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Subsequent Events (Details) - USD ($) $ in Thousands |  | 1 Months Ended | 2 Months Ended | 20 Months Ended |
--- | --- | --- | --- | --- | ---
Feb. 02, 2022 | Feb. 28, 2022 | Feb. 25, 2022 | Dec. 31, 2021 | Feb. 17, 2022
At Market Equity Offering Program (2020 ATM) |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |
Net proceeds from issuance of common stock |  |  |  | $ 43,087 |
Common Stock | At Market Equity Offering Program (2020 ATM) |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |
Number of shares sold (in shares) |  |  |  | 3,961,074 |
Subsequent Event | At Market Equity Offering Program (2020 ATM) |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |
Net proceeds from issuance of common stock |  |  | $ 45,579 |  |
Value of shares available for sale |  |  | $ 9,414 |  |
Subsequent Event | Common Stock | At Market Equity Offering Program (2020 ATM) |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |
Number of shares sold (in shares) |  |  | 9,493,776 |  |
Subsequent Event | Janssen |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |
Upfront payment received |  | $ 40,000 |  |  |
Subsequent Event | Synaffix |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |
Collaboration Agreement Nonrefundable Execution Fee | $ 1,500 |  |  |  |
Subsequent Event | Development and Regulatory | Janssen |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |
Aggregate milestones |  | 501,000 |  |  |
Subsequent Event | Commercial | Janssen |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |
Aggregate milestones |  | $ 530,000 |  |  |
Subsequent Event | Line of Credit | Amended New Credit Facility, Combined Tranche Four and Five |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |
Maximum borrowing capacity |  |  |  |  | $ 20,000
Tranche availability duration (in days) |  |  |  |  | 90 days

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