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Income Taxes - Reconciliation of income tax provision (benefit) (Details) - USD ($) | 12 Months Ended
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Dec. 31, 2021 | Dec. 31, 2020
Federal and state provision (benefit) for income taxes |  |
Federal provision (benefit) for income taxes | $ 0 | $ 0
State provision (benefit) for income taxes | $ 0 | $ 0
Reconciliation of income tax benefit computed at the statutory federal income tax rate to income taxes as reflected in the financial statements |  |
Federal income tax benefits at statutory rate | 21.00% | 21.00%
State and local tax, net of federal benefit | 13.70% | 7.60%
Permanent differences | 0.10% | (0.80%)
Research and development credit | 2.40% | 1.90%
Stock-based compensation | 15.70% |
Change in valuation allowance | (52.90%) | (29.70%)
Effective income tax rate | 0.00% | 0.00%

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