<SEC-DOCUMENT>0001104659-25-042679.txt : 20250430
<SEC-HEADER>0001104659-25-042679.hdr.sgml : 20250430
<ACCEPTANCE-DATETIME>20250430172039
ACCESSION NUMBER:		0001104659-25-042679
CONFORMED SUBMISSION TYPE:	DEF 14A
PUBLIC DOCUMENT COUNT:		4
CONFORMED PERIOD OF REPORT:	20250617
FILED AS OF DATE:		20250430
DATE AS OF CHANGE:		20250430

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Annovis Bio, Inc.
		CENTRAL INDEX KEY:			0001477845
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				262540421
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		DEF 14A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-39202
		FILM NUMBER:		25897552

	BUSINESS ADDRESS:	
		STREET 1:		101 LINDENWOOD DRIVE, SUITE 225
		CITY:			MALVERN
		STATE:			PA
		ZIP:			19355
		BUSINESS PHONE:		484-875-3192

	MAIL ADDRESS:	
		STREET 1:		101 LINDENWOOD DRIVE, SUITE 225
		CITY:			MALVERN
		STATE:			PA
		ZIP:			19355

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	QR Pharma, Inc.
		DATE OF NAME CHANGE:	20091202
</SEC-HEADER>
<DOCUMENT>
<TYPE>DEF 14A
<SEQUENCE>1
<FILENAME>tm252538d1_def14a.htm
<DESCRIPTION>DEF 14A
<TEXT>
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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0"></p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</p>

<p style="font: 14pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>UNITED STATES<br>
SECURITIES AND EXCHANGE COMMISSION</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>Washington, D.C. 20549</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>SCHEDULE 14A</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>Proxy Statement Pursuant to Section&nbsp;14(a)&nbsp;of<br>
the Securities Exchange Act of 1934</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Filed by the Registrant&#8239;&#8239;<font style="font-family: Wingdings">&#120;</font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Filed
by a Party other than the Registrant&#8239;&#8239;</font><font style="font-family: Wingdings"><font style="font-family: Wingdings">&#168;</font></font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Check the appropriate box:</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

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    <td style="font-size: 10pt; text-align: justify"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Preliminary Proxy Statement</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

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    <td style="width: 0.25in; font-size: 10pt"><font style="font-family: Wingdings; font-size: 10pt"><font style="font-family: Wingdings">&#168;</font></font></td>
    <td style="font-size: 10pt; text-align: justify"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Confidential, for Use of the Commission Only (as permitted by Rule&nbsp;14a-6(e)(2))</b></font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

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    <td style="width: 0.25in; font-size: 10pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><font style="font-family: Wingdings">&#120;</font></font></td>
    <td style="font-size: 10pt; text-align: justify"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Definitive Proxy Statement</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

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    <td style="width: 0.25in; font-size: 10pt"><font style="font-family: Wingdings; font-size: 10pt"><font style="font-family: Wingdings">&#168;</font></font></td>
    <td style="font-size: 10pt; text-align: justify"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Definitive Additional Materials</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

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  <tr style="vertical-align: top">
    <td style="width: 0.25in; font-size: 10pt"><font style="font-family: Wingdings; font-size: 10pt"><font style="font-family: Wingdings">&#168;</font></font></td>
    <td style="font-size: 10pt; text-align: justify"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Soliciting Material under &sect;240.14a-12</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</p>

<p style="border-bottom: Black 0.5pt solid; font: 14pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>Annovis Bio,&nbsp;Inc.</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0pt; margin-bottom: 0pt">(Name of Registrant as Specified in Its Charter)</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="border-top: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Name of Person(s)&nbsp;Filing Proxy Statement,
if other than the Registrant)</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Payment of Filing Fee (Check all boxes that apply):</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

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    <td style="width: 0.25in; font-size: 10pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><font style="font-family: Wingdings">&#120;</font></font></td>
    <td style="font-size: 10pt; text-align: justify"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">No fee required.</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

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    <td style="width: 0.25in; font-size: 10pt"><font style="font-family: Wingdings; font-size: 10pt"><font style="font-family: Wingdings">&#168;</font></font></td>
    <td style="font-size: 10pt; text-align: justify"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Fee paid previously with preliminary materials.</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
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    <td style="width: 0.25in; font-size: 10pt"><font style="font-family: Wingdings; font-size: 10pt"><font style="font-family: Wingdings">&#168;</font></font></td>
    <td style="font-size: 10pt; text-align: justify"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Fee computed on table in exhibit required by Item 25(b)&nbsp;per Exchange Act Rules&nbsp;14a6(i)(1)&nbsp;and 0-11.</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0pt; margin-bottom: 0pt"><img src="tm252538d1_def14aimg001.jpg" alt=""></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>Annovis Bio,&nbsp;Inc.</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>101 Lindenwood Drive, Suite&nbsp;225<br>
Malvern, PA 19355</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">April&nbsp;30, 2025</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">To our Stockholders:</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">You are cordially invited to attend our 2025 Annual
Meeting of Stockholders on Tuesday, June&nbsp;17, 2025, at 10:00 a.m., Eastern Time (the &ldquo;Annual Meeting&rdquo;) to be held as a
virtual meeting at https://web.viewproxy.com/AnnovisBio/2025.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">If you attend the Annual Meeting, you will be able
to vote and submit questions during the meeting by using the Virtual Control Number we have provided to you with the Notice of Internet
Availability of Proxy Materials. We are pleased to furnish proxy materials to stockholders primarily over the Internet. We will commence
mailing to our stockholders on or about May&nbsp;2, 2025, a Notice of Internet Availability of Proxy Materials containing instructions
on how to access the electronic copies of our 2025 Proxy Statement and our Annual Report on Form&nbsp;10-K for the year ended December&nbsp;31,
2024 (the &ldquo;Annual Report&rdquo;) and how to vote online. Internet distribution of our proxy materials expedites receipt by stockholders,
lowers the cost of the Annual Meeting, and conserves natural resources. However, if you would prefer to receive paper copies of our proxy
materials, please follow the instructions included in the Notice of Internet Availability of Proxy Materials. If you choose to receive
your Annual Meeting materials by mail, the notice of the Annual Meeting, Proxy Statement, the Annual Report and proxy card from our Board
of Directors will be enclosed.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Please refer to the Proxy Statement for detailed
information on each of the proposals and the Annual Meeting. Your vote is important, and we strongly urge all stockholders to vote their
shares. For most items, including the election of directors, your shares will not be voted unless you provide voting instructions via
the Internet or by returning a proxy card or voting instruction card. We encourage you to vote promptly, even if you plan to attend the
Annual Meeting.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <tr style="vertical-align: bottom">
    <td style="width: 50%">&nbsp;</td>
    <td style="width: 50%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Best regards,</font></td></tr>
  <tr style="vertical-align: bottom">
    <td>&nbsp;</td>
    <td>&nbsp;</td></tr>
  <tr style="vertical-align: bottom">
    <td>&nbsp;</td>
    <td style="border-bottom: black 1pt solid"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/ Maria Maccecchini</font></td></tr>
  <tr style="vertical-align: bottom">
    <td>&nbsp;</td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Maria Maccecchini,</font></td></tr>
  <tr style="vertical-align: bottom">
    <td>&nbsp;</td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">President and Chief Executive Officer</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in"></p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>Annovis Bio,&nbsp;Inc.</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>101 Lindenwood Drive, Suite&nbsp;225<br>
Malvern, PA 19355</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>NOTICE OF ANNUAL MEETING OF STOCKHOLDERS</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>To Be Held June&nbsp;17, 2025</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">To our Stockholders:</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">NOTICE IS HEREBY GIVEN that you are invited to attend the 2025 Annual
Meeting of Stockholders (the &ldquo;Annual Meeting&rdquo;) of Annovis Bio,&nbsp;Inc. on Tuesday, June&nbsp;17, 2025, at 10:00 a.m., ET.
This year&rsquo;s Annual Meeting will be held virtually at https://web.viewproxy.com/AnnovisBio/2025.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">At the Annual Meeting, shareholders will vote:</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
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    <td style="width: 0.5in">&nbsp;</td>
    <td style="width: 0.5in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">1.</font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">To elect the five director nominees named in the accompanying Proxy Statement;</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 0.5in">&nbsp;</td>
    <td style="width: 0.5in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">2.</font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">To ratify the selection of <font style="background-color: white">Ernst&nbsp;&amp; Young LLP </font>as our independent registered public accounting firm for the fiscal year ending December&nbsp;31, 2025; and</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 0.5in">&nbsp;</td>
    <td style="width: 0.5in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">3.</font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">To transact such other business as may properly be brought before the Annual Meeting or any adjournment or postponement thereof.</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; text-align: left; margin: 0pt 0; text-indent: 0.5in">Our Board of Directors unanimously recommends that
you vote &ldquo;FOR&rdquo; the election of all of the director nominees (Proposal 1) and &ldquo;FOR&rdquo; the proposal to ratify <font style="background-color: white">Ernst&nbsp;&amp;
Young LLP </font>as our independent registered public accounting firm for the fiscal year ending December&nbsp;31, 2025 (Proposal 2).</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; text-align: left; margin: 0pt 0; text-indent: 0.5in">The Board of Directors has fixed April&nbsp;28,
2025, at the close of business, as the record date for the determination of stockholders entitled to notice of, and to vote at, the Annual
Meeting.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">In accordance with Securities and Exchange Commission
rules, we are furnishing these proxy materials and our 2024 Annual Report on Form&nbsp;10-K via the Internet. On or about May&nbsp;2,
2025, we mailed to stockholders as of the record date a notice with instructions on how to access our Annual Meeting materials and how
to vote via the Internet, by mail or telephone.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <tr style="vertical-align: bottom">
    <td style="width: 50%">&nbsp;</td>
    <td style="width: 50%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">By Order of the Board of Directors,</font></td></tr>
  <tr style="vertical-align: bottom">
    <td>&nbsp;</td>
    <td>&nbsp;</td></tr>
  <tr style="vertical-align: bottom">
    <td>&nbsp;</td>
    <td style="border-bottom: black 1pt solid"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/ Maria Maccecchini</font></td></tr>
  <tr style="vertical-align: bottom">
    <td>&nbsp;</td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Maria Maccecchini,</font></td></tr>
  <tr style="vertical-align: bottom">
    <td>&nbsp;</td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">President and Chief Executive Officer</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Malvern, Pennsylvania</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">April&nbsp;30, 2025</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>YOUR VOTE IS IMPORTANT</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><i>If your shares are held in a brokerage account
or by another nominee record holder, please be sure to mark your voting choices on the voting instruction card that accompanies this Proxy
Statement. <u>If you fail to specify your voting instructions for the election of directors, your shares will not be voted in the election
of directors due to rules&nbsp;applicable to broker voting, or we may incur additional costs to solicit votes</u>.</i></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>TABLE OF CONTENTS</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

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  <tr>
    <td style="vertical-align: top; width: 94%">&nbsp;</td>
    <td style="border-bottom: black 1pt solid; vertical-align: bottom; width: 6%; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Page</b></font></td></tr>
  <tr>
    <td style="vertical-align: top"><a href="#a_001"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>PROXY STATEMENT</b></font></a></td>
    <td style="vertical-align: bottom; text-align: right"><a href="#a_001"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>1</b></font></a></td></tr>
  <tr style="background-color: white">
    <td style="vertical-align: top"><a href="#a_002"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>QUESTIONS AND ANSWERS ABOUT THE PROXY MATERIALS AND OUR ANNUAL MEETING</b></font></a></td>
    <td style="vertical-align: bottom; text-align: right"><a href="#a_002"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>1</b></font></a></td></tr>
  <tr>
    <td style="vertical-align: top"><a href="#a_003"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>BOARD OF DIRECTORS</b></font></a></td>
    <td style="vertical-align: bottom; text-align: right"><a href="#a_003"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>6</b></font></a></td></tr>
  <tr style="background-color: white">
    <td style="vertical-align: top"><a href="#a_004"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>AUDIT COMMITTEE REPORT</b></font></a></td>
    <td style="vertical-align: bottom; text-align: right"><a href="#a_004"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>13</b></font></a></td></tr>
  <tr>
    <td style="vertical-align: top"><a href="#a_005"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS, DIRECTORS AND OFFICERS</b></font></a></td>
    <td style="vertical-align: bottom; text-align: right"><a href="#a_005"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>14</b></font></a></td></tr>
  <tr style="background-color: white">
    <td style="vertical-align: top"><a href="#a_006"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>EXECUTIVE OFFICERS</b></font></a></td>
    <td style="vertical-align: bottom; text-align: right"><a href="#a_006"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>15</b></font></a></td></tr>
  <tr>
    <td style="vertical-align: top"><a href="#a_007"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>EXECUTIVE AND DIRECTOR COMPENSATION</b></font></a></td>
    <td style="vertical-align: bottom; text-align: right"><a href="#a_007"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>15</b></font></a></td></tr>
  <tr style="background-color: white">
    <td style="vertical-align: top"><a href="#a_008"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>CERTAIN RELATIONSHIPS AND RELATED PARTY TRANSACTIONS</b></font></a></td>
    <td style="vertical-align: bottom; text-align: right"><a href="#a_008"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>18</b></font></a></td></tr>
  <tr>
    <td style="vertical-align: top"><a href="#a_009"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>PROPOSAL 1: ELECTION OF DIRECTORS</b></font></a></td>
    <td style="vertical-align: bottom; text-align: right"><a href="#a_009"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>18</b></font></a></td></tr>
  <tr>
    <td style="vertical-align: top"><a href="#a_010"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>PROPOSAL 2: RATIFICATION OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM</b></font></a></td>
    <td style="vertical-align: bottom; text-align: right"><a href="#a_010"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>18</b></font></a></td></tr>
  <tr style="background-color: white">
    <td style="vertical-align: top"><a href="#a_012"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>STOCKHOLDER PROPOSALS AND DIRECTOR NOMINATIONS FOR 2026 ANNUAL MEETING OF STOCKHOLDERS</b></font></a></td>
    <td style="vertical-align: bottom; text-align: right"><a href="#a_012"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>20</b></font></a></td></tr>
  <tr>
    <td style="vertical-align: top"><a href="#a_013"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>ANNUAL REPORT</b></font></a></td>
    <td style="vertical-align: bottom; text-align: right"><a href="#a_013"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>20</b></font></a></td></tr>
  <tr style="background-color: white">
    <td style="vertical-align: top"><a href="#a_014"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>DELIVERY OF DOCUMENTS TO STOCKHOLDERS SHARING AN ADDRESS</b></font></a></td>
    <td style="vertical-align: bottom; text-align: right"><a href="#a_014"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>20</b></font></a></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>Annovis Bio,&nbsp;Inc.</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>101 Lindenwood Drive, Suite&nbsp;225<br>
Malvern, Pennsylvania 19355</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b><a name="a_001"></a>PROXY STATEMENT</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>ANNUAL MEETING OF STOCKHOLDERS<br>
To Be Held June&nbsp;17, 2025</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>IMPORTANT NOTICE REGARDING THE INTERNET AVAILABILITY OF PROXY MATERIALS
FOR THE ANNUAL STOCKHOLDER MEETING TO BE HELD ON TUESDAY, JUNE 17, 2025</b>: Copies of this Proxy Statement and the accompanying form
of proxy card, and 2024 Annual Report on Form&nbsp;10-K (the &ldquo;Annual Report&rdquo;) are available at https://web.viewproxy.com/AnnovisBio/2025,
using your Virtual Control Number that was included in the Notice of Internet Availability of Proxy Materials you received in the mail.
If you want to receive a paper or e-mail copy of these documents, you must request one. There is no charge for requesting a copy. Please
choose one of the following methods to make your request:</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 48px; font-size: 10pt">&nbsp;</td>
    <td style="width: 48px; font-size: 10pt"><font style="font-size: 10pt">1)</font></td>
    <td style="font-size: 10pt"><font style="font-size: 10pt">BY INTERNET: https://web.viewproxy.com/AnnovisBio/2025</font></td></tr>
  </table>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 0.5in">&nbsp;</td>
    <td style="width: 0.5in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">2)</font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">BY TELEPHONE: 1-866-804-9616 </font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 0.5in">&nbsp;</td>
    <td style="width: 0.5in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">3)</font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">BY MAIL: Mark, sign and date your Proxy Card and fold and return your Proxy Card in the Prepaid Envelope provided</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">* If requesting materials by e-mail, please send
a blank e-mail with your Virtual Control Number that was included in the Notice of Internet Availability of Proxy Materials.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">This Proxy Statement and the accompanying proxy card, the foregoing
Notice of Internet Availability of Proxy Materials and the Annual Report are intended to be sent or given to stockholders of Annovis Bio,&nbsp;Inc.
(the &ldquo;Company,&rdquo; &ldquo;Annovis,&rdquo; &ldquo;we,&rdquo; &ldquo;us&rdquo; or &ldquo;our&rdquo;) on or about May&nbsp;2, 2025,
in connection with the solicitation of proxies on behalf of our Board of Directors (the &ldquo;Board&rdquo;) for use at our 2025 Annual
Meeting of Stockholders (the &ldquo;Annual Meeting&rdquo;), to be held on Tuesday, June&nbsp;17, 2025, at 10:00 a.m., Eastern Time (ET),
virtually at https://web.viewproxy.com/AnnovisBio/2025, and at any adjournment or postponement thereof.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b><a name="a_002"></a>QUESTIONS AND ANSWERS ABOUT THE PROXY MATERIALS
AND OUR ANNUAL MEETING</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Q: Why am I receiving these materials?</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>A:
</b></font>You have received these proxy materials because the Board is soliciting your proxy to vote your shares at the Annual Meeting.
This Proxy Statement includes information that we are required to provide to you under Securities and Exchange Commission (&ldquo;SEC&rdquo;)
rules&nbsp;and is designed to assist you in voting your shares.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Pursuant to the &ldquo;notice and access&rdquo; rules&nbsp;adopted
by the SEC, we have elected to provide stockholders access to our proxy materials over the Internet. Accordingly, we sent the Notice of
Internet Availability of Proxy Materials to all of our stockholders as of the close of business on April&nbsp;28, 2025 (the &ldquo;Record
Date&rdquo;). The Notice of Internet Availability of Proxy Materials includes instructions on how to access our proxy materials over the
internet and how to request a printed copy of these materials. In addition, by following the instructions in the Notice of Internet Availability
of Proxy Materials, stockholders may request to receive proxy materials in printed form by mail or electronically by e-mail on an ongoing
basis.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Q: What is included in these materials?</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>A:
</b></font>These materials include:</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

