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Summary of Significant Accounting Policies (Tables)
 12 Months Ended
Dec. 31, 2021
Accounting Policies [Abstract]  
Schedule of cash and cash equivalents
Year ended December 31, 2021Year ended December 31, 2020
Beginning
of period
End
of period
Beginning
of period
End
of period
Cash and cash equivalents
$255,094 $177,947 $62,351 $255,094 
Restricted cash included in other assets, noncurrent
321 478 321 321 
Total cash, cash equivalents and restricted cash per statement of cash flows
$255,415 $178,425 $62,672 $255,415 
Schedule of restricted cash
Year ended December 31, 2021Year ended December 31, 2020
Beginning
of period
End
of period
Beginning
of period
End
of period
Cash and cash equivalents
$255,094 $177,947 $62,351 $255,094 
Restricted cash included in other assets, noncurrent
321 478 321 321 
Total cash, cash equivalents and restricted cash per statement of cash flows
$255,415 $178,425 $62,672 $255,415 
Schedule of outstanding potentially dilutive securities excluded from calculation of diluted net loss per share The following table sets forth the outstanding potentially dilutive securities that have been excluded from the calculation of diluted net loss per share because to include them would be anti-dilutive (in common stock equivalent shares):
Year ended December 31,
202120202019
Stock options8,342,429 6,112,948 4,720,772 
Unvested restricted stock units817,609 716,767 447,336 
Warrants39,474 39,474 39,474 
9,199,512 6,869,189 5,207,582 
Schedule of estimated useful life of property and equipment Depreciation is computed using the straight-line method over the estimated useful life of each asset as follows:
Computer equipment, office equipment and software3 years
Laboratory equipment5 years
Leasehold improvementsShorter of useful life or life of lease