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Income Taxes - Reconciliation of income tax provision (benefit) (Details) - USD ($)	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Federal and state provision (benefit) for income taxes
Federal provision (benefit) for income taxes	$ 0	$ 0
State provision (benefit) for income taxes	$ 0	$ 0
Reconciliation of income tax benefit computed at the statutory federal income tax rate to income taxes
Federal income tax benefits at statutory rate	21.00%	21.00%
State and local tax, net of federal benefit	5.70%	13.70%
Permanent differences	(1.50%)	0.10%
Research and development credit	3.80%	2.40%
Stock-based compensation	0.80%	15.70%
Change in valuation allowance	(29.80%)	(52.90%)
Effective income tax rate	0.00%	0.00%

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- Definition

Percentage of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations.

+ References

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Percentage of domestic federal statutory tax rate applicable to pretax income (loss).

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Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to changes in the valuation allowance for deferred tax assets.

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Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to nondeductible expenses.

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Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to research and development expense.

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Amount of current and deferred federal tax expense (benefit) attributable to income (loss) from continuing operations. Includes, but is not limited to, current and deferred national tax expense (benefit) for non-US (United States of America) jurisdiction.

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Amount of current and deferred state and local tax expense (benefit) attributable to income (loss) from continuing operations. Includes, but is not limited to, current and deferred regional, territorial, and provincial tax expense (benefit) for non-US (United States of America) jurisdiction.

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