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  <tr style="vertical-align: bottom">
    <td style="width: 0.25in">&nbsp;</td>
    <td style="width: 0.25in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b><font style="font-family: Symbol">&middot;</font></b></font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">this Proxy Statement for the Annual Meeting; </font></td></tr>
  <tr style="vertical-align: bottom">
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td></tr>
  <tr style="vertical-align: bottom">
    <td>&nbsp;</td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT></b></font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">a proxy card for the Annual Meeting; and</font></td></tr>
</table>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</p>

<p style="margin: 0"></p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</p>

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  <tr style="vertical-align: bottom">
    <td style="width: 0.25in">&nbsp;</td>
    <td style="width: 0.25in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT>&nbsp;</b></font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">the Annual Report on Form&nbsp;10-K.</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Q: Who is entitled to vote?</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; text-align: left; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>A:</b></font>
Only stockholders of record as of the Record Date shall be entitled to notice of, and to vote at, the Annual Meeting. During the ten days
before the Annual Meeting, you may inspect a list of stockholders eligible to vote. If you would like to inspect the list, please call
our Secretary at 484-875-3192 to arrange a visit to our offices. The list will also be available on request during the Annual Meeting.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Q: How many shares of common stock can vote?</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; text-align: left; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>A:</b></font>
There were 19,486,231 shares of common stock outstanding as of the Record Date. Each stockholder entitled to vote at the Annual Meeting
may cast one vote for each share of common stock owned by such stockholder that has voting power upon each matter considered at the Annual
Meeting. Our stockholders do not have the right to cumulate their votes in elections of directors.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Q: What may I vote on?</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>A:</b></font>
You may vote on the following matters:</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 0.5in">&nbsp;</td>
    <td style="width: 0.5in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">1.</font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">the election of five directors who have been nominated to serve on our Board;</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 0.5in">&nbsp;</td>
    <td style="width: 0.5in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">2.</font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">the ratification of the selection of <font style="background-color: white">Ernst&nbsp;&amp; Young LLP </font>as our independent registered public accounting firm for the year ending December&nbsp;31, 2025; and</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 0.5in">&nbsp;</td>
    <td style="width: 0.5in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">3.</font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">any other business that may properly come before the Annual Meeting and any adjournment or postponement thereof.</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Q: Will any other business be presented for action by stockholders
at the Annual Meeting?</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>A:</b></font>
Management knows of no business that will be presented at the Annual Meeting other than Proposals 1 and 2. If any other matter properly
comes before the Annual Meeting, the persons named as proxies in the accompanying proxy card intend to vote the proxies (which confer
discretionary authority to vote on such matters) in accordance with their judgment on the matter.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Q: How does the Board recommend that I vote on each of the proposals?</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>A:</b></font>
The Board recommends a vote &ldquo;FOR&rdquo; each of the director nominees and &ldquo;FOR&rdquo; the ratification of <font style="background-color: white">Ernst&nbsp;&amp;
Young LLP </font>as our independent registered public accounting firm for the year ending December&nbsp;31, 2025.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Q: How do I vote my shares?</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>A:
</b></font>The answer depends on whether you own your shares of common stock of the Company directly (that is, you hold shares that show
your name as the registered stockholder) or if your shares are held in a brokerage account or by another nominee holder.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><i>If
you own shares of the Company directly (i.e., you are a &ldquo;registered stockholder&rdquo;)</i></font>: your proxy is being solicited
directly by us, and you can vote by Internet, by telephone, by mail or you can vote at our Annual Meeting. You are encouraged to vote
prior to the Annual Meeting to ensure that your shares will be represented.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"></Font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i>If you wish to vote by Internet,</i> go to https://web.viewproxy.com/AnnovisBio/2025
and log in using your Virtual Control Number that was included in the Notice of Internet Availability of Proxy Materials.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><i>If
you wish to vote by telephone, </i></font>call 1-866-804-9616. Use any touch-tone telephone to vote your shares using your Virtual Control
Number that was included in the Notice of Internet Availability of Proxy Materials.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><i>If
you wish to vote by mail</i></font>, please request a paper or e-mail copy of the materials, which will include a proxy card. You can
request a paper or e-mail copy of the materials at no charge to you through one of the following methods:</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: -0.5in">1) BY INTERNET: https://web.viewproxy.com/AnnovisBio/2025</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: -0.5in">2) BY TELEPHONE: 1-866-804-9616</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: -0.5in">3) BY MAIL: Mark, sign and date your Proxy
Card and fold and return your Proxy Card in the Prepaid Envelope provided</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">* If requesting materials by e-mail, please send
a blank e-mail with your Virtual Control Number that was included in the Notice of Internet Availability of Proxy Materials.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; text-align: left; margin: 0pt 0">If you sign your proxy card but do not indicate how you wish to vote,
the proxies will vote your shares &ldquo;FOR&rdquo; each of the five director nominees and &ldquo;FOR&rdquo; the ratification of <font style="background-color: white">Ernst&nbsp;&amp;
Young LLP </font>as our independent registered public accounting firm, and, in their discretion, on any other matter that properly comes
before the Annual Meeting. Unsigned proxy cards will not be counted.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><i>If
you wish to vote at the Annual Meeting</i></font>, you will be able to vote your shares if you register to attend, and attend (virtually),
the Annual Meeting pursuant to the instructions below.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><i>If
you hold your shares of the Company through a broker, bank or other nominee</i></font>: a voting instruction card has been provided to
you by your broker, bank or other nominee describing how to vote your shares. If you receive a voting instruction card, you can vote by
completing and returning the voting instruction card. <i>Please be sure to mark your voting choices on your voting instruction card before
you return it</i>. You may also be able to vote by telephone, via the Internet, or at the Annual Meeting, depending upon your voting instructions.
Please refer to the instructions provided with your voting instruction card and see &ldquo;What do I need to do to attend the Annual Meeting
virtually?&rdquo; below for information about voting in these ways. See also &ldquo;What is the effect if I fail to give voting instructions
to my broker or other nominee?&rdquo; below.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Q: What do I need to do to attend the Annual Meeting virtually?</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"></Font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>A: </b>In order to attend our 2025 Annual Meeting live via the Internet,
you must register at <u>https://web.viewproxy.com/AnnovisBio/2025</u> by 11:59 p.m.&nbsp;ET on June&nbsp;14, 2025, using your Virtual
Control Number that was included in the Notice of Internet Availability of Proxy Materials or your proxy card (if you received a printed
copy of the proxy materials). If you hold your shares beneficially through a bank or broker, you must provide a legal proxy from your
bank or broker during registration and you will be assigned a Virtual Control Number in order to vote your shares during the Annual Meeting.
If you are unable to obtain a legal proxy to vote your shares, you will still be able to attend the Annual Meeting (but will not be able
to vote your shares) so long as you demonstrate proof of stock ownership. Instructions on how to connect and participate via the Internet,
including how to demonstrate proof of stock ownership, are posted at www.viewproxy.com/AnnovisBio/2025.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">On the day of the Annual Meeting, if you have properly registered,
you may enter the Annual Meeting at <u>https://web.viewproxy.com/AnnovisBio/2025</u> by logging in using the password you received via
e-mail in your registration confirmation. You are entitled to attend our Annual Meeting only if you were a stockholder as of the Record
Date.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Q: Will I have the same participation rights in this virtual-only
stockholder meeting as I would have at an in-person stockholder meeting?</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>A:</b></font>
Yes. If you register to attend, and attend, the Annual Meeting pursuant to the instructions above, you will be able to vote online during
the Annual Meeting, change a vote you may have submitted previously, or ask questions online that will be reviewed and answered by the
speakers. We have created and implemented the virtual format to facilitate stockholder attendance and participation by enabling stockholders
to participate fully from any location, at no cost. You will, however, bear any costs associated with your Internet access, such as usage
charges from Internet access providers and telephone companies. A virtual Annual Meeting makes it possible for more stockholders, regardless
of size, resources or physical location, to have direct access to information more quickly, while saving the Company and our stockholders
time and money. We also believe that the online tools we have selected will increase stockholder communication. Both stockholders of record
and street name stockholders will be able to attend the Annual Meeting via live audio webcast, submit their questions during the meeting
and vote their shares electronically at the Annual Meeting.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"></Font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i>Technical Difficulties: </i>There will be technicians ready to assist
you with any technical difficulties accessing the Annual Meeting live audio webcast. Please be sure to check in by 9:45 a.m.&nbsp;ET on
June&nbsp;17, 2025 (15 minutes prior to the start of the meeting is recommended), so that any technical difficulties may be addressed
before the Annual Meeting live audio webcast begins. If you encounter any difficulties accessing the webcast during the check-in or meeting
time, please email VirtualMeeting@viewproxy.com or call 866-612-8937.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Q: What is a proxy?</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>A:
</b></font>A proxy is a person you appoint to vote on your behalf. By using any of the methods discussed above, you will be appointing
as your proxies Maria Maccecchini, Michael Hoffman, Claudine Bruck, Reid McCarthy and Mark White. They may act together or individually
on your behalf and will have the authority to appoint a substitute to act as proxy. Whether or not you expect to attend the Annual Meeting,
we request that you please use the means available to you to vote by proxy so as to ensure that your shares of common stock may be voted.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Q: What is the effect if I fail to give voting instructions to my
broker or other nominee?</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>A:</b></font>
If your shares are held by a broker or other nominee, you <i>must</i> provide your broker or nominee with instructions on how to vote
your shares for Proposal 1 in order for your shares to be counted. If you hold your shares in one of these ways, you are considered the
beneficial owner of shares held in street name, and these proxy materials are being forwarded to you by your broker, bank or other nominee
who is considered, with respect to those shares, the stockholder of record. As the beneficial owner, you have the right to direct your
broker, bank or other nominee on how to vote your shares. If you hold your shares in street name, your broker, bank or other nominee has
enclosed a voting instruction card for you to use in directing your broker, bank or other nominee in how to vote your shares. We encourage
you to provide voting instructions to your broker, bank or other nominee.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Brokers, banks or other nominees that are member firms of the New York
Stock Exchange (&ldquo;NYSE&rdquo;) and who hold shares in street name for customers have the discretion to vote those shares with respect
to certain matters if they have not received instructions from the beneficial owners. Brokers, banks or other nominees will have this
discretionary authority with respect to routine matters such as Proposal 2; however, they will not have this discretionary authority with
respect to non-routine matters, including Proposal 1. With respect to non-routine matters, if beneficial owners do not provide voting
instructions, these are called &ldquo;broker non-votes.&rdquo;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">In the event of a broker non-vote, such beneficial owners&rsquo; shares
will be included in determining whether a quorum is present, but otherwise will not be counted. In addition, abstentions will be included
in determining whether a quorum is present but otherwise will not be counted. Thus, a broker non-vote or an abstention will make a quorum
more readily obtainable, but a broker non-vote or an abstention will not otherwise affect the outcome of a vote on a proposal that requires
a plurality of the votes cast, and a broker non-vote will not otherwise affect the outcome of a vote on a proposal that requires a majority
of the votes cast. An abstention with respect to a proposal that requires the affirmative vote of a majority of the outstanding shares
will, however, have the same effect as a vote against the proposal. See &ldquo;What vote is required to approve each proposal?&rdquo;
below.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">We encourage you to provide voting instructions to the organization
that holds your shares.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Q: What if I want to change my vote or revoke my proxy?</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>A:</b></font>
A registered stockholder may change his or her vote or revoke his or her proxy at any time before the Annual Meeting by (i)&nbsp;going
to www.viewproxy.com/AnnovisBio/2025 and log in using your Virtual Control Number that was included in the Notice of Internet Availability
of Proxy Materials, (ii)&nbsp;attending and voting at the Annual Meeting, or (iii)&nbsp;submitting a later dated proxy card. We will count
your vote in accordance with the last instructions we receive from you prior to the closing of the polls, whether your instructions are
received by mail or at the Annual Meeting. If you hold your shares through a broker, bank or other nominee and wish to change your vote,
you must follow the procedures required by your nominee.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Q: What is a quorum?</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; text-align: left; margin-top: 0pt; margin-right: 0; margin-bottom: 0pt"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"></Font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>A:</b> The holders of one-third of the 19,486,231 shares of common
stock outstanding as of the Record Date, either present or represented by proxy, constitutes a quorum. A quorum is necessary in order
to conduct the Annual Meeting. If you choose to have your shares represented by proxy at the Annual Meeting, you will be considered part
of the quorum. Broker non-votes and abstentions will be counted as present for the purpose of establishing a quorum. If a quorum is not
present by attendance the Annual Meeting or represented by proxy, the stockholders present by attendance at the meeting or by proxy may
adjourn the Annual Meeting until a quorum is present. If an adjournment is for more than 30 days or a new record date is fixed for the
adjourned meeting, we will provide notice of the adjourned meeting to each stockholder of record entitled to vote at the meeting.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Q: What vote is required to approve each proposal?</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>A:
<i>Election of directors:</i></b></font> A plurality of the votes cast at the Annual Meeting is required for the election of directors.
This means that the five director nominees with the most votes for a particular director seat are elected to that seat. You may choose
to vote or withhold your vote for such nominees. A properly executed proxy marked &ldquo;WITHHOLD&rdquo; with respect to the election
of a director will not be voted with respect to the director indicated and will have no impact on the election of directors, although
it will be counted for the purposes of determining whether there is a quorum.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b><i>Ratification
of our independent registered public accounting firm:</i></b></font> A majority of the shares of stock that are present or represented
by proxy and entitled to vote at the Annual Meeting must be voted in favor of the proposal. A properly executed proxy marked &ldquo;ABSTAIN&rdquo;
with respect to the proposal will not be voted, although it will be counted for purposes of determining the number of shares of common
stock present or represented by proxy and entitled to vote. Accordingly, if you choose to &ldquo;ABSTAIN&rdquo; with respect to either
proposal, your abstention has the same effect as a vote &ldquo;AGAINST.&rdquo;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <tr style="vertical-align: bottom; background-color: white">
    <td style="border-bottom: black 1pt solid; width: 34%; padding-bottom: 1pt; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Proposal</b></font>&nbsp;</td>
    <td style="width: 1%; padding-bottom: 1pt; text-align: center">&nbsp;</td>
    <td style="border-bottom: black 1pt solid; width: 32%; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Vote Required</b></font></td>
    <td style="width: 1%; padding-bottom: 1pt; text-align: center">&nbsp;</td>
    <td style="border-bottom: black 1pt solid; text-align: center; width: 32%"><b>Broker&nbsp;Discretionary&nbsp;Voting</b> <b><br>
Allowed</b></td></tr>
  <tr>
    <td style="vertical-align: top"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">No.&nbsp;1 - Election of directors proposal</font></td>
    <td style="vertical-align: bottom">&nbsp;</td>
    <td style="vertical-align: top"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Plurality: Director nominees receiving the highest number of &ldquo;FOR&rdquo; votes</font></td>
    <td style="vertical-align: bottom">&nbsp;</td>
    <td style="vertical-align: top; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">No</font></td></tr>
  <tr style="vertical-align: bottom; background-color: white">
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td></tr>
  <tr>
    <td style="vertical-align: top"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">No.&nbsp;2 &ndash; Ratification of our independent registered public accounting firm</font></td>
    <td style="vertical-align: bottom">&nbsp;</td>
    <td style="vertical-align: top"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Majority: Affirmative vote of a majority of shares present and entitled to vote in person or by proxy</font></td>
    <td style="vertical-align: bottom">&nbsp;</td>
    <td style="vertical-align: top; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Yes</font></td></tr>
  </table>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Q: What if additional proposals are presented at the Annual Meeting?</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>A:</b></font>
We do not intend to bring any other matter for a vote at the Annual Meeting, and we do not know of anyone else who intends to do so. However,
with respect to any other business that properly comes before the Annual Meeting, your proxies are authorized to vote on your behalf using
their judgment.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Q: Do the directors and officers of the Company have an interest
in the outcome of the matters to be voted on?</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>A:</b></font>
Our directors and officers will not receive any special benefit as a result of the outcome of the matters to be voted on, except that
our directors will receive compensation for such service as described later in this Proxy Statement under the heading &ldquo;Executive
and Director Compensation.&rdquo;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Q: How many shares do the directors and officers of the Company
beneficially own, and how do they plan to vote their shares?</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>A:</b></font>
Directors and executive officers, who, as of the Record Date, had beneficial ownership (or had the right to acquire beneficial ownership
within 60 days following the Record Date) of approximately 20.8% of our outstanding common stock, are expected to vote, or direct the
voting of their shares, in favor of the election of the five director nominees set forth in this Proxy Statement, and in favor of the
ratification of the selection of <font style="background-color: white">Ernst&nbsp;&amp; Young LLP </font>as our independent registered
public accounting firm for the year ending December&nbsp;31, 2025.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Q: Who will count the votes?</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>A:</b></font>
Alliance Advisors will count the votes cast by proxy. A representative of Alliance Advisors will count the votes cast at the Annual Meeting
and will serve as the inspector of election.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Q: Who can attend the Annual Meeting?</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>A:</b></font>
All stockholders as of the Record Date are invited to attend the Annual Meeting.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Q: Are there any expenses associated with collecting the stockholder
votes?</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>A:</b></font>
