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Collaboration agreements - Merck KGaA (Details)
1 Months Ended 3 Months Ended 9 Months Ended
Jun. 30, 2014
USD ($)
target
Sep. 30, 2022
USD ($)
target
Sep. 30, 2021
USD ($)
Sep. 30, 2022
USD ($)
target
Sep. 30, 2021
USD ($)
Dec. 31, 2021
USD ($)
Dec. 31, 2020
USD ($)
Dec. 31, 2017
target
Collaboration agreements                
Research and development   $ 50,639,000 $ 35,275,000 $ 127,676,000 $ 94,645,000      
Merck KGaA                
Collaboration agreements                
Proceeds from collaborators $ 12,000,000              
Number of targets designated | target 6 6   6       6
Amount of additional fees receivable when target is designated and commercial license to target is granted $ 0              
Next potential development milestone payment eligible to receive   $ 500,000   $ 500,000        
Number of targets with satisfied performance obligations | target       4        
Merck KGaA | Rights to Future Technological Improvements | Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2022-10-01                
Collaboration agreements                
Expected recognition period   10 years   10 years        
Merck KGaA | Joint Research Committee Services | Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2022-10-01                
Collaboration agreements                
Expected recognition period   5 years   5 years        
License and supply agreement Merck KGaA                
Collaboration agreements                
Deferred revenue   $ 3,912,000 3,955,000 $ 3,912,000 3,955,000 $ 3,944,000 $ 3,987,000  
Merck KGaA Supply Agreement                
Collaboration agreements                
Research and development   $ 0 $ 0 $ 0 $ 0