        
License Agreements        
Amount of milestone payment     230,000  
Amended License Agreement | Horizon Therapeutics, PLC | Commencement of Phase III        
License Agreements        
Amount of milestone payment     575,000  
Amended License Agreement | Horizon Therapeutics, PLC | Filing of an NDA for Regulatory Approval (or equivalent in Europe or Japan)        
License Agreements        
Amount of milestone payment     1,150,000  
Amended License Agreement | Horizon Therapeutics, PLC | Receipt of Regulatory Approval in the United States        
License Agreements        
Amount of milestone payment     5,750,000  
Amended License Agreement | Horizon Therapeutics, PLC | Receipt of Regulatory Approval outside the United States        
License Agreements        
Amount of milestone payment     $ 5,750,000