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Income Taxes - Reconciliation of income tax provision (benefit) (Details) - USD ($)
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Federal and state provision (benefit) for income taxes    
Federal provision (benefit) for income taxes $ 0 $ 0
State provision (benefit) for income taxes $ 0 $ 0
Reconciliation of income tax benefit computed at the statutory federal income tax rate to income taxes as reflected in the financial statements    
Federal income tax benefits at statutory rate 21.00% 21.00%
State and local tax, net of federal benefit 13.70% 7.60%
Permanent differences 0.10% (0.80%)
Research and development credit 2.40% 1.90%
Stock-based compensation 15.70%  
Change in valuation allowance (52.90%) (29.70%)
Effective income tax rate 0.00% 0.00%