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INTANGIBLE ASSETS (Details) - USD ($)
9 Months Ended 12 Months Ended
Sep. 30, 2022
Dec. 31, 2021
Finite-Lived Intangible Assets [Line Items]    
Net Book Value $ 3,510,638  
License rights from related parties    
Finite-Lived Intangible Assets [Line Items]    
Impairment Loss   $ 16,325,000
Gross Carrying Amount 136,665,000 152,990,000
Accumulated Amortization (133,429,962) (127,877,024)
Impairment Loss   (16,325,000)
Net Book Value $ 3,235,038 $ 8,787,976
Discount rate   10.00%
License rights from related parties | Minimum    
Finite-Lived Intangible Assets [Line Items]    
Weighted Average Useful Life 3 years 3 years
License rights from related parties | Maximum    
Finite-Lived Intangible Assets [Line Items]    
Weighted Average Useful Life 5 years 5 years
License rights    
Finite-Lived Intangible Assets [Line Items]    
Gross Carrying Amount $ 3,000,000 $ 3,000,000
Accumulated Amortization $ (3,000,000) (2,750,000)
Net Book Value   $ 250,000
Weighted Average Useful Life 5 years 5 years
Software    
Finite-Lived Intangible Assets [Line Items]    
Gross Carrying Amount $ 51,784 $ 51,784
Accumulated Amortization $ (51,784) (50,908)
Net Book Value   $ 876
Weighted Average Useful Life 3 years 3 years
Trademark    
Finite-Lived Intangible Assets [Line Items]    
Gross Carrying Amount $ 10,745 $ 10,745
Accumulated Amortization (6,031) (5,359)
Net Book Value $ 4,714 $ 5,386
Weighted Average Useful Life 15 years 15 years
In-progress patent    
Finite-Lived Intangible Assets [Line Items]    
Gross Carrying Amount $ 270,886 $ 270,886
Net Book Value 270,886 270,886
Other Intangible Assets [Member]    
Finite-Lived Intangible Assets [Line Items]    
Gross Carrying Amount 333,415 333,415
Accumulated Amortization (57,815) (56,267)
Net Book Value $ 275,600 $ 277,148