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<!-- DFIN ActiveDisclosure(SM) XBRL Schema Document - http://www.dfinsolutions.com/ -->
<!-- Creation Date      : 2021-04-14T18:24:40.5595361+00:00 -->
<!-- Version            : 5.0.1.571 -->
<!-- Package ID         : 71984f5011e54a748e0ec4ed1f03fbb0 -->
<!-- Copyright (c) 2021 Donnelley Financial Solutions, Inc. All Rights Reserved. -->
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  <xsd:element id="ccel_IntangibleAssetImpairedAccumulatedImpairmentLoss" name="IntangibleAssetImpairedAccumulatedImpairmentLoss" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="ccel_SeniorCreditFacilityMember" name="SeniorCreditFacilityMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_AmendedSeniorCreditFacilityMember" name="AmendedSeniorCreditFacilityMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_SecondAmendedSeniorCreditFacilityMember" name="SecondAmendedSeniorCreditFacilityMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_TexasCapitalBankNationalAssociationMember" name="TexasCapitalBankNationalAssociationMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_PromissoryNotesMember" name="PromissoryNotesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_AmendedAndRestatedPromissoryNotesMember" name="AmendedAndRestatedPromissoryNotesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_TermLoanMember" name="TermLoanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_AmortizationOfDebtIssuanceCosts" name="AmortizationOfDebtIssuanceCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="ccel_EarningsPerShareBasicAndDilutedLineItems" name="EarningsPerShareBasicAndDilutedLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_EarningsPerShareBasicAndDilutedTable" name="EarningsPerShareBasicAndDilutedTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesIssuedButNotYetExercised" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesIssuedButNotYetExercised" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="ccel_TwoThousandSixPlanMember" name="TwoThousandSixPlanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_TwoThousandTwelvePlanMember" name="TwoThousandTwelvePlanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_ServiceBasedStockOptionsMember" name="ServiceBasedStockOptionsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_ServiceBasedRestrictedSharesMember" name="ServiceBasedRestrictedSharesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_PerformanceBasedStockOptionsMember" name="PerformanceBasedStockOptionsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_MarketBasedStockOptionsMember" name="MarketBasedStockOptionsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_CoCeoOneMember" name="CoCeoOneMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_CoCeoTwoMember" name="CoCeoTwoMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_PerformanceAndMarketBasedVestingConditionOptionsMember" name="PerformanceAndMarketBasedVestingConditionOptionsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_MarketBasedVestingConditionOptionsMember" name="MarketBasedVestingConditionOptionsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_NonQualifiedStockOptionsMember" name="NonQualifiedStockOptionsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_ChiefInformationOfficerMember" name="ChiefInformationOfficerMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_SeptemberFourthTwoThousandNineteenGrantedOptionsMember" name="SeptemberFourthTwoThousandNineteenGrantedOptionsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_FebruaryTwentySeventhTwoThousandTwentyGrantedOptionsMember" name="FebruaryTwentySeventhTwoThousandTwentyGrantedOptionsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_FairValueOfOptionsWeightedAverageValuesAbstract" name="FairValueOfOptionsWeightedAverageValuesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageNumber" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageNumber" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="ccel_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodIntrinsicValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodIntrinsicValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="ccel_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesExercisedValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesExercisedValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="ccel_RangeOneMember" name="RangeOneMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_RangeTwoMember" name="RangeTwoMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_RangeThreeMember" name="RangeThreeMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_RangeFourMember" name="RangeFourMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_RangeFiveMember" name="RangeFiveMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_RangeSixMember" name="RangeSixMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_RoyaltiesReceivableAnnually" name="RoyaltiesReceivableAnnually" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="ccel_RoyaltiesReceivables" name="RoyaltiesReceivables" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="ccel_RoyaltiesReceivablesRemainingDue" name="RoyaltiesReceivablesRemainingDue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="ccel_RoyaltyIncomeSinceInceptionOfLicenseAndRoyaltyAgreement" name="RoyaltyIncomeSinceInceptionOfLicenseAndRoyaltyAgreement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="ccel_RoyaltyCollectedSinceInceptionOfLicenseAndRoyaltyAgreement" name="RoyaltyCollectedSinceInceptionOfLicenseAndRoyaltyAgreement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="ccel_LicenseAgreementsLineItems" name="LicenseAgreementsLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_LicenseAgreementsTable" name="LicenseAgreementsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_LifecellLicenseAndAgreementMember" name="LifecellLicenseAndAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_LicenseFeeMember" name="LicenseFeeMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_ProcessingAndStorageRoyaltiesMember" name="ProcessingAndStorageRoyaltiesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_LesseeOperatingLeaseExtendedTermOfContract" name="LesseeOperatingLeaseExtendedTermOfContract" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="ccel_DisclosureOfLeaseAssetsAndLiabilitiesAbstract" name="DisclosureOfLeaseAssetsAndLiabilitiesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_LesseeOperatingLeaseLiabilityMaturityAbstract" name="LesseeOperatingLeaseLiabilityMaturityAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_DisclosureOfRemainingLeaseTermAndDiscountRatesAbstract" name="DisclosureOfRemainingLeaseTermAndDiscountRatesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_DisclosureOfSupplementalCashFlowInformationRelatedToLeasesAbstract" name="DisclosureOfSupplementalCashFlowInformationRelatedToLeasesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_PatentOptionAgreementLineItems" name="PatentOptionAgreementLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_PatentOptionAgreementTable" name="PatentOptionAgreementTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_LicensedProductAndLicensedProcessMember" name="LicensedProductAndLicensedProcessMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_FourteenDaysOfFebruaryDateTwoThreeYearTwoZeroTwoOneMember" name="FourteenDaysOfFebruaryDateTwoThreeYearTwoZeroTwoOneMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_FirstAnniversaryMember" name="FirstAnniversaryMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_SecondAnniversaryMember" name="SecondAnniversaryMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_FivePercentUponExecutionMember" name="FivePercentUponExecutionMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_TwoPointFivePercentUponCumulativeNetSalesMember" name="TwoPointFivePercentUponCumulativeNetSalesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_TwoPointFivePercentUponCumulativeNetSalesOneMember" name="TwoPointFivePercentUponCumulativeNetSalesOneMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_TwoPointFivePercentOfMarketCapMember" name="TwoPointFivePercentOfMarketCapMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_TwoPointFivePercentOfMarketCapTriggerOccursEighteenMonthsMember" name="TwoPointFivePercentOfMarketCapTriggerOccursEighteenMonthsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_TwoPointFivePercentOfMarketCapTriggerOccursTwentyFourMonthsMember" name="TwoPointFivePercentOfMarketCapTriggerOccursTwentyFourMonthsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_FullyDilutedEquityOwnershipMember" name="FullyDilutedEquityOwnershipMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="ccel_RoyaltiesTerm" name="RoyaltiesTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="ccel_LicenseFeePayable" name="LicenseFeePayable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="ccel_RoyaltiesPercentagePortionOfNetSales" name="RoyaltiesPercentagePortionOfNetSales" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="ccel_LicenseFeeTransferred" name="LicenseFeeTransferred" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="ccel_MinimumAnnualRoyaltiesDueYearTwo" name="MinimumAnnualRoyaltiesDueYearTwo" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="ccel_MinimumAnnualRoyaltiesDueYearThree" name="MinimumAnnualRoyaltiesDueYearThree" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="ccel_MinimumAnnualRoyaltiesDueYearFour" name="MinimumAnnualRoyaltiesDueYearFour" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="ccel_MinimumAnnualRoyaltiesDueYearFive" name="MinimumAnnualRoyaltiesDueYearFive" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="ccel_MinimumAnnualRoyaltiesDueAfterYearFive" name="MinimumAnnualRoyaltiesDueAfterYearFive" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="ccel_MilestonePayments" name="MilestonePayments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="ccel_CommonStockEqualFullDilutedEquityOwnershipOutstandingPercentage" name="CommonStockEqualFullDilutedEquityOwnershipOutstandingPercentage" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="ccel_AverageClosingMarketCapital" name="AverageClosingMarketCapital" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="ccel_PresentValueOfLicenseFee" name="PresentValueOfLicenseFee" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="ccel_NumberOfCommonStockValueTransferred" name="NumberOfCommonStockValueTransferred" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
</xsd:schema>
