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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) | 9 Months Ended
--- | ---
Sep. 30, 2018 | Sep. 30, 2017
Cash flows from operating activities |  |
Net loss | $ (59,341,000) | $ (42,875,000)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation | 5,248,000 | 3,418,000
Amortization | 464,000 | 267,000
Share-based compensation expense | 12,453,000 | 7,956,000
Realized loss on available-for-sale debt securities | 2,473,000 |
Unrealized foreign exchange gain (losses) | 4,921,000 | (6,886,000)
Other | 262,000 | 606,000
Changes in operating assets and liabilities: |  |
(Increase) decrease in receivables and other operating assets | (4,140,000) | 4,180,000
Decrease (increase) in non-current operating assets | 490,000 | (484,000)
(Decrease) increase in payables and deferred revenue | (35,533,000) | 859,000
Net cash used in operating activities | (72,703,000) | (32,959,000)
Cash flows from investing activities |  |
Acquisition of property, plant and equipment | (3,823,000) | (22,791,000)
Acquisition of intangibles | (666,000) | (288,000)
Proceeds from disposal of property, plant and equipment |  | 550,000
Maturity of short-term deposits |  | 40,645,000
Investment in short-term deposits |  | (18,000,000)
Maturity or redemption of marketable securities | 114,988,000 | 7,032,000
Investment in marketable securities | (75,545,000) | (93,218,000)
Net cash provided by (used in) investing activities | 34,954,000 | (86,070,000)
Cash flows from financing activities |  |
Proceeds from issuance of common stock, net of issuance costs $347 and $4,774 | 99,653,000 | 103,167,000
Proceeds from exercise of stock options | 2,933,000 | 401,000
Net cash provided by financing activities | 102,586,000 | 103,568,000
Effect of currency exchange rate changes on cash, cash equivalents and restricted cash | 4,111,000 | 2,223,000
Net increase (decrease) in cash, cash equivalents and restricted cash | 68,948,000 | (13,238,000)
Cash, cash equivalents and restricted cash at start of period | 88,296,000 | 162,796,000
Cash, cash equivalents and restricted cash at end of period | $ 157,244,000 | $ 149,558,000

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