<SEC-DOCUMENT>0001104659-22-005057.txt : 20220118
<SEC-HEADER>0001104659-22-005057.hdr.sgml : 20220118
<ACCEPTANCE-DATETIME>20220118210746
ACCESSION NUMBER:		0001104659-22-005057
CONFORMED SUBMISSION TYPE:	5
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20211231
FILED AS OF DATE:		20220118
DATE AS OF CHANGE:		20220118

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Maccecchini Maria-Luisa
		CENTRAL INDEX KEY:			0001315018

	FILING VALUES:
		FORM TYPE:		5
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-39202
		FILM NUMBER:		22536604

	MAIL ADDRESS:	
		STREET 1:		1223 FOXGLOVE LANE
		CITY:			WEST CHESTER
		STATE:			PA
		ZIP:			19380

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Annovis Bio, Inc.
		CENTRAL INDEX KEY:			0001477845
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				262540421
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		1055 WESTLAKES DRIVE, SUITE 300
		CITY:			BERWYN
		STATE:			PA
		ZIP:			19312
		BUSINESS PHONE:		610-727-3913

	MAIL ADDRESS:	
		STREET 1:		1055 WESTLAKES DRIVE, SUITE 300
		CITY:			BERWYN
		STATE:			PA
		ZIP:			19312

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	QR Pharma, Inc.
		DATE OF NAME CHANGE:	20091202
</SEC-HEADER>
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<TYPE>5
<SEQUENCE>1
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<DESCRIPTION>OWNERSHIP DOCUMENT
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        <issuerName>Annovis Bio, Inc.</issuerName>
        <issuerTradingSymbol>ANVS</issuerTradingSymbol>
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        <reportingOwnerId>
            <rptOwnerCik>0001315018</rptOwnerCik>
            <rptOwnerName>Maccecchini Maria-Luisa</rptOwnerName>
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            <rptOwnerStreet1>C/O ANNOVIS BIO, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>1055 WESTLAKES DRIVE, SUITE 300</rptOwnerStreet2>
            <rptOwnerCity>BERWYN</rptOwnerCity>
            <rptOwnerState>PA</rptOwnerState>
            <rptOwnerZipCode>19312</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
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            <isDirector>1</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>President and CEO</officerTitle>
            <otherText></otherText>
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    <footnotes>
        <footnote id="F1">Charitable gift that was not previously reported in a Form 5 for the fiscal year ended December 31, 2020.</footnote>
        <footnote id="F2">Charitable gift.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Jeffrey McGroarty, Attorney-in-Fact for Maria L. Maccecchini</signatureName>
        <signatureDate>2022-01-18</signatureDate>
    </ownerSignature>
</ownershipDocument>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
