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Accrued expenses and other current liabilities (Details) - USD ($) $ in Thousands | Mar. 31, 2019 | Dec. 31, 2018
--- | --- | ---
Accrued expenses and other current liabilities |  |
Accrued clinical and development expenditure | $ 9,432 | $ 9,637
Accrued employee expenses | 4,069 | 7,553
Accrued rent and property expenses |  | 426
Other accrued expenditure | 2,027 | 2,422
Other | 299 | 316
Total | $ 15,827 | $ 20,354

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