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Accrued expenses and other current liabilities (Details) - USD ($) $ in Thousands	Mar. 31, 2019	Dec. 31, 2018
Accrued expenses and other current liabilities
Accrued clinical and development expenditure	$ 9,432	$ 9,637
Accrued employee expenses	4,069	7,553
Accrued rent and property expenses		426
Other accrued expenditure	2,027	2,422
Other	299	316
Total	$ 15,827	$ 20,354

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Accrued expenses and other liabilities, current.

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Carrying value as of the balance sheet date of obligations incurred through that date and payable for obligations related to clinical and development expenses. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).

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Carrying value as of the balance sheet date of accrued rent and property expense. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).

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Total of the carrying values as of the balance sheet date of obligations incurred through that date and payable for obligations related to services received from employees, such as accrued salaries and bonuses, payroll taxes and fringe benefits. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).

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Amount of expenses incurred but not yet paid classified as other, due within one year or the normal operating cycle, if longer.

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Amount of liabilities classified as other, due within one year or the normal operating cycle, if longer.

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