The Company will bear the cost of preparing, assembling, printing, mailing and distributing these proxy materials and soliciting votes.
If you access the proxy materials over the Internet, you are responsible for Internet access charges you may incur. In addition, we will
request banks, brokers and other intermediaries holding shares of our common stock beneficially owned by others to obtain proxies from
the beneficial owners and will reimburse them for their reasonable expenses in so doing. Solicitation of proxies by mail may be supplemented
by telephone, by electronic communications and personal solicitation by our officers, directors and employees. We will reimburse brokerage
firms and other custodians, nominees and fiduciaries for their reasonable out-of-pocket expenses for forwarding proxy and other materials
to our stockholders. In addition, we have engaged Alliance Advisors to assist with coordinating our proxy solicitation efforts. We will
pay the costs of soliciting proxies, in addition to an estimated fee of $24,510 to Alliance Advisors for its services in serving as Inspector
of Elections, hosting and coordinating the virtual meeting, vote tabulation,&nbsp;etc. We will reimburse Alliance Advisors for any reasonable
out-of-pocket expenses it incurs. Officers and other employees of the Company may solicit proxies in person, by electronic communication
or by telephone but will receive no compensation for doing so, other than reimbursement for out-of-pocket expenses incurred.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Q: Where can you find the voting results?</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>A:</b></font>
Voting results will be reported in a Current Report on Form&nbsp;8-K, which we will file with the SEC within four business days following
the Annual Meeting.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Q: Who is our independent registered public accounting firm, and
will they be represented at the Annual Meeting?</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"></Font></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>A:</b> <font style="background-color: white">Effective May&nbsp;25,
2023, the Audit Committee approved the appointment of Ernst&nbsp;&amp; Young LLP (&ldquo;EY&rdquo;) as the Company&rsquo;s independent
registered public accounting firm for the fiscal year ending December&nbsp;31, 2023. EY is currently still serving as our independent
registered public accounting firm. </font>We expect that one or more representatives of EY will be present at the Annual Meeting. They
will have an opportunity to make a statement, if they desire, and will be available to answer appropriate questions at the end of the
Annual Meeting.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Q: Why are you being asked to ratify the selection of <font style="background-color: white">Ernst&nbsp;&amp;
Young LLP</font>?</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>A:</b></font>
Although stockholder approval of our Audit Committee&rsquo;s selection of <font style="background-color: white">Ernst&nbsp;&amp; Young
LLP </font>as our independent registered public accounting firm is not required, we believe that it is advisable to give stockholders
an opportunity to ratify this selection. If this proposal is not approved at the Annual Meeting, the Audit Committee has agreed to reconsider
its selection of <font style="background-color: white">Ernst&nbsp;&amp; Young LLP</font>, but will not be required to take any action.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b><a name="a_003"></a>BOARD OF DIRECTORS</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Our Board currently consists of five members. Upon
election of the nominees for director below at the Annual Meeting, our Board will continue to consist of five members. Biographical information
regarding the business experience of each of our directors and the primary aspects of each of our directors&rsquo; experience, qualifications,
attributes or skills that led to the conclusion that each of our directors should serve on our Board is set forth below:</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 100%">
  <tr style="vertical-align: bottom">
    <td style="border-bottom: Black 1pt solid; white-space: nowrap; font: bold 10pt Times New Roman, Times, Serif">Name</td><td style="font: bold 10pt Times New Roman, Times, Serif; white-space: nowrap; padding-bottom: 1pt">&nbsp;</td>
    <td style="border-bottom: Black 1pt solid; white-space: nowrap; font: bold 10pt Times New Roman, Times, Serif; text-align: center">Director<BR> Since</td><td style="font: bold 10pt Times New Roman, Times, Serif; white-space: nowrap; padding-bottom: 1pt">&nbsp;</td>
    <td style="border-bottom: Black 1pt solid; white-space: nowrap; font: bold 10pt Times New Roman, Times, Serif; text-align: center">Age</td><td style="font: bold 10pt Times New Roman, Times, Serif; white-space: nowrap; padding-bottom: 1pt">&nbsp;</td>
    <td style="border-bottom: Black 1pt solid; white-space: nowrap; font: bold 10pt Times New Roman, Times, Serif; text-align: center">Independent</td><td style="font: bold 10pt Times New Roman, Times, Serif; white-space: nowrap; padding-bottom: 1pt">&nbsp;</td>
    <td style="border-bottom: Black 1pt solid; white-space: nowrap; font: bold 10pt Times New Roman, Times, Serif; text-align: center">Position</td><td style="font: bold 10pt Times New Roman, Times, Serif; white-space: nowrap; padding-bottom: 1pt">&nbsp;</td>
    <td style="border-bottom: Black 1pt solid; white-space: nowrap; font: bold 10pt Times New Roman, Times, Serif; text-align: center">Audit</td><td style="font: bold 10pt Times New Roman, Times, Serif; white-space: nowrap; padding-bottom: 1pt">&nbsp;</td>
    <td style="border-bottom: Black 1pt solid; white-space: nowrap; font: bold 10pt Times New Roman, Times, Serif; text-align: center">Compensation</td><td style="font: bold 10pt Times New Roman, Times, Serif; white-space: nowrap; padding-bottom: 1pt">&nbsp;</td>
    <td style="border-bottom: Black 1pt solid; white-space: nowrap; font: bold 10pt Times New Roman, Times, Serif; text-align: center">Nominating</td></tr>
  <tr style="vertical-align: bottom; background-color: rgb(204,238,255)">
    <td style="font: 10pt Times New Roman, Times, Serif; width: 15%; text-align: left">Michael Hoffman</td><td style="font: 10pt Times New Roman, Times, Serif; width: 1%">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; width: 8%; text-align: center">2014</td><td style="font: 10pt Times New Roman, Times, Serif; width: 1%">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; width: 7%; text-align: center">74</td><td style="font: 10pt Times New Roman, Times, Serif; width: 1%">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; width: 10%; text-align: center">&radic;</td><td style="font: 10pt Times New Roman, Times, Serif; width: 1%">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; width: 25%; text-align: left">Chairman of the Board</td><td style="font: 10pt Times New Roman, Times, Serif; width: 1%">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; width: 8%; text-align: center">&radic;</td><td style="font: 10pt Times New Roman, Times, Serif; width: 1%">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; width: 10%; text-align: center">&radic;</td><td style="width: 1%; font-size: 10pt">&nbsp;</td>
    <td style="width: 10%; font-size: 10pt; text-align: center">&nbsp;</td></tr>
  <tr style="vertical-align: bottom; background-color: White">
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">Maria Maccecchini</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: center">2008</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: center">74</td><td style="font-size: 10pt">&nbsp;</td>
    <td style="font-size: 10pt; text-align: center">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">Founder, President, CEO and&#8239;Director</td><td style="font-size: 10pt">&nbsp;</td>
    <td style="font-size: 10pt; text-align: center">&nbsp;</td><td style="font-size: 10pt">&nbsp;</td>
    <td style="font-size: 10pt; text-align: center">&nbsp;</td><td style="font-size: 10pt">&nbsp;</td>
    <td style="font-size: 10pt; text-align: center">&nbsp;</td></tr>
  <tr style="vertical-align: bottom; background-color: rgb(204,238,255)">
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">Claudine Bruck</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: center">2015</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: center">69</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: center">&radic;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif">Director</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: center">&radic;</td><td style="font-size: 10pt">&nbsp;</td>
    <td style="font-size: 10pt; text-align: center">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: center">&radic;</td></tr>
  <tr style="vertical-align: bottom; background-color: White">
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">Reid McCarthy</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: center">2021</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: center">71</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: center">&radic;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif">Director</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: center">&radic;</td><td style="font-size: 10pt">&nbsp;</td>
    <td style="font-size: 10pt; text-align: center">&nbsp;</td><td style="font-size: 10pt">&nbsp;</td>
    <td style="font-size: 10pt; text-align: center">&nbsp;</td></tr>
  <tr style="vertical-align: bottom; background-color: rgb(204,238,255)">
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">Mark White</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: center">2016</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: center">69</td><td style="font-size: 10pt">&nbsp;</td>
    <td style="font-size: 10pt">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif">Director</td><td style="font-size: 10pt">&nbsp;</td>
    <td style="font-size: 10pt">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: center">&radic;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: center">&radic;</td></tr>
  </table>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Nominees for Election to the Board of Directors for a Term Expiring
at the 2026 Annual Meeting</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b><i>Michael B. Hoffman</i></b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Mr.&nbsp;Hoffman has served as Chairman of the Board and a member of
our Board since 2014. He recently was the Chief Investment Officer for the Coalition for Green Capital, which managed a loan program for
the Federal Green Bank. Since 2018, he has been the Founder and Partner at Stone Capital Partners, a private equity firm focused on renewable
energy. From 2003 to 2018, Mr.&nbsp;Hoffman was a Partner of Riverstone Holdings LLC, or Riverstone, where he was principally responsible
for investments in power and renewable energy. Before joining Riverstone, Mr.&nbsp;Hoffman was senior managing director and head of the
mergers and acquisitions advisory business of The Blackstone Group L.P., or Blackstone, where he also served on the firm&rsquo;s principal
group investment committee as well as its executive committee. Prior to joining Blackstone, Mr.&nbsp;Hoffman was managing director and
co-head of the mergers and acquisitions department at Smith Barney, Harris Upham&nbsp;&amp; Co. Mr.&nbsp;Hoffman is currently the Chief
Executive Officer of Translational Development Acquisition Corporation. His non-profit board affiliations include Rockefeller University.
Mr.&nbsp;Hoffman received his Bachelor&rsquo;s and Master&rsquo;s Degrees from Northwestern University and his M.B.A. from the Harvard
Business School. We believe Mr.&nbsp;Hoffman&rsquo;s investment and transactional experience, including as director of other life sciences
companies, qualifies him to serve on our Board.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b><i>Maria L. Maccecchini, Ph.D.</i></b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Dr.&nbsp;Maccecchini founded Annovis and has served
as President and CEO and as a director since May&nbsp;2008. She has over 30&nbsp;years of experience in neuroscience and the workings
of the brain. She was partner and director of two angel groups, Robin Hood Ventures, from 2002 to 2009, and MidAtlantic Angel Group, from
2005 to 2009. In 1992, she founded and became chief executive officer of Symphony Pharmaceuticals/Annovis, a biotech company, which was
sold in 2001 to Transgenomic. Prior to that, from 1987 to 1991 she was General Manager of Bachem Bioscience, the US subsidiary of Bachem
AG, Switzerland and Head of Molecular Biology at Mallinckrodt. Dr.&nbsp;Maccecchini conducted post-doctoral research at Caltech and the
Roche Institute of Immunology. She earned a Ph.D. in biochemistry is from the Biocenter of Basel with a two-year visiting fellowship at
The Rockefeller University. Dr.&nbsp;Maccecchini serves on several boards of biotechnology companies, organizations that promote entrepreneurship,
international trade, women and charitable organizations. She has been a lecturer at Wharton School of Business since 2016. We believe
that Dr.&nbsp;Maccecchini&rsquo;s experience in the life science industry, including as principal executive officer and manager of companies
in the pharmaceutical development business, qualifies her to serve as our President, CEO and a director.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b><i>Claudine E. Bruck, Ph.D.</i></b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Dr.&nbsp;Bruck has served as a member of our Board
since 2015. Dr.&nbsp;Bruck is co-founder and has served as Chief Executive Officer of Prolifagen LLC, a start-up company developing a
microRNA-based medicine for tissue regeneration, from June&nbsp;2016 to August&nbsp;2022, when she took the role of Board Chairman. She
is also a course Director at University of Pennsylvania&rsquo;s Institute of Translational Medicine and Therapeutics and formerly a VP
of Research for SAPVAC LLC, a BioMotiv LLC company. Dr.&nbsp;Bruck joined GlaxoSmithKline, or GSK, to build GSK&rsquo;s HIV vaccine program
in 1985. In her role in GSK&rsquo;s vaccine group, Dr.&nbsp;Bruck was instrumental in the development of GSK&rsquo;s HPV vaccine (Cervarix)
and headed their cancer vaccine program from inception to Phase 2 before joining the drug discovery group of GSK. She held several roles
in the drug discovery group, from Head of Clinical Immunology (2004-2005) to VP and Head of Biology for the Center of Excellence for External
Drug Discovery (2005-2008), to VP and Head of a newly formed Ophthalmology R&amp;D group (2008-2015). Dr.&nbsp;Bruck is a former member
of the board of directors of Navidea,&nbsp;Inc. and currently serves as a member of the board of directors of Ophidion,&nbsp;Inc. Dr.&nbsp;Bruck
has a Ph.D. in Biochemistry from the University of Brussels. She was a post-doctoral student at Harvard University Medical School and
an Assistant Professor at Tufts Medical School. We believe Dr.&nbsp;Bruck&rsquo;s experience and training in the pharmaceutical industry
and serving as an executive and director of companies in the pharmaceutical and biotechnology industries, qualifies her to serve on our
Board.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b><i>Reid S. McCarthy</i></b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Mr.&nbsp;McCarthy has served as a member of our
Board since April&nbsp;2021. He is experienced in corporate financial management, operating management, and new venture development. A
specialist in bank, bond, and equity financings, Mr.&nbsp;McCarthy retired after serving from 2016 to 2019 as CFO of JJ Haines&nbsp;&amp;
Company,&nbsp;Inc., a $400 million revenue distribution company operating internationally. Prior to that, Mr.&nbsp;McCarthy provided consulting
Chief Financial Officer services to several life sciences companies since 2011. Prior to his service as a consulting CFO, Mr.&nbsp;McCarthy
served as Chief Financial Officer of Topaz Pharmaceuticals,&nbsp;Inc. from 2007 to 2011. Mr.&nbsp;McCarthy arranged over $34 million in
capital investment to fund the development and FDA approval of this company&rsquo;s therapeutic product. Mr.&nbsp;McCarthy and his colleagues
successfully sold the company in late 2011 to Sanofi Pasteur, an international pharmaceuticals company. From 1993 to 2007 Mr.&nbsp;McCarthy
served as a founding executive of several venture capital-backed companies operating in the senior real estate, bio-metric technology,
and agribusiness industries, all of which were successfully sold. Mr.&nbsp;McCarthy's past positions include Vice President of Financing
for Trinity Capital Corporation, Director-Project Financing for ASEA Brown Boveri,&nbsp;Inc., and officer positions with New York-based
money center banks, including J.P. Morgan Chase. Mr.&nbsp;McCarthy holds an undergraduate degree in international relations from the University
of New Hampshire and an MBA in international finance from New York University. We believe Mr.&nbsp;McCarthy&rsquo;s finance background
and prior experience with a life science company qualify him to serve on our Board.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b><i>Mark White</i></b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Mr.&nbsp;White has served as a member of our Board
since 2016 and Chief Business Officer since 2024. From 2015 to 2016, Mr.&nbsp;White served as chief executive officer of Neurokine Therapeutics,
an early-stage biopharma company focused on neurodegenerative disorders. From 2002 to 2014 he served as a vice president and senior director
in Pfizer&rsquo;s worldwide marketing group and led the Inflammation/Immunology and CNS/Pain Therapeutic areas. Mr.&nbsp;White led some
of Pfizer&rsquo;s most successful global product launches including Lyrica and Xeljanz, as well as global marketing for Enbrel and Celebrex.
Before Pfizer, Mr.&nbsp;White was senior director, marketing and business development with Bracco Diagnostics, a diagnostic pharmaceutical
business with radiology and cardiology applications, and earlier in his career, he worked for Abbott, Bayer and Ortho-McNeil, in sales
and marketing roles of increasing responsibility. Mr.&nbsp;White received his Bachelor&rsquo;s and Master&rsquo;s Degrees from the University
of Missouri and his M.B.A. from the University of Chicago Booth School of Business. We believe Mr.&nbsp;White&rsquo;s experience as a
business consultant and his service as an executive of companies in the pharmaceutical industry qualifies him to serve on our Board.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Corporate Governance and Board Matters</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Our Board is responsible for the supervision of
our overall affairs. Our Board has established three standing committees: Audit Committee, Compensation Committee, and Nominating and
Corporate Governance Committee (the &ldquo;Nominating Committee&rdquo;). During the year ended December&nbsp;31, 2024, the Board held
six meetings. No director attended fewer than 75% of the total number of board meetings and the total number of committee meetings for
committees on which he or she served. Our Board does not have a policy mandating attendance at the Annual Meeting although all our members
participated virtually in our Annual Meeting in 2024. The Audit Committee, the Compensation Committee and the Nominating Committee operate
under charters adopted by the Board that govern their responsibilities. Copies of each of these charters and our Code of Business Conduct
and Ethics can be obtained free of charge from the Company&rsquo;s website, www.annovisbio.com, or by contacting the Company at the attention
of the Secretary at our offices at Annovis Bio,&nbsp;Inc., 101 Lindenwood Drive, Suite&nbsp;225, Malvern, Pennsylvania 19355. All references
to our website address are intended to be inactive textual references only and do not constitute incorporation by reference of the information
contained at or available through our website.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b><i>Leadership Structure</i></b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Company seeks to maintain an appropriate balance
between management and the Board. During the year ended December&nbsp;31, 2024, the offices of Chairman and Chief Executive Officer were
separated and, as a result, there is no other director serving as a &ldquo;lead&rdquo; director. Our Board does not have a policy mandating
the separation of the offices of Chairman of the Board and Chief Executive Officer. Our Board believes that it is important to retain
the flexibility to combine or separate the responsibilities of the offices of Chairman of the Board and Chief Executive Officer, as from
time to time it may be in the best interests of the Company. Our shareholders will receive notice of changes to such structure.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b><i>Executive Sessions of the Board</i></b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Board meets periodically, and at least annually,
in executive session without those directors who are also executive officers of the Company and any other members of management of the
Company.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b><i>Director Independence</i></b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Our Board has determined that the following with
respect to Director independence:</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellpadding="0" cellspacing="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><tr style="vertical-align: top">
<td style="width: 0.25in"></td><td style="width: 0.25in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT></font></td><td>that Michael Hoffman, Claudine Bruck and Reid McCarthy are &ldquo;independent&rdquo; within the meaning of Section&nbsp;303A.02 of
the NYSE Listed Company Manual and Rule&nbsp;10A-3 under the Securities Exchange Act of 1934, as amended;</td></tr></table>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellpadding="0" cellspacing="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><tr style="vertical-align: top">
<td style="width: 0.25in"></td><td style="width: 0.25in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT></font></td><td>that Claudine Bruck, Reid McCarthy and Michael Hoffman meet the additional test for independence for audit committee members imposed
by SEC regulations and Section&nbsp;303A.07(a)&nbsp;of the NYSE Listed Company Manual; and</td></tr></table>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellpadding="0" cellspacing="0" style="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><tr style="vertical-align: top">
<td style="width: 0.25in"></td><td style="width: 0.25in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT></font></td><td>that Michael Hoffman and Mark White meet the additional test for independence for compensation committee members imposed by Section&nbsp;303A.05(a)&nbsp;of
the NYSE Listed Company Manual. The Board is responsible for ensuring that independent directors do not have a material relationship with
us or any of our affiliates or any of our executive officers or his or her affiliates.</td></tr></table>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b><i>Removal and Appointment of Directors</i></b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Our certificate of incorporation and bylaws provide
that a director may be removed with or without cause by the holders of at least a majority of the voting power of the shares then entitled
to vote at an election of directors. Under such certificate of incorporation and bylaws, any vacancy on our Board, including a vacancy
resulting from an enlargement of our Board, may be filled only by the vote of a majority of our directors then in office. Furthermore,
such certificate of incorporation provides that the authorized number of directors may be changed only by a resolution adopted by the
