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Accrued expenses and other current liabilities (Details) - USD ($) $ in Thousands | Sep. 30, 2018 | Dec. 31, 2017
--- | --- | ---
Accrued expenses and other current liabilities |  |
Accrued clinical and development expenditure | $ 9,566 | $ 10,065
Accrued employee expenses | 6,897 | 6,592
VAT | 3,388 | 5,741
Other accrued expenditure | 3,812 | 4,446
Other liabilities | 651 | 357
Total | $ 24,314 | $ 27,201

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