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Collaboration agreements - Contract Assets and Liabilities (Details) - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2022
Sep. 30, 2021
Sep. 30, 2022
Sep. 30, 2021
GSK Agreement        
Contract liabilities        
Balance at Beginning of Period     $ 0  
Additions     100,000  
Deductions     655  
Balance at End of Period $ 99,345   99,345  
Amounts included in the contract liability at the beginning of the period 0   0  
Performance obligations satisfied in previous periods 0   0  
Janssen Agreement        
Contract liabilities        
Balance at Beginning of Period     0  
Additions     40,000  
Deductions     10,916  
Balance at End of Period 29,084   29,084  
Amounts included in the contract liability at the beginning of the period 4,908   0  
Performance obligations satisfied in previous periods 0   0  
License and supply agreement Merck KGaA        
Contract liabilities        
Balance at Beginning of Period     3,944 $ 3,987
Additions     0 0
Deductions     32 32
Balance at End of Period 3,912 $ 3,955 3,912 3,955
Amounts included in the contract liability at the beginning of the period 11 11 32 32
Performance obligations satisfied in previous periods $ 0 $ 0 $ 0 $ 0