majority of our Board.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b><i>Role of the Board in Risk Oversight</i></b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">One of the key functions of our Board is informed
oversight of our risk management process. Our Board does not have a standing risk management committee, but rather administers this oversight
function directly through our Board as a whole, as well as through various standing committees of our Board that address risks inherent
in their respective areas of oversight. In particular, our Board is responsible for monitoring and assessing strategic risk exposure and
our Audit Committee has the responsibility to consider and discuss our major financial risk exposures and the steps our management has
taken to monitor and control these exposures, including guidelines and policies to govern the process by which risk assessment and management
is undertaken. Our Audit Committee also monitors compliance with legal and regulatory requirements. Our Nominating Committee monitors
the effectiveness of our corporate governance practices, including whether they are successful in preventing illegal or improper liability-creating
conduct. Our Compensation Committee assesses and monitors whether any of our compensation policies and programs has the potential to encourage
excessive risk-taking. While each committee is responsible for evaluating certain risks and overseeing the management of such risks, our
entire Board is regularly informed through committee reports about such risks.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Management regularly reports on any potential material
risks to the Company at each Board meeting. Management reports regularly to the full Board, which also considers the Company&rsquo;s risk
factors. While the Board oversees the Company&rsquo;s risk management, Company management is responsible for day-to-day risk management
processes. We believe this division of responsibilities is the most effective approach for addressing the risks facing our Company and
that our Board leadership structure supports this approach.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Board Committees</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Our Audit Committee consisted of Claudine Bruck,
Reid McCarthy and Mark White from January&nbsp;1, 2024 through June&nbsp;28, 2024. After June&nbsp;28, 2024 our Audit Committee consisted
of Claudine Bruck, Reid McCarthy and Michael Hoffman. Reid McCarthy served as Audit Committee chair for the entirety of 2024. Our Compensation
Committee consists of Michael Hoffman and Mark White, with Michael Hoffman serving as chair. Our Nominating Committee consists of Claudine
Bruck and Mark White, with Claudine Bruck serving as chair. In compliance with the NYSE Listed Company Manual, all of the members of our
Audit, Compensation and Nominating Committees are independent. For the current composition of each of our Board committees, please see
the table above under &ldquo;BOARD OF DIRECTORS&rdquo;.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b><i>Audit Committee</i></b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The primary purpose of our Audit Committee is to
assist the Board in the oversight of the integrity of our accounting and financial reporting process, the audits of our financial statements,
and our compliance with legal and regulatory requirements. The functions of our Audit Committee include, among other things:</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 48px">&nbsp;</td>
    <td style="width: 24px"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT>&nbsp;</font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">appointing, approving the compensation of, and assessing the independence of our registered public accounting firm;</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 48px">&nbsp;</td>
    <td style="width: 24px"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT>&nbsp;</font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">overseeing the work of our registered public accounting firm, including through the receipt and consideration of reports from such firm;</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 48px">&nbsp;</td>
    <td style="width: 24px"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT>&nbsp;</font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">reviewing and discussing with management and the registered public accounting firm our annual and quarterly financial statements and related disclosures;</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 48px">&nbsp;</td>
    <td style="width: 24px"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT>&nbsp;</font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">coordinating our Board&rsquo;s oversight of our internal control over financial reporting and disclosure controls and procedures;</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 48px">&nbsp;</td>
    <td style="width: 24px"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT>&nbsp;</font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">discussing our risk management policies;</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 48px">&nbsp;</td>
    <td style="width: 24px"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT>&nbsp;</font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">meeting independently with our internal auditing staff, if any, our registered public accounting firm and our management;</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 48px">&nbsp;</td>
    <td style="width: 24px"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT>&nbsp;</font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">reviewing and approving or ratifying any related party transactions;</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 48px">&nbsp;</td>
    <td style="width: 24px"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT>&nbsp;</font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">establishing procedures for the treatment of complaints received by us regarding accounting, internal accounting controls or auditing matters and confidential submissions by our employees of concerns regarding questionable accounting or auditing matters;</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 48px">&nbsp;</td>
    <td style="width: 24px"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT>&nbsp;</font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">establishing procedures for the treatment of complaints received by us regarding accounting, internal accounting controls or auditing matters and confidential submissions by our employees of concerns regarding questionable accounting or auditing matters;</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.75in">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 48px">&nbsp;</td>
    <td style="width: 24px"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT>&nbsp;</font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">preparing the audit committee report required by SEC rules; and</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 48px">&nbsp;</td>
    <td style="width: 24px"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT>&nbsp;</font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">reviewing and evaluating, at least annually, our Audit Committee&rsquo;s charter.</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The financial literacy requirements of the SEC
require that each member of our Audit Committee be able to read and understand fundamental financial statements. In addition, at least
one member of our Audit Committee is qualified as an audit committee financial expert, as defined in Item 407(d)(5)&nbsp;of Regulation
S-K, and has financial sophistication in accordance with the NYSE Listed Company Manual. Our Board has determined that Reid McCarthy qualifies
as an &ldquo;audit committee financial expert&rdquo; within the meaning of SEC regulations.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Our Audit Committee met four times during our fiscal
year ended December&nbsp;31, 2024.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">For information on audit fees, see &ldquo;Proposal
2: Ratification of Independent Registered Public Accounting Firm.&rdquo;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b><i>Compensation Committee</i></b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The primary purpose of our Compensation Committee
is to assist our Board in exercising its responsibilities relating to compensation of our executive officers and employees and to administer
our equity compensation and other benefit plans. In carrying out these responsibilities, this committee reviews all components of executive
officer and employee compensation for consistency with its compensation philosophy, as in effect from time to time. The functions of our
Compensation Committee include, among other things:</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 48px; font-size: 10pt">&nbsp;</td>
    <td style="width: 24px; font-size: 10pt"><font style="font-family: Symbol; font-size: 10pt">&middot;</font><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="font-size: 10pt"><font style="font-size: 10pt">reviewing and approving, or recommending for approval by the Board, the compensation of our Chief Executive Officer;</font></td></tr>
  </table>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 48px">&nbsp;</td>
    <td style="width: 24px"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT>&nbsp;</font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">overseeing and administering our cash and equity incentive plans;</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 48px">&nbsp;</td>
    <td style="width: 24px"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT>&nbsp;</font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">reviewing and making recommendations to our Board with respect to director compensation;</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 48px">&nbsp;</td>
    <td style="width: 24px"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT>&nbsp;</font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">engaging compensation consultants or other advisors it deems appropriate to assist with its duties;</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 48px">&nbsp;</td>
    <td style="width: 24px"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT>&nbsp;</font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">reviewing and discussing annually with management our &ldquo;Compensation Discussion and Analysis&rdquo; to the extent required;</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 48px">&nbsp;</td>
    <td style="width: 24px"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT>&nbsp;</font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">preparing the annual compensation committee report required by SEC rules, to the extent required; and</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 48px">&nbsp;</td>
    <td style="width: 24px"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT>&nbsp;</font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">reviewing and evaluating, at least annually, our Compensation Committee&rsquo;s charter.</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Our Compensation Committee met two times during
our fiscal year ended December&nbsp;31, 2024.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b><i>Nominating Committee</i></b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The primary purpose of our Nominating Committee
is to assist our Board in promoting the best interests of the Company and our stockholders through the implementation of sound corporate
governance principles and practices. The functions of our Nominating Committee include, among other things:</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 48px">&nbsp;</td>
    <td style="width: 24px"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT>&nbsp;</font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">developing, overseeing and making recommendations to the Board regarding our corporate governance principles;</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 48px">&nbsp;</td>
    <td style="width: 24px"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT>&nbsp;</font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">developing, recommending to the Board, implementing and monitoring compliance with the Code of Business Conduct and Ethics;</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 48px">&nbsp;</td>
    <td style="width: 24px"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT>&nbsp;</font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">reviewing and advising the Board on composition and minimum director qualifications for the Board and each Board committee;</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 48px">&nbsp;</td>
    <td style="width: 24px"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT>&nbsp;</font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">identifying nominees for election to the Board, consistent with the qualifications and criteria approved by the Board and recommending to the Board the director nominees for the next annual meeting of stockholders;</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 48px">&nbsp;</td>
    <td style="width: 24px"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT>&nbsp;</font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">developing a self-evaluation process of the Board&rsquo;s effectiveness and overseeing the evaluation of the Board and each Board committee; and</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 48px">&nbsp;</td>
    <td style="width: 24px"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT>&nbsp;</font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">reviewing and evaluating, at least annually, our Nominating Committee&rsquo;s charter.</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">While the Nominating Committee does not have a
formal diversity policy, the Nominating Committee recommends candidates based upon many factors, including the diversity of their business
or professional experience, the diversity of their background and their array of talents and perspectives. We believe that the Nominating
Committee&rsquo;s existing nominations process is designed to identify the best possible nominees for the Board, regardless of the nominee&rsquo;s
gender, racial background, religion or ethnicity. The Nominating Committee identifies candidates through a variety of means, including
recommendations from members of the Board and suggestions from our management including our Chief Executive Officer. In addition, the
Nominating Committee considers candidates recommended by third parties, including stockholders. The Nominating Committee gives the same
consideration to candidates recommended by stockholders as those candidates recommended by members of our Board. Stockholders wishing
to recommend director candidates for consideration by the Nominating Committee may do so by writing to our Secretary and giving the recommended
candidate&rsquo;s name, biographical data and qualifications. Nominees should have a reputation for integrity, honesty and adherence to
high ethical standards, should have demonstrated business acumen, experience and ability to exercise sound judgments in matters that relate
to the current and long-term objectives of the Company, should be willing and able to contribute positively to the decision-making process
of the Company, should have a commitment to understand the Company and its industry and to regularly attend and participate in meetings
of the Board and its committees, should have the interest and ability to understand the sometimes conflicting interests of the various
constituencies of the Company, which include stockholders, employees, customers, governmental units, creditors and the general public,
and to act in the interests of all stockholders, should not have, nor appear to have, a conflict of interest that would impair the nominee&rsquo;s
ability to represent the interests of all the Company&rsquo;s stockholders and to fulfill the responsibilities of a director. Nominees
shall not be discriminated against on the basis of race, religion, national origin, sex, sexual orientation, disability or any other basis
proscribed by law. The value of diversity on the Board should be considered.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Our Nominating Committee met one time during our
fiscal year ended December&nbsp;31, 2024.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Compensation Committee Interlocks and Insider Participation</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; text-align: left; margin: 0pt 0; text-indent: 0.5in">During 2024, our Compensation Committee consisted
of Michael Hoffman and Mark White, with Michael Hoffman serving as chair. During 2024 and as of the date of this Proxy Statement, no member
of our Compensation Committee has ever been an executive officer or employee of ours and no executive officer of the Company currently
serves, or has served during the last completed year, on the board of directors, compensation committee or other committee serving an
equivalent function, of any other entity that has one or more officers serving as a member of our Board or Compensation Committee.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Stockholder Communications with the Board</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.5in">Stockholders who wish to communicate
directly with the Board, or with a particular director, may send a letter addressed to our Secretary at Annovis Bio,&nbsp;Inc., 101 Lindenwood
Drive, Suite&nbsp;225, Malvern, Pennsylvania 19355. The mailing envelope must contain a clear notation indicating that the enclosed letter
is a &ldquo;Stockholder Board Communication&rdquo; or &ldquo;Stockholder Director Communication.&rdquo; All such letters must identify
the author as a stockholder and clearly state whether the intended recipients are all members of the Board or just certain specified individual
directors. The Secretary will make copies of all such letters and circulate them to the directors addressed. If a stockholder wishes the
communication to be confidential, such stockholder must clearly indicate on the envelope that the communication is &ldquo;confidential.&rdquo;
The Secretary will then forward such communication, unopened, to the directors, or director, specified on the envelope, or if none, to
the Chairman of the Board.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><b>Delinquent Section&nbsp;16(a)&nbsp;Reports</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.5in">Section&nbsp;16(a)&nbsp;of
the Exchange Act requires the Company&rsquo;s directors, officers and stockholders who beneficially own more than 10% of any class of
equity securities of the Company registered pursuant to Section&nbsp;12 of the Exchange Act, collectively referred to herein as the &ldquo;Reporting
Persons,&rdquo; to file initial statements of beneficial ownership of securities and statements of changes in beneficial ownership of
securities with respect to the Company&rsquo;s equity securities with the SEC. All Reporting Persons are required by SEC regulation to
furnish us with copies of all reports that such Reporting Persons file with the SEC pursuant to Section&nbsp;16(a). Based solely on our
review of the copies of such reports and upon written representations of the Reporting Persons received by us, we believe that all transactions
were timely reported during the fiscal year ended 2024, with the exception of Directors Bruck, Hoffman, Maccecchni, McCarthy and White
each of which failed to timely file one report with respect to one transaction.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><b>Code of Business Conduct and Ethics</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.5in">Our Board has adopted a Code
of Business Conduct and Ethics applicable to all of our directors, executive officers and employees. The Code of Business Conduct and
Ethics outlines the principles, policies and laws that govern our activities and establishes guidelines for conduct in the workplace.
Every director, executive officer and employee is required to read the Code of Business Conduct and Ethics annually. The Nominating Committee
of our Board is responsible for overseeing the Code of Business Conduct and Ethics and must approve any waivers of the Code of Business
Conduct and Ethics for directors, executive officers or employees. We expect that any amendments to the Code of Business Conduct and Ethics,
or any waivers of its requirements, will be disclosed on our website at www.annovisbio.com/corporate-governance.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><b>ESG and Corporate Responsibility</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.5in">We continue to build a sustainable,
environmentally conscious business while fulfilling our oversight of environmental, social and governance (&ldquo;ESG&rdquo;) risks and
our approach, commitment and measurable progress relating to climate change, human capital management, sustainability and other significant
ESG matters. We are dedicated to our sustainability efforts both internally and externally.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.5in">ESG matters significantly
impact our business and operations and present evolving risks and challenges. Environmental impacts, including climate change specifically,
create short and long-term financial risks to our business globally. Climate related changes can increase the frequency and severity of
significant weather events and natural disasters. While we maintain insurance coverage to cover certain risks of losses for damage or
destruction to facilities and property and for interruption of our business, such insurance may not cover specific losses and the amount
of our insurance coverage may not be adequate to cover all of our losses. As a result, our future operating results could be materially
and adversely affected, including if our losses are not adequately or timely covered by our insurance.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.5in">Increased attention on ESG
matters, including from our customers, shareholders and other stakeholders, may lead to us expending more resources addressing these issues.
Legislative and regulatory efforts to combat climate change and address ESG issues may prove costly and burdensome for us to comply with
and will likely continue to impact us, our customers and our suppliers.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.5in">Please see the discussion
under the heading &ldquo;Human Capital&rdquo; in our Annual Report on Form&nbsp;10-K (which accompanies this Proxy Statement) for additional
information on our human capital priorities and programs. We also recognize that certain stakeholders (such as customers, employees and
non-governmental organizations) as well as some stockholders may be interested in more detailed information about our ESG programs and
sustainability efforts<b>.</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><b>Clawback Policy</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">We maintain a clawback policy as required by the
rules&nbsp;of the NYSE. Our clawback policy covers each of our current and former executive officers. The policy provides that, subject
to the limited exemptions provided by the NYSE rules, if the Company is required to restate its financial results due to material noncompliance
with financial reporting requirements under the securities laws, the Compensation Committee must reasonably and promptly seek recovery
of any cash or equity-based incentive compensation (including vested and unvested equity) paid or awarded to the executive officer, to
the extent that the compensation (i)&nbsp;was based on erroneous financial data and (ii)&nbsp;exceeded what would have been paid to the
executive officer under the restatement. Recovery applies to any such excess cash or equity-based bonus/other incentive compensation received
by any covered executive officer, while he/she was an executive officer, on or after October&nbsp;2, 2024 during the three completed fiscal
