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Stock-Based Compensation - Share-based compensation expense (Details) - USD ($) | 12 Months Ended
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Dec. 31, 2021 | Dec. 31, 2020
Stock-Based Compensation |  |
Stock-based compensation expense | $ 4,697,627 | $ 1,864,913
Research and development |  |
Stock-Based Compensation |  |
Stock-based compensation expense | 2,016,745 | 138,704
General and administrative |  |
Stock-Based Compensation |  |
Stock-based compensation expense | $ 2,680,882 | $ 1,726,209

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- Definition Amount of noncash expense for share-based payment arrangement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3602-108585 + Details
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