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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
9 Months Ended
Sep. 30, 2022
Sep. 30, 2021
Cash flows from operating activities    
Net loss $ (159,288) $ (121,077)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation 645 644
Net amortization of premiums and discounts on marketable securities (396) 0
Stock-based compensation 16,208 13,549
Other non-cash items 574 119
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets 2,459 (4,104)
Other assets 0 (617)
Accounts payable 1,153 (2,429)
Accrued expenses 11,848 16,047
Operating lease right-of-use assets 2,127 1,548
Operating lease liabilities (1,861) (1,236)
Deferred revenue 128,397 (32)
Net cash provided by (used in) operating activities 1,866 (97,588)
Cash flows from investing activities    
Maturities of marketable securities 54,000 0
Purchase of marketable securities (159,878) 0
Purchase of property and equipment (1,412) (493)
Net cash used in investing activities (107,290) (493)
Cash flows from financing activities    
Net proceeds from at-the-market facilities 110,954 33,287
Proceeds from exercise of stock options 206 1,545
Proceeds from purchases of common stock under ESPP 606 417
Payment of employee tax obligations related to vesting of restricted stock units 0 (259)
Payments under finance lease obligations (207) (139)
Net cash provided by financing activities 111,559 34,851
Increase (decrease) in cash, cash equivalents and restricted cash 6,135 (63,230)
Cash, cash equivalents and restricted cash, beginning of period 178,425 255,415
Cash, cash equivalents and restricted cash, end of period 184,560 192,185
Supplemental disclosures of non-cash activities:    
Purchases of property and equipment in accounts payable and accrued expenses 407 46
Cash paid for interest 1,746 187
Right-of-use assets obtained in exchange for operating lease liabilities 298 3,783
Right-of-use assets obtained in exchange for financing lease liabilities $ 0 $ 609