years immediately preceding the date on which the Company determines an accounting restatement is required. For more information, see
the full text of our claw-back policy, which is filed as an exhibit to our Annual Report on Form&nbsp;10-K.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Cybersecurity</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; text-align: left; margin: 0pt 0; text-indent: 0.5in">Please see the discussion under the heading &ldquo;Cybersecurity&rdquo;
in our Annual Report on Form&nbsp;10-K (which accompanies this Proxy Statement) for additional information on our cybersecurity risk management,
strategy and governance.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Review and Approval of Transactions with Related Persons</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Board has adopted a Related Person Transactions
Policy that charges the Audit Committee with the responsibility of reviewing and approving or ratifying any related person transaction.
The Audit Committee reviews related-party transactions for potential conflicts of interests or other improprieties. Under SEC rules, related
person transactions are those transactions or series of related transactions to which we are or may be a party in which the amount involved
exceeds $120,000, and in which any of our directors or executive officers or any other related person had or will have a direct or indirect
material interest, excluding, among other things, compensation arrangements with respect to employment and board membership. Our Audit
Committee could approve a related person transaction if it determines that the transaction is in our best interests. Our directors are
required to disclose to the Audit Committee or the full Board any potential conflict of interest, or personal interest in a transaction
that our Board is considering. Our executive officers are required to disclose any related person transaction to the Audit Committee.
We also poll our directors on an annual basis with respect to related person transactions and their service as an officer or director
of other entities. Any director involved in a related person transaction that is being reviewed or approved must recuse himself or herself
from participation in any related deliberation or decision. Whenever possible, the transaction should be approved in advance and if not
approved in advance, must be submitted for ratification as promptly as practical.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b><a name="a_004"></a>AUDIT COMMITTEE REPORT</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; text-align: left; margin: 0pt 0; text-indent: 0.5in">The Audit Committee of the Board assists the Board
in performing its oversight responsibilities for our financial reporting process and audit process as more fully described in the Audit
Committee&rsquo;s charter. Management has the primary responsibility for the financial statements and the reporting process. Our independent
registered public accounting firm is responsible for performing an independent audit of our financial statements in accordance with the
auditing standards of the Public Company Accounting Oversight Board (United States), or the PCAOB, and to issue a report thereon.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">In the performance of its oversight function, the
Audit Committee has reviewed and discussed our audited financial statements for the year ended December&nbsp;31, 2024 with management
and with our independent registered public accounting firm. In addition, the Audit Committee has discussed the matters required to be
discussed by PCAOB Auditing Standard No.&nbsp;1301, <i>Communications with Audit Committees</i>, which includes, among other items, matters
related to the conduct of the audit of our financial statements, with <font style="background-color: white">Ernst&nbsp;&amp; Young LLP</font>,
our independent registered public accounting firm for the year ended December&nbsp;31, 2024. The Audit Committee has also received and
reviewed the written disclosures and the letter from <font style="background-color: white">Ernst&nbsp;&amp; Young LLP </font>required
by the Public Company Accounting Oversight Board Ethics and Independence Rule&nbsp;3526, <i>Communication with Audit Committees Concerning
Independence</i> (which relates to the independent registered public accounting firm&rsquo;s independence from us) and has discussed with
<font style="background-color: white">Ernst&nbsp;&amp; Young LLP </font>their independence from us. We also considered whether any non-audit
services provided by the independent registered public accounting firm are compatible with maintaining its independence.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Based on the review and discussions referenced
above, the Audit Committee recommended to our Board that our audited financial statements be included in our Annual Report on Form&nbsp;10-K
for the year ended December&nbsp;31, 2024.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <tr style="vertical-align: bottom">
    <td style="width: 50%">&nbsp;</td>
    <td style="width: 50%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Audit Committee: Claudine Bruck, Michael Hoffman, and Reid McCarthy, Chair</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><i>The foregoing report of the Audit Committee
does not constitute soliciting material and shall not be deemed filed, incorporated by reference into or a part of any other filing by
the Company (including any future filings) under the Securities Act or the Securities Exchange Act, except to the extent the Company specifically
incorporates such report by reference therein.</i></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b><a name="a_005"></a>SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS,
DIRECTORS AND OFFICERS</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The following table sets forth certain information
known to us regarding the beneficial ownership of our common stock as of April&nbsp;28, 2025 (except where otherwise noted) by:</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 48px">&nbsp;</td>
    <td style="width: 24px"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT>&nbsp;</font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">each stockholder known by the Company to own beneficially more than 5% of our common stock;</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 48px">&nbsp;</td>
    <td style="width: 24px"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT>&nbsp;</font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">each of our named executive officers (as that term is defined later in this Proxy Statement under the heading &ldquo;Executive and Director Compensation&rdquo;);</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 48px">&nbsp;</td>
    <td style="width: 24px"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT>&nbsp;</font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">each of our directors; and</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 48px">&nbsp;</td>
    <td style="width: 24px"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT>&nbsp;</font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">all directors and executive officers as a group.</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Percentage ownership in the following table is
based on 19,486,231 shares of common stock outstanding as of April&nbsp;28, 2025. We have determined beneficial ownership in the table
in accordance with the rules&nbsp;of the SEC. In computing the number of shares beneficially owned by any person or group of persons and
the percentage ownership of that person or group, shares of common stock that may be acquired within 60 days of April&nbsp;28, 2025 subject
to options or other rights held by such person, are deemed to be beneficially owned by such person and outstanding for the calculation
of such person&rsquo;s percentage ownership. These shares are not considered to be outstanding for computing the percentage ownership
of any other person. To our knowledge, each stockholder identified in the table possesses sole voting and investment power with respect
to all shares of common stock shown as beneficially owned by such stockholder unless noted otherwise, subject to community property laws
where applicable.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 97%; margin-left: 0.25in">
  <tr style="vertical-align: bottom">
    <td style="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif">Name of Beneficial Owner (1)</td><td style="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</td>
    <td colspan="2" style="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center">Shares <BR> Beneficially<BR> Owned</td><td style="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</td><td style="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</td>
    <td colspan="2" style="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center">% of Shares<BR> Outstanding</td><td style="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt">&nbsp;</td></tr>
  <tr style="vertical-align: bottom; background-color: rgb(204,238,255)">
    <td style="font: 10pt Times New Roman, Times, Serif; width: 74%; text-align: left"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Michael Hoffman, <i>Chairman of the Board</i></font></td><td style="font: 10pt Times New Roman, Times, Serif; width: 1%">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; width: 10%; text-align: right">1,720,899</td><td style="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">(2)</td><td style="font: 10pt Times New Roman, Times, Serif; width: 1%">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; width: 10%; text-align: right">8.8</td><td style="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">%</td></tr>
  <tr style="vertical-align: bottom; background-color: White">
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Maria Maccecchini, <i>Founder, President, CEO and Director</i></font></td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">2,284,991</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">(3)</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">11.0</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">%</td></tr>
  <tr style="vertical-align: bottom; background-color: rgb(204,238,255)">
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Claudine Bruck, <i>Director</i></font></td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">125,704</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">(4)</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">*</font></td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td></tr>
  <tr style="vertical-align: bottom; background-color: White">
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Reid McCarthy, <i>Director</i></font></td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">77,703</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">(5)</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">*</font></td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td></tr>
  <tr style="vertical-align: bottom; background-color: rgb(204,238,255)">
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Mark White, <i>Director</i></font></td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">181,728</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">(6)</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">*</font></td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td></tr>
  <tr style="vertical-align: bottom; background-color: White">
    <td style="font-size: 10pt">&nbsp;</td><td style="font-size: 10pt">&nbsp;</td>
    <td style="font-size: 10pt; text-align: left">&nbsp;</td><td style="font-size: 10pt; text-align: right">&nbsp;</td><td style="font-size: 10pt; text-align: left">&nbsp;</td><td style="font-size: 10pt">&nbsp;</td>
    <td style="font-size: 10pt; text-align: left">&nbsp;</td><td style="font-size: 10pt; text-align: right">&nbsp;</td><td style="font-size: 10pt; text-align: left">&nbsp;</td></tr>
  <tr style="vertical-align: bottom; background-color: rgb(204,238,255)">
    <td style="font: bold 10pt Times New Roman, Times, Serif; text-align: left">All executive officers and directors as a group (5 persons)</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">4,391,025</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">(7)</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">20.8</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">%</td></tr>
  <tr style="vertical-align: bottom; background-color: White">
    <td style="font-size: 10pt">&nbsp;</td><td style="font-size: 10pt">&nbsp;</td>
    <td style="font-size: 10pt; text-align: left">&nbsp;</td><td style="font-size: 10pt; text-align: right">&nbsp;</td><td style="font-size: 10pt; text-align: left">&nbsp;</td><td style="font-size: 10pt">&nbsp;</td>
    <td style="font-size: 10pt; text-align: left">&nbsp;</td><td style="font-size: 10pt; text-align: right">&nbsp;</td><td style="font-size: 10pt; text-align: left">&nbsp;</td></tr>
  <tr style="vertical-align: bottom; background-color: rgb(204,238,255)">
    <td style="font: bold 10pt Times New Roman, Times, Serif; text-align: left">Other beneficial owners of more than 5% of our common stock</td><td style="font-size: 10pt">&nbsp;</td>
    <td style="font-size: 10pt; text-align: left">&nbsp;</td><td style="font-size: 10pt; text-align: right">&nbsp;</td><td style="font-size: 10pt; text-align: left">&nbsp;</td><td style="font-size: 10pt">&nbsp;</td>
    <td style="font-size: 10pt; text-align: left">&nbsp;</td><td style="font-size: 10pt; text-align: right">&nbsp;</td><td style="font-size: 10pt; text-align: left">&nbsp;</td></tr>
  <tr style="vertical-align: bottom; background-color: White">
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">CVI Investments,&nbsp;Inc.</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">1,000,000</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">(8)</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">5.1</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">%</td></tr>
  </table>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left"></p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left"></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">* Denotes beneficial ownership of less than 1%.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(1)&nbsp;Unless otherwise indicated, such individual&rsquo;s address
is c/o Annovis Bio,&nbsp;Inc., 101 Lindenwood Drive, Suite&nbsp;225, Malvern, PA 19355.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(2)&nbsp;Includes (i)&nbsp;81,259 shares of common stock issuable upon
exercise of stock options exercisable within 60 days of April&nbsp;28, 2025; and (ii)&nbsp;223,357 shares of common stock (the &ldquo;Trust
Shares&rsquo;) held by the 2018 Jane and Michael Hoffman Descendants Trust (the &ldquo;Trust&rdquo;). Jane Hoffman is one of the voting
trustees of the Trust. The address of the voting trustees is 52 E 83rd St, NY, NY 10028. Given his familial relationship with one of the
Trust&rsquo;s voting trustees, Michael Hoffman may be deemed a beneficial owner of the Trust Shares. Mr.&nbsp;Hoffman disclaims beneficial
ownership over the Trust Shares.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(3)&nbsp;Includes 1,216,532 shares of common stock issuable upon exercise
of stock options exercisable within 60 days of April&nbsp;28, 2025.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(4)&nbsp;Includes 119,137 shares of common stock issuable upon exercise
of stock options exercisable within 60 days of April&nbsp;28, 2025.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(5)&nbsp;Includes 70,398 shares of common stock issuable upon exercise
of stock options exercisable within 60 days of April&nbsp;28, 2025.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(6)&nbsp;Includes 120,561 shares of common stock issuable upon exercise
of stock options exercisable within 60 days of April&nbsp;28, 2025.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(7)&nbsp;Includes 1,607,887 shares of common stock issuable upon exercise
of stock options exercisable within 60 days of April&nbsp;28, 2025.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-indent: -0.25in">(8)&nbsp;Based on a Schedule 13G filed
with the SEC on February&nbsp;10, 2025. The address of the reporting person is P.O.&nbsp;Box 309, Ugland House, Grand Cayman.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b><a name="a_006"></a>EXECUTIVE OFFICERS</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The following are biographical summaries of our
executive officers and their ages:</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <tr style="vertical-align: bottom">
    <td style="border-bottom: black 1pt solid"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Name</b></font></td>
    <td style="padding-bottom: 1pt">&nbsp;</td>
    <td style="border-bottom: black 1pt solid; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Age</b></font></td>
    <td style="padding-bottom: 1pt">&nbsp;</td>
    <td style="border-bottom: black 1pt solid; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Position</b></font></td></tr>
  <tr style="vertical-align: bottom; background-color: White">
    <td style="width: 34%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Maria Maccecchini</font></td>
    <td style="width: 1%">&nbsp;</td>
    <td style="width: 32%; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">74</font></td>
    <td style="width: 1%">&nbsp;</td>
    <td style="width: 32%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Founder, President, CEO and Director</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Information about our President and Chief Executive
Officer, Maria Maccecchini, is included under the caption &ldquo;Board of Directors.&rdquo;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b><a name="a_007"></a>EXECUTIVE AND DIRECTOR COMPENSATION</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Summary Compensation Table</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The following table sets forth information concerning
the compensation of our named executive officers for the years ended December&nbsp;31, 2024 and 2023.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 100%">
  <tr style="vertical-align: bottom">
    <td style="border-bottom: Black 1pt solid; white-space: nowrap; font: bold 10pt Times New Roman, Times, Serif">Name and Principal Position</td><td style="font: bold 10pt Times New Roman, Times, Serif; white-space: nowrap; padding-bottom: 1pt">&nbsp;</td>
    <td colspan="2" style="border-bottom: Black 1pt solid; white-space: nowrap; font: bold 10pt Times New Roman, Times, Serif; text-align: center">Year</td><td style="font: bold 10pt Times New Roman, Times, Serif; white-space: nowrap; padding-bottom: 1pt">&nbsp;</td><td style="font: bold 10pt Times New Roman, Times, Serif; white-space: nowrap; padding-bottom: 1pt">&nbsp;</td>
    <td colspan="2" style="border-bottom: Black 1pt solid; white-space: nowrap; font: bold 10pt Times New Roman, Times, Serif; text-align: center">Salary ($)</td><td style="font: bold 10pt Times New Roman, Times, Serif; white-space: nowrap; padding-bottom: 1pt">&nbsp;</td><td style="font: bold 10pt Times New Roman, Times, Serif; white-space: nowrap; padding-bottom: 1pt">&nbsp;</td>
    <td colspan="2" style="border-bottom: Black 1pt solid; white-space: nowrap; font: bold 10pt Times New Roman, Times, Serif; text-align: center">Bonus<BR> ($)</td><td style="font: bold 10pt Times New Roman, Times, Serif; white-space: nowrap; padding-bottom: 1pt">&nbsp;</td><td style="font: bold 10pt Times New Roman, Times, Serif; white-space: nowrap; padding-bottom: 1pt">&nbsp;</td>
    <td colspan="2" style="border-bottom: Black 1pt solid; white-space: nowrap; font: bold 10pt Times New Roman, Times, Serif; text-align: center">Option<BR> Awards<BR> ($)(1)(2)</td><td style="font: bold 10pt Times New Roman, Times, Serif; white-space: nowrap; padding-bottom: 1pt">&nbsp;</td><td style="font: bold 10pt Times New Roman, Times, Serif; white-space: nowrap; padding-bottom: 1pt">&nbsp;</td>
    <td colspan="2" style="border-bottom: Black 1pt solid; white-space: nowrap; font: bold 10pt Times New Roman, Times, Serif; text-align: center">Non-Equity<BR> Incentive Plan<BR> Compensation <BR> ($)</td><td style="font: bold 10pt Times New Roman, Times, Serif; white-space: nowrap; padding-bottom: 1pt">&nbsp;</td><td style="font: bold 10pt Times New Roman, Times, Serif; white-space: nowrap; padding-bottom: 1pt">&nbsp;</td>
    <td colspan="2" style="border-bottom: Black 1pt solid; white-space: nowrap; font: bold 10pt Times New Roman, Times, Serif; text-align: center">All Other<BR> Compensation<BR> ($)(3)</td><td style="font: bold 10pt Times New Roman, Times, Serif; white-space: nowrap; padding-bottom: 1pt">&nbsp;</td><td style="font: bold 10pt Times New Roman, Times, Serif; white-space: nowrap; padding-bottom: 1pt">&nbsp;</td>
    <td colspan="2" style="border-bottom: Black 1pt solid; white-space: nowrap; font: bold 10pt Times New Roman, Times, Serif; text-align: center">Total ($)</td><td style="font: bold 10pt Times New Roman, Times, Serif; white-space: nowrap; padding-bottom: 1pt">&nbsp;</td></tr>
  <tr style="vertical-align: bottom; background-color: rgb(204,238,255)">
    <td style="font: 10pt Times New Roman, Times, Serif; width: 30%; text-align: left">Maria Maccecchini</td><td style="font: 10pt Times New Roman, Times, Serif; width: 1%">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; width: 7%; text-align: center">2024</td><td style="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; width: 1%">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; width: 7%; text-align: right">734,800</td><td style="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; width: 1%">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; width: 7%; text-align: right">-</td><td style="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; width: 1%">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; width: 7%; text-align: right">1,579,067</td><td style="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; width: 1%">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; width: 7%; text-align: right">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;-</td><td style="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; width: 1%">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; width: 7%; text-align: right">13,800</td><td style="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; width: 1%">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; width: 7%; text-align: right">2,327,667</td><td style="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</td></tr>
  <tr style="vertical-align: bottom; background-color: White">
    <td style="font: italic 10pt Times New Roman, Times, Serif; padding-left: 0.125in; text-align: left">President and Chief Executive Officer</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: center">2023</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">668,000</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">-</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">2,107,638</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">-</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">13,200</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">2,788,838</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td></tr>
  </table>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 24px; font-size: 10pt">&nbsp;</td>
    <td style="width: 24px; font-size: 10pt"><font style="font-size: 10pt">(1)</font></td>
    <td style="font-size: 10pt"><font style="font-size: 10pt">In lieu of the cash bonus to which she was entitled for the 2023 fiscal year, Dr.&nbsp;Maccecchini opted to receive options to purchase shares of common stock with a fair value equal to $548,520. In lieu of the cash bonus to which she was entitled for the 2024 fiscal year, Dr.&nbsp;Maccecchini opted to receive options to purchase shares of common stock with a fair value equal to $474,773. Those amounts are included in this column. </font></td></tr>

