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Summary of Significant Accounting Policies (Tables) | 12 Months Ended
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Dec. 31, 2021
Accounting Policies [Abstract] |
Schedule of cash and cash equivalents |
| Year ended December 31, 2021 |  | Year ended December 31, 2020
| Beginning of period |  | End of period |  | Beginning of period |  | End of period
Cash and cash equivalents | $ | 255,094 |  |  | $ | 177,947 |  |  | $ | 62,351 |  |  | $ | 255,094 |
Restricted cash included in other assets, noncurrent | 321 |  |  | 478 |  |  | 321 |  |  | 321 |
Total cash, cash equivalents and restricted cash per statement of cash flows | $ | 255,415 |  |  | $ | 178,425 |  |  | $ | 62,672 |  |  | $ | 255,415 |
Schedule of restricted cash |
| Year ended December 31, 2021 |  | Year ended December 31, 2020
| Beginning of period |  | End of period |  | Beginning of period |  | End of period
Cash and cash equivalents | $ | 255,094 |  |  | $ | 177,947 |  |  | $ | 62,351 |  |  | $ | 255,094 |
Restricted cash included in other assets, noncurrent | 321 |  |  | 478 |  |  | 321 |  |  | 321 |
Total cash, cash equivalents and restricted cash per statement of cash flows | $ | 255,415 |  |  | $ | 178,425 |  |  | $ | 62,672 |  |  | $ | 255,415 |
Schedule of outstanding potentially dilutive securities excluded from calculation of diluted net loss per share | The following table sets forth the outstanding potentially dilutive securities that have been excluded from the calculation of diluted net loss per share because to include them would be anti-dilutive (in common stock equivalent shares):
| Year ended December 31,
| 2021 |  | 2020 |  | 2019
Stock options | 8,342,429 |  |  | 6,112,948 |  |  | 4,720,772 |
Unvested restricted stock units | 817,609 |  |  | 716,767 |  |  | 447,336 |
Warrants | 39,474 |  |  | 39,474 |  |  | 39,474 |
| 9,199,512 |  |  | 6,869,189 |  |  | 5,207,582 |
Schedule of estimated useful life of property and equipment | Depreciation is computed using the straight-line method over the estimated useful life of each asset as follows:
Computer equipment, office equipment and software | 3 years
Laboratory equipment | 5 years
Leasehold improvements | Shorter of useful life or life of lease

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- Definition Tabular disclosure of securities (including those issuable pursuant to contingent stock agreements) that could potentially dilute basic earnings per share (EPS) in the future that were not included in the computation of diluted EPS because to do so would increase EPS amounts or decrease loss per share amounts for the period presented, by antidilutive securities. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 260 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=124432515&loc=d3e3550-109257 + Details
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