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Shareholders' equity - Underwritten public offering and Registered direct offering (Details) - USD ($)		9 Months Ended
	Sep. 07, 2018	Sep. 30, 2018	Sep. 30, 2017
Stockholders' equity
Proceeds from issuance of common stock		$ 99,653,000	$ 103,167,000
Common stock
Stockholders' equity
Stock offering expenses		$ 347,000	$ 4,774,000
Matrix Capital Management Company L P, New Enterprise Associates 16, L.P. New Enterprise Associates 14, L.P. and Syncona Portfolio Limited
Stockholders' equity
Issuance of shares represented by American Depositary Shares (in ADSs)	10,000,000
Share price per ADS (in dollars per share)	$ 10.00
Matrix Capital Management Company L P, New Enterprise Associates 16, L.P. New Enterprise Associates 14, L.P. and Syncona Portfolio Limited | Common stock
Stockholders' equity
Issuance of common stock (in shares)	60,000,000
Proceeds from issuance of common stock	$ 99,653,000
Stock offering expenses	$ 347,000

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