<tr style="vertical-align: top">
    <td style="width: 24px">&nbsp;</td>
    <td style="width: 24px"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(2)</font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Amounts shown in this column do not reflect dollar amounts actually received by our directors. Instead, these amounts reflect the aggregate grant date fair value of each stock option granted in 2023 and 2024, as determined in accordance with the provisions of Financial Accounting Standards Board Accounting Standards Codification Topic 718, Compensation&thinsp;&mdash;&thinsp;Stock Compensation. The assumptions made in the calculation of these amounts are included in Note 8 of the Notes to the Financial Statements included in our Annual Report.</font></td></tr>
  <tr style="vertical-align: top">
    <td>&nbsp;</td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(3)</font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Represents matching contributions under the Company&rsquo;s 401(k)&nbsp;retirement plan.</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Employment Agreements</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">We have entered into an employment agreement with
our named executive officer, which include provisions regarding post termination compensation. We do not have a formal severance policy
or plan applicable to our executive officers as a group. The following summaries of the employment agreements are qualified in their entirety
by reference to the text of the employment agreements, as amended, which are filed as exhibits to our Annual Report.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b><i>Maccecchini Employment Agreement</i></b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">We entered into an amended and restated employment
agreement with Dr.&nbsp;Maccecchini dated as of May&nbsp;10, 2019. On March&nbsp;24, 2020, we entered into a second amended and restated
employment agreement with Dr.&nbsp;Maccecchini. Dr.&nbsp;Maccecchini's employment agreement includes a base salary, subject to annual
review and an annual performance bonus in an amount up to 50.0% of base salary based on the achievement of certain performance goals established
by our board of directors (the &ldquo;Board&rdquo;), and such bonus may be paid in cash or equity as determined by the Board.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The employment agreement has a term commencing
on the date thereof and continuing until terminated (i)&nbsp;upon death or disability, (ii)&nbsp;for cause, (iii)&nbsp;with good reason
or without cause, or (iv)&nbsp;voluntarily. Upon a termination of Dr.&nbsp;Maccecchini's employment by us without cause or a resignation
by Dr.&nbsp;Maccecchini for good reason, Dr.&nbsp;Maccecchini is eligible to receive a continuation of her base salary for twelve months,
with such amount payable in a lump sum payment upon a change in control, as defined in the employment agreement, subject to her execution
and delivery of a general release of claims.&nbsp;If such termination occurs upon or within twelve months after a change of control, Dr.&nbsp;Maccecchini
will also be entitled to receive an amount equal to the projected target amount of her annual bonus for the calendar year in which her
employment termination occurs payable in a single lump sum. Upon such termination, Dr.&nbsp;Maccecchini is also eligible to receive reimbursement
for the medical insurance premiums at the same level as was in effect on the termination date until the earlier of (1)&nbsp;the end of
such 12-month period or (2)&nbsp;the date she becomes eligible for medical benefits through another employer.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Base Salary</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Annual base salaries are intended to provide a
fixed component of compensation to our named executive officers, reflecting their skill sets, experience, roles and responsibilities,
and are typically reviewed on an annual basis. Base salaries for our named executive officers have generally been set at levels deemed
necessary to attract and retain individuals with superior talent and were set based on feedback from our compensation consultant.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Bonus</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Our Board determined that Dr.&nbsp;Maccecchini
achieved 100% of her performance goals established for 2024. She was paid an annual performance bonus equal to 150% of her base salary
target percentage, to be received in the form of stock options, in lieu of cash bonus payment.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Outstanding Equity Awards at Fiscal Year-End</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The following table summarizes the number of shares
of common stock underlying outstanding equity incentive plan awards for each named executive officer as of December&nbsp;31, 2024.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 97%; margin-left: 0.25in">
  <tr style="vertical-align: bottom">
    <td style="font-size: 10pt; text-align: center; padding-bottom: 1pt">&nbsp;</td><td style="text-align: center; font-size: 10pt; padding-bottom: 1pt">&nbsp;</td>
    <td style="font-size: 10pt; text-align: center; padding-bottom: 1pt">&nbsp;</td><td style="font: bold 10pt Times New Roman, Times, Serif; text-align: center; padding-bottom: 1pt">&nbsp;</td>
    <td style="font: bold 10pt Times New Roman, Times, Serif; text-align: center">&nbsp;</td><td colspan="13" style="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Option Awards</b></font></td><td style="padding-bottom: 1pt; text-align: center">&nbsp;</td></tr>
  <tr style="vertical-align: bottom">
    <td style="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center">Name</td><td style="font: bold 10pt Times New Roman, Times, Serif; text-align: center; padding-bottom: 1pt">&nbsp;</td>
    <td style="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center">Grant Date</td><td style="font: bold 10pt Times New Roman, Times, Serif; text-align: center; padding-bottom: 1pt">&nbsp;</td>
    <td style="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: center">&nbsp;</td><td style="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Number of<br> Securities<br> Underlying<br> Unexercised<br> Options (#)<br> Exercisable</b></font></td><td style="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: center">&nbsp;</td><td style="font: bold 10pt Times New Roman, Times, Serif; text-align: center; padding-bottom: 1pt">&nbsp;</td>
    <td style="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: center">&nbsp;</td><td style="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Number of<br> Securities<br> Underlying<br> Unexercised<br> Options (#)<br> Unexercisable</b></font></td><td style="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: center">&nbsp;</td><td style="font: bold 10pt Times New Roman, Times, Serif; text-align: center; padding-bottom: 1pt">&nbsp;</td>
    <td style="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: center">&nbsp;</td><td style="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Option<br> Exercise<br> Price<br> ($)</b></font></td><td style="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: center">&nbsp;</td><td style="font: bold 10pt Times New Roman, Times, Serif; text-align: center; padding-bottom: 1pt">&nbsp;</td>
    <td style="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: center">&nbsp;</td><td style="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; text-align: center"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Option<br> Expiration <br> Date</b></font></td><td style="font: bold 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; text-align: center">&nbsp;</td></tr>
  <tr style="vertical-align: bottom; background-color: rgb(204,238,255)">
    <td style="font: 10pt Times New Roman, Times, Serif; width: 35%; text-align: left">Maria Maccecchini</td><td style="font: 10pt Times New Roman, Times, Serif; width: 1%">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; width: 12%; text-align: center">4/6/2018</td><td style="font: 10pt Times New Roman, Times, Serif; width: 1%">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; width: 10%; text-align: right">50,000</td><td style="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; width: 1%">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; width: 10%; text-align: right">&mdash;</td><td style="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; width: 1%">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; width: 10%; text-align: right">0.25</td><td style="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; width: 1%">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; width: 10%; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">4/6/2028</font></td><td style="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</td></tr>
  <tr style="vertical-align: bottom; background-color: White">
    <td style="font-size: 10pt">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: center">4/9/2020</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">300,000</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">&mdash;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">3.13</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">4/9/2030</font></td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td></tr>
  <tr style="vertical-align: bottom; background-color: rgb(204,238,255)">
    <td style="font-size: 10pt">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: center">7/7/2021</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">41,700</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">&mdash;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">102.85</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">7/7/2031</font></td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td></tr>
  <tr style="vertical-align: bottom; background-color: White">
    <td style="font-size: 10pt">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: center">12/6/2021</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">112,995</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">&mdash;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">20.97</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">12/6/2031</font></td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td></tr>
  <tr style="vertical-align: bottom; background-color: rgb(204,238,255)">
    <td style="font-size: 10pt">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: center">12/6/2021</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">145,305</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">&mdash;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">20.97</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">12/6/2031</font></td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td></tr>
  <tr style="vertical-align: bottom; background-color: White">
    <td style="font-size: 10pt">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: center">1/3/2022</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">19,894</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">&mdash;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">19.78</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">1/3/2032</font></td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td></tr>
  <tr style="vertical-align: bottom; background-color: rgb(204,238,255)">
    <td style="font-size: 10pt">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: center">1/3/2022</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">83,400</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">&mdash;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">19.78</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">1/3/2032</font></td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td></tr>
  <tr style="vertical-align: bottom; background-color: White">
    <td style="font-size: 10pt">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: center">1/18/2023</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">18,648</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">2,664</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">(1)</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">13.17</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">1/18/2033</font></td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td></tr>
  <tr style="vertical-align: bottom; background-color: rgb(204,238,255)">
    <td style="font-size: 10pt">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: center">11/17/2023</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">63,000</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">63,000</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">(2)</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">6.07</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">11/17/2033</font></td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td></tr>
  <tr style="vertical-align: bottom; background-color: White">
    <td style="font-size: 10pt">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: center">11/17/2023</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">63,000</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">63,000</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">(3)</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">6.07</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">11/17/2033</font></td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td></tr>
  <tr style="vertical-align: bottom; background-color: rgb(204,238,255)">
    <td style="font-size: 10pt">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: center">11/17/2023</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">108,800</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">&mdash;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">6.07</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">11/17/2033</font></td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td></tr>
  <tr style="vertical-align: bottom; background-color: White">
    <td style="font-size: 10pt">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: center">12/6/2024</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">&mdash;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">209,107</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">(4)</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">6.00</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">12/6/2034</font></td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td></tr>
  <tr style="vertical-align: bottom; background-color: rgb(204,238,255)">
    <td style="font-size: 10pt">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: center">12/6/2024</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">91,850</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">&mdash;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">6.00</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">12/6/2034</font></td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td></tr>
  </table>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.25in">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 0.25in">&nbsp;</td>
    <td style="width: 0.25in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(1)</font></td>
    <td>
    <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">On January&nbsp;18, 2023, Dr.&nbsp;Maccecchini was granted 21,312
options that vest in eight consecutive quarterly installments of 2,664 shares each on the 18th day of April, July, October&nbsp;and January&nbsp;of
each year, commencing April&nbsp;18, 2023, and continuing through January&nbsp;18, 2025.</p></td>
    </tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.25in">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.25in"></p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.25in">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 0.25in">&nbsp;</td>
    <td style="width: 0.25in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(2)</font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">On November&nbsp;17, 2023, Dr.&nbsp;Maccecchini was granted 126,000 options that vest in eight consecutive quarterly installments of 15,750 shares each on the 17th day of February, May, August&nbsp;and November&nbsp;of each year, commencing February&nbsp;17, 2024, and continuing through November&nbsp;17, 2025.</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 0.25in">&nbsp;</td>
    <td style="width: 0.25in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(3)</font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">On November&nbsp;17, 2023, Dr.&nbsp;Maccecchini was granted 126,000 options that vest in eight consecutive quarterly installments of 15,750 shares each on the 17th day of February, May, August&nbsp;and November&nbsp;of each year, commencing February&nbsp;17, 2024, and continuing through November&nbsp;17, 2025.</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.25in">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 24px; font-size: 10pt">&nbsp;</td>
    <td style="width: 24px; font-size: 10pt"><font style="font-size: 10pt">(4)</font></td>
    <td style="text-align: justify; font-size: 10pt"><font style="font-size: 10pt">On December&nbsp;6, 2024, Dr.&nbsp;Maccecchini was granted 209,107 options that vest in eight consecutive quarterly installments of 26,138 shares each on the 6th day of March, June, September&nbsp;and December&nbsp;of each year, commencing March&nbsp;6, 2025, and continuing through December&nbsp;6, 2026.</font></td></tr>
  </table>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.25in">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Other Compensation</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b><i>Employee Healthcare Benefits</i></b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">We offer healthcare benefits to our full-time employees through a group
health plan.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b><i>401(k)&nbsp;Plan</i></b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">We maintain a defined contribution 401(k)&nbsp;retirement
plan for all full-time employees. Beginning with the plan year ended December&nbsp;31, 2021, we instituted a safe-harbor company match
of 100% on employee deferrals up to 3% of compensation, plus 50% on deferrals greater than 3% but less than or equal to 5% of employee
compensation, subject to IRS compensation limits.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Compensation of Directors</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Directors who are also our employees do not receive
compensation for their service on our Board. Historically, our non-employee directors have not received compensation for their service
on our Board other than awards of stock options.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">During our fiscal year ended December&nbsp;31,
2024, we paid only equity compensation to our directors. The following table sets forth information concerning compensation for services
rendered by our directors (other than our Chief Executive Officer who was also a member of the Board) for the fiscal year ended December&nbsp;31,
2024:</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellpadding="0" cellspacing="0" align="center" style="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 90%">
  <tr style="vertical-align: bottom">
    <td style="border-bottom: Black 1pt solid; white-space: nowrap; font: bold 10pt Times New Roman, Times, Serif">Name</td><td style="font: bold 10pt Times New Roman, Times, Serif; white-space: nowrap; padding-bottom: 1pt">&nbsp;</td>
    <td colspan="2" style="border-bottom: Black 1pt solid; font: bold 10pt Times New Roman, Times, Serif; white-space: nowrap; text-align: center">Year</td><td style="font: bold 10pt Times New Roman, Times, Serif; white-space: nowrap; padding-bottom: 1pt">&nbsp;</td><td style="font: bold 10pt Times New Roman, Times, Serif; white-space: nowrap; padding-bottom: 1pt">&nbsp;</td>
    <td colspan="2" style="border-bottom: Black 1pt solid; white-space: nowrap; font: bold 10pt Times New Roman, Times, Serif; text-align: center">Option Awards ($)(1)</td><td style="font: bold 10pt Times New Roman, Times, Serif; white-space: nowrap; padding-bottom: 1pt">&nbsp;</td><td style="font: bold 10pt Times New Roman, Times, Serif; white-space: nowrap; padding-bottom: 1pt">&nbsp;</td>
    <td colspan="2" style="border-bottom: Black 1pt solid; white-space: nowrap; font: bold 10pt Times New Roman, Times, Serif; text-align: center">Total<BR> Compensation ($)(3)</td><td style="font: bold 10pt Times New Roman, Times, Serif; white-space: nowrap; padding-bottom: 1pt">&nbsp;</td></tr>
  <tr style="vertical-align: bottom; background-color: rgb(204,238,255)">
    <td style="font: 10pt Times New Roman, Times, Serif; width: 61%; text-align: left">Michael Hoffman</td><td style="font: 10pt Times New Roman, Times, Serif; width: 1%">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: center">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; width: 10%; text-align: center">2024</td><td style="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; width: 1%">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; width: 10%; text-align: right">161,991</td><td style="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; width: 1%">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; width: 10%; text-align: right">161,991</td><td style="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left">&nbsp;</td></tr>
  <tr style="vertical-align: bottom; background-color: White">
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">Reid McCarthy</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: center">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: center">2024</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">118,013</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">118,013</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td></tr>
  <tr style="vertical-align: bottom; background-color: rgb(204,238,255)">
    <td style="font: 10pt Times New Roman, Times, Serif">Mark White(2)</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: center">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: center">2024</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">118,013</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">118,013</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td></tr>
  <tr style="vertical-align: bottom; background-color: White">
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">Claudine Bruck</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: center">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: center">2024</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">118,013</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif">&nbsp;</td>
    <td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: right">118,013</td><td style="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</td></tr>
  </table>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>



