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CONDENSED CONSOLIDATED STATEMENT OF CHANGE IN EQUITY - USD ($) $ in Thousands | Common stock | Additional paid in capital | Accumulated foreign currency translation adjustments | Accumulated unrealized gains (losses) on available-for-sale debt securities | Accumulated deficit | Total
--- | --- | --- | --- | --- | --- | ---
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |
Cumulative effect of applying new accounting standards |  |  |  |  | $ 8,645 | $ 8,645
Beginning balance as adjusted | $ 854 | $ 455,401 | $ (17,867) | $ (3,774) | (222,985) | 211,629
Balance at the beginning of the period at Dec. 31, 2017 | $ 854 | 455,401 | (17,867) | (3,774) | (231,630) | 202,984
Balance at the beginning of the period (in shares) at Dec. 31, 2017 | 562,119,334 |  |  |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |
Net loss |  |  |  |  | (59,341) | (59,341)
Issuance of shares upon exercise of stock options | $ 7 | 2,926 |  |  |  | 2,933
Issuance of shares upon exercise of stock options (in shares) | 5,102,742 |  |  |  |  |
Issuance of shares upon completion of registered direct offering | $ 78 | 99,575 |  |  |  | 99,653
Issuance of shares upon completion of registered direct offering (in shares) | 60,000,000 |  |  |  |  |
Other comprehensive loss before reclassifications |  |  |  |  |  |
Foreign currency translation adjustments |  |  | 5,103 |  |  | 5,103
Unrealized holding gains on available-for-sale debt securities, net of tax of $0 |  |  |  | 1,252 |  | 1,252
Reclassification from accumulated other comprehensive loss of losses on available-for-sale debt securities included in net loss, net of tax of $0 |  |  |  | (2,473) |  | (2,473)
Share-based compensation expense |  | 12,453 |  |  |  | 12,453
Balance at the end of the period at Sep. 30, 2018 | $ 939 | $ 570,355 | $ (12,764) | $ (49) | $ (282,326) | $ 276,155
Balance at the end of the period (in shares) at Sep. 30, 2018 | 627,222,076 |  |  |  |  |

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