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Stock-based compensation - Schedule of Stock-Based Compensation Expense as Reflected in the Company's Condensed Consolidated Statements of Operations and Comprehensive Loss (Details) - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended
--- | --- | ---
Sep. 30, 2022 | Sep. 30, 2021 | Sep. 30, 2022 | Sep. 30, 2021
Stock options |  |  |  |
Share-based compensation expense | $ 5,375 | $ 4,928 | $ 16,208 | $ 13,549
Research and development |  |  |  |
Stock options |  |  |  |
Share-based compensation expense | 2,890 | 2,607 | 8,569 | 7,410
General and administrative |  |  |  |
Stock options |  |  |  |
Share-based compensation expense | $ 2,485 | $ 2,321 | $ 7,639 | $ 6,139

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- Definition Amount of expense for award under share-based payment arrangement. Excludes amount capitalized. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1)(i) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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