<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(1)&nbsp;The Company granted to Mr.&nbsp;Hoffman 31,339 options with
an exercise price of $6.00. The Company granted to Mr.&nbsp;McCarthy 22,831 options with an exercise price of $6.00. The Company granted
to Mr.&nbsp;White 22,831 options with an exercise price of $6.00. The Company granted Ms.&nbsp;Bruck 22,831 options with an exercise
price of $6.00.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(2)&nbsp;Mr.&nbsp;White was granted 20,000 options during 2024 for
consulting services performed for the Company, as disclosed in our most recently filed Annual Report on Form&nbsp;10-K. Total compensation
with respect to these awards totaled $87,940. During 2024, 8,069 of these awards vested.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(3)&nbsp;Amounts shown in this column do not reflect dollar amounts
actually received by our directors. Instead, these amounts reflect the aggregate grant date fair value of each stock option granted in
2024 determined in accordance with the provisions of Financial Accounting Standards Board Accounting Standards Codification Topic 718,
Compensation&thinsp;&mdash;&thinsp;Stock Compensation. The assumptions made in the calculation of these amounts are included in Note 8
of the Notes to the Financial Statements included in our Annual Report.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white"><b>Issuer Purchases of
Securities</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white">There were no repurchases
of the Company&rsquo;s securities during the year ended December&nbsp;31, 2024 by or on behalf of the Company or any &ldquo;affiliated
purchaser,&rdquo; as defined in &sect; 240.10b-18(a)(3)&nbsp;of the Securities and Exchange Act of 1934, as amended.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b><a name="a_008"></a>CERTAIN RELATIONSHIPS AND RELATED PARTY TRANSACTIONS</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Since January&nbsp;1, 2024, there have been no
transactions, to which we have been a party, in which the amount involved in the transaction or series of related transactions exceeded
$120,000, and in which any of our directors, executive officers or, to our knowledge, beneficial owners of more than 5.0% of our common
stock or an affiliate or immediate family member thereof, had or will have a direct or indirect material interest, other than as discussed
below and the employment, compensation, termination, indemnification and change in control arrangements with our named executive officers,
which are described under &ldquo;Executive and Director Compensation&rdquo;.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Our Audit Committee is responsible for the review,
approval and ratification of related person transactions. The Audit Committee will review these transactions under our Code of Conduct,
which will govern conflicts of interests, among other matters, and will be applicable to our employees, officers and directors. See &ldquo;Management&mdash;Audit
Committee&rdquo; for additional information regarding related-party transactions.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><b><a name="a_009"></a>PROPOSAL 1: ELECTION OF
DIRECTORS</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Our Board consists of a number of members as established
by resolution adopted by the Board. The number of directors that presently constitute the entire Board is five. The Board has nominated
Michael Hoffman, Maria Maccecchini, Claudine Bruck, Reid McCarthy and Mark White for election as directors at the Annual Meeting. Upon
the adjournment of our 2025 Annual Meeting of Stockholders, the Board will be composed of five directors, whose term expires on the election
and qualification of successor directors at our next annual meeting of stockholders or until his or her earlier death, removal or resignation.
All of the nominees recommended by the Board are currently serving as directors, and each nominee has consented to serve as a nominee
for election to the Board, to being named in this Proxy Statement and, if elected by our stockholders, to serve as members of the Board
until our next annual meeting.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Listed above under the caption &ldquo;Board of
Directors&rdquo; are the names and biographical information of Michael Hoffman, Maria Maccecchini, Claudine Bruck, Reid McCarthy and Mark
White, the five nominees for director. The persons designated as proxies in the accompanying proxy card intend to vote <b>&ldquo;FOR&rdquo;</b>
such nominees, unless a contrary instruction is indicated on the proxy card. If for any reason any nominee should become unavailable for
election, the persons designated as proxies in the proxy card may vote the proxy for the election of another person nominated as a substitute
by the Board, if any person is so nominated. The nominees are currently directors and have consented to be named and have agreed to serve,
if elected.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Recommendation of the Board</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Board recommends a vote <b>&ldquo;FOR&rdquo;</b>
the election of Michael Hoffman, Maria Maccecchini, Claudine Bruck, Reid McCarthy and Mark White to the Board as directors.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b><a name="a_010"></a>PROPOSAL 2: RATIFICATION OF INDEPENDENT REGISTERED
PUBLIC ACCOUNTING FIRM</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Audit Committee of our Board has selected <font style="background-color: white">Ernst&nbsp;&amp;
Young LLP </font>as our independent registered public accounting firm for the fiscal year ending December&nbsp;31, 2025. We are submitting
our selection of <font style="background-color: white">Ernst&nbsp;&amp; Young LLP </font>as our independent registered public accounting
firm for ratification by our stockholders at the Annual Meeting. We expect that one or more representatives of <font style="background-color: white">Ernst&nbsp;&amp;
Young LLP</font> will be present at the Annual Meeting. They will have an opportunity to make a statement, if they desire, and will be
available to answer appropriate questions at the end of the Annual Meeting. The Audit Committee has the sole authority and responsibility
to select, appoint, evaluate and, where appropriate, discharge and replace <font style="background-color: white">Ernst&nbsp;&amp; Young
LLP </font>as our independent registered public accounting firm, and the selection of the Company&rsquo;s independent registered public
accounting firm is not required to be submitted to a vote of the stockholders for ratification. Notwithstanding the outcome of the vote
by the stockholders of the Company, the Audit Committee is not bound to retain the independent registered public accounting firm or to
replace the independent registered public accounting firm, where, in either case, after considering the outcome of the vote, the Audit
Committee determines its decision regarding the independent registered public accounting firm to be in the best interests of the Company.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white">Prior to the appointment
of Ernst&nbsp;&amp; Young LLP, WithumSmith+Brown, PC served as the Company&rsquo;s independent public accounting firm. On May&nbsp;25,
2023, the Audit Committee of the Board of Directors dismissed WithumSmith+Brown PC (&ldquo;Withum&rdquo;) as the Company&rsquo;s independent
registered public accounting firm. Withum had served as the Company&rsquo;s independent registered public accounting firm from 2019 through
the period ended May&nbsp;25, 2023.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white">Withum&rsquo;s audit reports
on the Company&rsquo;s financial statements as of and for the years ended December&nbsp;31, 2022 and 2021 did not contain an adverse opinion
or a disclaimer of opinion and were not qualified or modified as to uncertainty, audit scope or accounting principles, except for Withum&rsquo;s
report for the year ended December&nbsp;31, 2022, which contained an explanatory paragraph regarding the substantial doubt about the Company&rsquo;s
ability to continue as a&nbsp;going&nbsp;concern.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white">During the fiscal years
ended December&nbsp;31, 2022 and 2021 and the subsequent interim period through May&nbsp;25, 2023: (1)&nbsp;there were no &ldquo;disagreements&rdquo;
(as defined in Item&nbsp;304(a)(1)(iv)&nbsp;of&nbsp;Regulation S-K) with Withum on any matter of accounting principles or practices, financial
statement disclosure, or auditing scope or procedure, which disagreements, if not resolved to the satisfaction of Withum, would have caused
Withum to make reference to the subject matter of such disagreements in connection with its reports on the financial statements for such
periods and (2)&nbsp;there were no &ldquo;reportable events&rdquo; (as defined in Item&nbsp;304(a)(1)(v)&nbsp;of&nbsp;Regulation S-K),
except for the disclosure of the following material weakness in the Company&rsquo;s internal control over financial reporting as disclosed
in Part&nbsp;II,&nbsp;Item 9A of the Company&rsquo;s Annual Report on Form&nbsp;10-K for the year ended December&nbsp;31, 2022: The Company
did not design effective controls and procedures related to the proper classification of research and development expenses, which impacted
the Company&rsquo;s previously issued condensed financial statements as of and for the three months ended March&nbsp;31, 2022, three and
six months ended June&nbsp;30, 2022 and three and nine months ended September&nbsp;30, 2022. Such material weakness resulted in a restatement
of previously issued condensed financial statements as of and for the three months ended March&nbsp;31, 2022, three and six months ended
June&nbsp;30, 2022 and three and nine months ended September&nbsp;30, 2022. This reportable event was discussed among the Company&rsquo;s
management, the Audit Committee and Withum. Withum has been authorized by the Company to respond fully to the inquiries of Ernst&nbsp;&amp;
Young LLP, the successor accountant.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The following table presents fees for professional
services by Ernst&nbsp;&amp; Young LLP for the audit of Annovis&rsquo; financial statements for the fiscal years ended 2024 and 2023 and
fees billed for audit-related services, tax services and all other services for fiscal years 2024 and 2023.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 100%">
  <tr style="vertical-align: bottom">
    <td style="border-bottom: black 1pt solid"><font style="font-size: 10pt"><b>Fee Category:</b></font></td>
    <td style="padding-bottom: 1pt; text-align: center">&nbsp;</td>
    <td colspan="2" style="border-bottom: black 1pt solid; text-align: center"><font style="font-size: 10pt"><b>2023</b><br>
(WithumSmith+Brown <br>
PC)</font></td>
    <td style="padding-bottom: 1pt; text-align: center">&nbsp;</td>
    <td style="padding-bottom: 1pt; text-align: center">&nbsp;</td>
    <td colspan="2" style="border-bottom: black 1pt solid; text-align: center"><font style="font-size: 10pt"><b>2023</b><br>
(Ernst&nbsp;&amp;<br>
Young LLP)</font></td>
    <td style="padding-bottom: 1pt; text-align: center">&nbsp;</td>
    <td style="padding-bottom: 1pt; text-align: center">&nbsp;</td>
    <td colspan="2" style="border-bottom: black 1pt solid; text-align: center"><font style="font-size: 10pt"><b>2024</b><br>
(WithumSmith+Brown, <br>
PC)</font></td>
    <td style="padding-bottom: 1pt; text-align: center">&nbsp;</td>
    <td style="padding-bottom: 1pt; text-align: center">&nbsp;</td>
    <td colspan="2" style="border-bottom: black 1pt solid; text-align: center"><font style="font-size: 10pt"><b>2024</b><br>
(Ernst&nbsp;&amp;<br>
Young <br>
LLP)</font></td>
    <td style="padding-bottom: 1pt; text-align: center">&nbsp;</td></tr>
  <tr style="vertical-align: bottom; background-color: #CCEEFF">
    <td style="width: 48%"><font style="font-size: 10pt">Audit Fees</font></td>
    <td style="width: 1%">&nbsp;</td>
    <td style="width: 1%"><font style="font-size: 10pt">$</font></td>
    <td style="width: 10%; text-align: right"><font style="font-size: 10pt">27,778</font></td>
    <td style="width: 1%">&nbsp;</td>
    <td style="width: 1%">&nbsp;</td>
    <td style="width: 1%"><font style="font-size: 10pt">$</font></td>
    <td style="width: 10%; text-align: right"><font style="font-size: 10pt">260,000</font></td>
    <td style="width: 1%">&nbsp;</td>
    <td style="width: 1%">&nbsp;</td>
    <td style="width: 1%"><font style="font-size: 10pt">$</font></td>
    <td style="width: 10%; text-align: right"><font style="font-size: 10pt">&mdash;</font></td>
    <td style="width: 1%">&nbsp;</td>
    <td style="width: 1%">&nbsp;</td>
    <td style="width: 1%"><font style="font-size: 10pt">$</font></td>
    <td style="width: 10%; text-align: right"><font style="font-size: 10pt">405,000</font></td>
    <td style="width: 1%">&nbsp;</td></tr>
  <tr style="vertical-align: bottom; background-color: white">
    <td><font style="font-size: 10pt">Audit-Related Fees</font></td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td style="text-align: right"><font style="font-size: 10pt">81,000</font></td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td style="text-align: right"><font style="font-size: 10pt">50,000</font></td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td style="text-align: right"><font style="font-size: 10pt">40,040</font></td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td style="text-align: right"><font style="font-size: 10pt">115,000</font></td>
    <td>&nbsp;</td></tr>
  <tr style="vertical-align: bottom; background-color: #CCEEFF">
    <td><font style="font-size: 10pt">Tax Fees</font></td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td style="text-align: right"><font style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&mdash;</font></td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td style="text-align: right"><font style="font-size: 10pt">&mdash;</font></td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td style="text-align: right"><font style="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&mdash;</font></td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td style="text-align: right"><font style="font-size: 10pt">&mdash;</font></td>
    <td>&nbsp;</td></tr>
  <tr style="vertical-align: bottom; background-color: white">
    <td style="padding-bottom: 1pt"><font style="font-size: 10pt">All Other Fees</font></td>
    <td style="padding-bottom: 1pt">&nbsp;</td>
    <td style="border-bottom: black 1pt solid">&nbsp;</td>
    <td style="border-bottom: black 1pt solid; text-align: right"><font style="font-size: 10pt">&mdash;</font></td>
    <td style="padding-bottom: 1pt">&nbsp;</td>
    <td style="padding-bottom: 1pt">&nbsp;</td>
    <td style="border-bottom: black 1pt solid">&nbsp;</td>
    <td style="border-bottom: black 1pt solid; text-align: right"><font style="font-size: 10pt">&mdash;</font></td>
    <td style="padding-bottom: 1pt">&nbsp;</td>
    <td style="padding-bottom: 1pt">&nbsp;</td>
    <td style="border-bottom: black 1pt solid">&nbsp;</td>
    <td style="border-bottom: black 1pt solid; text-align: right"><font style="font-size: 10pt">&mdash;</font></td>
    <td style="padding-bottom: 1pt">&nbsp;</td>
    <td style="padding-bottom: 1pt">&nbsp;</td>
    <td style="border-bottom: black 1pt solid">&nbsp;</td>
    <td style="border-bottom: black 1pt solid; text-align: right"><font style="font-size: 10pt">&mdash;</font></td>
    <td style="padding-bottom: 1pt">&nbsp;</td></tr>
  <tr style="vertical-align: bottom; background-color: #CCEEFF">
    <td style="padding-bottom: 2.5pt"><font style="font-size: 10pt">Total Fees</font></td>
    <td style="padding-bottom: 2.5pt">&nbsp;</td>
    <td style="border-bottom: black 2.25pt double"><font style="font-size: 10pt">$</font></td>
    <td style="border-bottom: black 2.25pt double; text-align: right"><font style="font-size: 10pt">108,778</font></td>
    <td style="padding-bottom: 2.5pt">&nbsp;</td>
    <td style="padding-bottom: 2.5pt">&nbsp;</td>
    <td style="border-bottom: black 2.25pt double"><font style="font-size: 10pt">$</font></td>
    <td style="border-bottom: black 2.25pt double; text-align: right"><font style="font-size: 10pt">310,000</font></td>
    <td style="padding-bottom: 2.5pt">&nbsp;</td>
    <td style="padding-bottom: 2.5pt">&nbsp;</td>
    <td style="border-bottom: black 2.25pt double"><font style="font-size: 10pt">$</font></td>
    <td style="border-bottom: black 2.25pt double; text-align: right"><font style="font-size: 10pt">40,040</font></td>
    <td style="padding-bottom: 2.5pt">&nbsp;</td>
    <td style="padding-bottom: 2.5pt">&nbsp;</td>
    <td style="border-bottom: black 2.25pt double"><font style="font-size: 10pt">$</font></td>
    <td style="border-bottom: black 2.25pt double; text-align: right"><font style="font-size: 10pt">520,000</font></td>
    <td style="padding-bottom: 2.5pt">&nbsp;</td></tr>
  </table>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Audit
Fees: </b></font>Consists of fees billed for professional services rendered in connection with quarterly reviews and the audit of our
financial statements as of and for the years ended December&nbsp;31, 2024 and 2023.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Audit-Related
Fees: </b></font>Consists of fees billed for services rendered in connection with the issuance of consents, comfort letters, technical
accounting reviews and other regulatory compliance reports and reviews of documents filed with the SEC.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Tax
Fees:</b></font> There were no tax or other fees billed in 2024 or 2023 for any services other than those reported above.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">All of the above services were approved by the
Audit Committee. In accordance with the Sarbanes-Oxley Act of 2002, as amended, the Audit Committee&rsquo;s policy is to pre-approve all
audit and non-audit services provided by our independent registered public accounting firm. On an ongoing basis, management defines and
communicates specific projects and categories of service for which the advance approval of the Audit Committee is requested. The Audit
Committee reviews these requests and advises management if the Audit Committee approves the engagement of our independent registered public
accounting firm for such services.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>Recommendation of the Board</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Board recommends a vote <b>&ldquo;FOR&rdquo;</b>
the ratification of the selection of Ernst&nbsp;&amp; Young LLP as our independent registered public accounting firm for the fiscal year
ending December&nbsp;31, 2025.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b><a name="a_012"></a>STOCKHOLDER PROPOSALS AND DIRECTOR NOMINATIONS
FOR 2026<br>
ANNUAL MEETING OF STOCKHOLDERS</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Stockholders intending to present proposals at
our Annual Meeting of Stockholders to be held in 2026 and intending to have such proposals included in our next proxy statement must send
their proposals to our Secretary, in writing, at Annovis Bio,&nbsp;Inc., 101 Lindenwood Drive, Suite&nbsp;225, Malvern, Pennsylvania 19355,
pursuant to Rule&nbsp;14a-8 promulgated under the Exchange Act for inclusion in our proxy statement and form of proxy for our 2026 Annual
Meeting of Stockholders and must be received by us not later than December&nbsp;31, 2025. If the date of the 2026 Annual Meeting is changed
by more than 30 days from the 2025 meeting, we will disclose a new deadline in a Form&nbsp;10-Q or Form&nbsp;8-K. The dates referenced
below with respect to proposing an item of business at our 2026 Annual Meeting will not affect any rights of stockholders to request inclusion
of proposals in our proxy statement pursuant to Rule&nbsp;14a-8 of the Exchange Act.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">In addition, under our bylaws, a stockholder of
record on the date of the giving of the written notice to introduce a nomination or to propose an item of business must follow certain
procedures to nominate persons for election as directors or to introduce an item of business at an Annual Meeting of Stockholders. These
procedures provide that a nomination for director nominee(s)&nbsp;and/or an item of business to be introduced at an Annual Meeting of
Stockholders must be in writing and received by our Secretary at our offices at Annovis Bio,&nbsp;Inc., 101 Lindenwood Drive, Suite&nbsp;225,
Malvern, Pennsylvania 19355. We must receive written notice of your intention to introduce a nomination or to propose an item of business
at our 2026 Annual Meeting:</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 48px">&nbsp;</td>
    <td style="width: 24px"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT></font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">no earlier than December&nbsp;30, 2025; and</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 48px">&nbsp;</td>
    <td style="width: 24px"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT></font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">no later than January&nbsp;30, 2026; or</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <tr style="vertical-align: top">
    <td style="width: 48px">&nbsp;</td>
    <td style="width: 24px"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT></font></td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">if the 2026 Annual Meeting will be held be on or before May&nbsp;18, 2026 or on or after July&nbsp;17, 2026, then no earlier than the close of business on the 120th day prior to the 2026 Annual Meeting and not later than the close of business on the later of (A)&nbsp;the 90th day prior to the 2026 Annual Meeting and (B)&nbsp;the 10th day following the day on which notice of the date of the 2026 Annual Meeting was mailed or public disclosure of the date of such annual meeting was made, whichever first occurs; or (ii)&nbsp;in the case of an election of directors at a special meeting of stockholders, provided that our Board, or such person or persons requested by a majority of our Board to call special meetings, has determined that directors shall be elected at such special meeting and provided further that the nomination made by the stockholder is for one of the director positions that our Board, or such person or persons requested by a majority of our Board to call special meetings, as the case may be, has determined will be filled at such special meeting not later than the close of business on the later of (x)&nbsp;the 90th day prior to such special meeting and (y)&nbsp;the 10th day following the day on which notice of the date of such special meeting was mailed or public disclosure of the date of such special meeting was made, whichever first occurs.</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Any such notice must include all of the information
required to be in such notice pursuant to our bylaws filed with the SEC.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b><a name="a_013"></a>ANNUAL REPORT</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">A copy of our Annual Report is available to our
stockholders with this Proxy Statement as described in the Notice of Internet Availability of Proxy Materials. A paper copy can be requested
at no charge by following the instructions in the Notice of Internet Availability of Proxy Materials.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b><a name="a_014"></a>DELIVERY OF DOCUMENTS TO STOCKHOLDERS SHARING
AN ADDRESS</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Some banks, brokers and other nominee record holders
may participate in the practice of &ldquo;householding&rdquo; proxy statements, annual reports and notices of Internet availability of
proxy materials. This means that only one copy of this Proxy Statement and our Annual Report may have been sent to multiple stockholders
in your household. We will promptly deliver a separate copy of any such documents to you if you write or call our Secretary, at Annovis
Bio,&nbsp;Inc., 101 Lindenwood Drive, Suite&nbsp;225, Malvern, Pennsylvania 19355; telephone: 484-875-3192.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">If you want to receive separate copies of our Proxy
Statement and Annual Report in the future, or if you are receiving multiple copies and would like to receive only one copy for your household,
you should contact your bank, broker, or other nominee record holder, or you may contact our Secretary, in writing, at the address listed
above.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <tr style="vertical-align: bottom">
    <td style="width: 50%">&nbsp;</td>
    <td style="width: 50%"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">By Order of the Board of Directors,</font></td></tr>
  <tr style="vertical-align: bottom">
    <td>&nbsp;</td>
    <td>&nbsp;</td></tr>
  <tr style="vertical-align: bottom">
    <td>&nbsp;</td>
    <td style="border-bottom: black 1pt solid"><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/ Maria Maccecchini</font></td></tr>
  <tr style="vertical-align: bottom">
    <td>&nbsp;</td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Maria Maccecchini,</font></td></tr>
  <tr style="vertical-align: bottom">
    <td>&nbsp;</td>
    <td><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">President and Chief Executive Officer</font></td></tr>
  </table>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
<p style="font: 10pt Times New Roman, Times, Serif; margin: 0"></p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>
<div><div align="center"><div align="center"><table border="0" cellspacing="0" cellpadding="0" style="width: 100%; border-collapse: collapse"><tr style="page-break-inside: avoid"><td style="width: 92.3%; vertical-align: top; padding: 0in 5.4pt; width: 92.3%"><p style="text-align: center; margin: 0in 0in 0pt; text-align: center"><img src="tm252538d1_def14aimg002.jpg" alt="GRAPHIC" style="height: 1037px; width: 800px"></p></td><td style="width: 7.7%; vertical-align: middle; padding: 0in 5.4pt; width: 7.7%"><p style="margin: 0in 0in 0pt"><font size="1" color="white" face="Arial" style="color:white;font-size:1.0pt;">Annual Meeting of Stockholders
For Stockholders of record as of April 28, 2025.
Tuesday, June 17, 2025 10:00AM Eastern Time.
Annual Meeting will be held virtually via live webcast.
Please visit https://web.viewproxy.com/annovisbio/2025
Internet:
https://web.viewproxy.com/annovisbio/2025
 &#x2022; Cast your vote online
 &#x2022; Have your Proxy Card ready
 &#x2022; Follow the simple instructions to record your vote
Phone:
1 (866) 804-9616
 &#x2022; Use any touch tone telephone
 &#x2022; Have your Proxy Card ready
 &#x2022; Follow the simple instructions to record your vote
Mail:
 &#x2022; Mark, sign and date your Proxy Card
 &#x2022; Fold and return your Proxy Card in the
Prepaid Envelope provided
Virtual:
 &#x2022; You must register to attend the meeting
online at:
https://web.viewproxy.com/annovisbio/2025
Scan QR Code
for Digital Voting
CONTROL NUMBER
ANNOVIS BIO, INC.
FOLD HERE
PROXY
ANNUAL MEETING OF STOCKHOLDERS
ANNOVIS BIO, INC.
JUNE 17, 2025
This Proxy is solicited by the Board of Directors of Annovis Bio, Inc.,
which recommends that you vote &#x201C;FOR&#x201D; Proposals 1 and 2.
The stockholder(s) hereby appoint(s) Michael Hoffman, Maria Maccecchini, Claudine Bruck, Reid McCarthy
and Mark White, or any of them, as proxies, each with the power to appoint his or her substitute, and hereby
authorize(s) them to represent and to vote, as designated on the reverse side of this ballot, all of the shares
of common stock of Annovis Bio, Inc. that the stockholder(s) is/are entitled to vote at the Annual Meeting of
Stockholders to be held at 10:00 AM EDT on June 17, 2025 and any adjournment or postponement thereof.
The Annual Meeting of Stockholders will be held virtually. In order to attend the meeting, you must register at
https://web.viewproxy.com/annovisbio/2025 by 11:59 PM EDT on June 14, 2025. You will receive a meeting
invitation by e-mail with your unique join link along with a password prior to the meeting date. Stockholders will
be able to listen, vote and submit questions during the virtual meeting. Further instructions on how to attend and
vote at the Annual Meeting of Stockholders are contained in the Proxy Statement in the section titled &#x201C;Questions
and Answers About the Proxy Materials and Our Annual Meeting - What do I need to do to attend the Annual
Meeting virtually?&#x201D;.
This proxy, when properly executed, will be voted in the manner directed herein. If no such direction is made, this
proxy will be voted in accordance with the Board of Directors&#x2019; recommendations.
HAVE YOUR PROXY CARD READY AND PLEASE USE
ONE OF THE EASY VOTING METHODS BELOW
Mr AB Sample
Sample Street
Sample Town
Sampleshire, XXX XXX</font></p></td></tr></table></div><div style="margin-left: 2.65%; margin-right: 2.65%; page-break-after: always"><div style="border-width: 0; background-color: #000000; clear: both; height: 2pt; margin: 30pt 0pt"></div></div><div align="center"><table border="0" cellspacing="0" cellpadding="0" style="width: 100%; border-collapse: collapse"><tr style="page-break-inside: avoid"><td style="width: 92.3%; vertical-align: top; padding: 0in 5.4pt; width: 92.3%"><p style="text-align: center; margin: 0in 0in 0pt; text-align: center"><img src="tm252538d1_def14aimg003.jpg" alt="GRAPHIC" style="height: 1037px; width: 800px"></p></td><td style="width: 7.7%; vertical-align: middle; padding: 0in 5.4pt; width: 7.7%"><p style="margin: 0in 0in 0pt"><font size="1" color="white" face="Arial" style="color:white;font-size:1.0pt;">Proposals
PLEASE MARK YOUR VOTE AS THIS EXAMPLE <font style="font-family: Wingdings">&#120;</font>
THE BOARD OF DIRECTORS RECOMMENDS A VOTE &#x201C;FOR&#x201D; EACH OF THE
DIRECTORS, AND &#x201C;FOR&#x2019;&#x201D; PROPOSALS 2.
Proposal 1: To elect the five director nominees named in the accompanying
Proxy Statement;
o	FOR ALL NOMINEES LISTED BELOW
(except as marked to the contrary below)
o	WITHHOLD AUTHORITY TO VOTE FOR ALL NOMINEES LISTED BELOW
INSTRUCTION: TO WITHHOLD AUTHORITY TO VOTE FOR ONE OR MORE INDIVIDUAL
NOMINEES STRIKE A LINE THROUGH THE NOMINEE&#x2019;S NAMES BELOW:
NOMINEES: NOMINEES:
01 Michael Hoffman 05 Mark White
02 Maria Maccecchini
03 Claudine Bruck
04 Reid McCarthy
Proposal 2: To ratify the selection of Ernst &amp; Young LLP as our independent
registered public accounting firm for the fiscal year ending December 31, 2025;
and
FOR o AGAINST o ABSTAIN o
Note: To transact such other business as may properly be brought before the
Annual Meeting or any adjournment or postponement thereof.
FOLD HERE
Signatures
2025
Date
Signature(s) of Stockholders
Title (if applicable)
Note: Please sign exactly as name appears hereon. When shares are
held by joint owners, both should sign. When signing as an attorney,
executor, administrator, trustee, guardian, or corporate officer, please
give title as such.
I PLAN TO ATTEND THE ANNUAL MEETING o
Address change/Comments: If you noted any Address Changes and/
or Comments, please mark box. o
CONTROL NUMBER</font></p></td></tr></table></div><div style="margin-left: 2.65%; margin-right: 2.65%; page-break-after: avoid"><div style="border-width: 0; background-color: #000000; clear: both; height: 2pt; margin: 30pt 0pt"></div></div></div></div></body></html>
</TEXT>
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+          !__]D!

end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
