<SEC-DOCUMENT>0001415889-24-017205.txt : 20240617
<SEC-HEADER>0001415889-24-017205.hdr.sgml : 20240617
<ACCEPTANCE-DATETIME>20240617163009
ACCESSION NUMBER:		0001415889-24-017205
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20240614
FILED AS OF DATE:		20240617
DATE AS OF CHANGE:		20240617

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Clancy Paul J
		CENTRAL INDEX KEY:			0001409601
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-40925
		FILM NUMBER:		241048675

	MAIL ADDRESS:	
		STREET 1:		C/O BIOGEN IDEC INC.
		STREET 2:		14 CAMBRIDGE CENTER
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02142

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Xilio Therapeutics, Inc.
		CENTRAL INDEX KEY:			0001840233
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		IRS NUMBER:				851623397
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		828 WINTER STREET
		CITY:			WALTHAM
		STATE:			MA
		ZIP:			02451
		BUSINESS PHONE:		617-833-1027

	MAIL ADDRESS:	
		STREET 1:		828 WINTER STREET
		CITY:			WALTHAM
		STATE:			MA
		ZIP:			02451
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>form4-06172024_040604.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0508</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2024-06-14</periodOfReport>

    <issuer>
        <issuerCik>0001840233</issuerCik>
        <issuerName>Xilio Therapeutics, Inc.</issuerName>
        <issuerTradingSymbol>XLO</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001409601</rptOwnerCik>
            <rptOwnerName>Clancy Paul J</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>828 WINTER STREET</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 300</rptOwnerStreet2>
            <rptOwnerCity>WALTHAM</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>02451</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
            <isOfficer>false</isOfficer>
            <isTenPercentOwner>false</isTenPercentOwner>
            <isOther>false</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <aff10b5One>0</aff10b5One>

    <nonDerivativeTable></nonDerivativeTable>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Stock Option (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>1.02</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2024-06-14</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>25000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2034-06-13</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>25000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>25000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value></value>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">The option was granted on June 14, 2024 and will vest as to 100% of the shares underlying the option on the earlier of (i) June 14, 2025 and (ii) the Issuer's next annual meeting of stockholders following the grant date, subject to the Reporting Person's continued service to the Issuer through the vesting date.</footnote>
    </footnotes>

    <remarks>Exhibit 24 - Power of Attorney</remarks>

    <ownerSignature>
        <signatureName>/s/ Julia Walcott, Attorney-in-Fact</signatureName>
        <signatureDate>2024-06-17</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-24
<SEQUENCE>2
<FILENAME>ex24-06172024_040605.htm
<TEXT>
<!DOCTYPE html PUBLIC "-//IETF//DTD HTML//EN">
<html><head><title>ex24-06172024_040605.htm</title></head><body style="margin-top:0;font-family:Times New Roman; font-size:10pt; color:#000000">
<p style="margin:0px" align="center"><b>LIMITED POWER OF ATTORNEY FOR SECTION&nbsp;16 REPORTING OBLIGATIONS</b></p>
<p style="margin:0px">&nbsp;</p>
<p style="margin:0px; text-indent:48px">Know all by these presents, that the undersigned hereby makes, constitutes and appoints each of Ren&eacute; Russo, Christopher Frankenfield, Kevin Brennan and Julia Walcott, signing singly and each acting individually, as the undersigned's true and lawful attorney-in-fact with full power and authority as hereinafter described to:</p>
<p style="margin:0px">&nbsp;</p>
<p style="margin:0px; text-indent:48px">(1)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;execute for and on behalf of the undersigned, in the undersigned's capacity as an officer and/or director of Xilio Therapeutics,&nbsp;Inc. (the&nbsp;<b style="font-family:Arial Unicode MS,Arial;font-weight:normal;"><font style="font-family:Arial Unicode MS,Arial">&ldquo;</font></b>Company<b style="font-family:Arial Unicode MS,Arial;font-weight:normal;"><font style="font-family:Arial Unicode MS,Arial">&rdquo;</font></b>), Forms&nbsp;3, 4, and 5 (including any amendments thereto) in accordance with Section&nbsp;16(a)&nbsp;of the Securities Exchange Act of 1934 and the rules&nbsp;thereunder (the&nbsp;<b style="font-family:Arial Unicode MS,Arial;font-weight:normal;"><font style="font-family:Arial Unicode MS,Arial">&ldquo;</font></b>Exchange Act<b style="font-family:Arial Unicode MS,Arial;font-weight:normal;"><font style="font-family:Arial Unicode MS,Arial">&rdquo;</font></b>);</p>
<p style="margin:0px">&nbsp;</p>
<p style="margin:0px; text-indent:48px">(2)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;do and perform any and all acts for and on behalf of the undersigned which may be necessary or desirable to prepare, complete and execute any such Form&nbsp;3, 4, or 5, prepare, complete and execute any amendment or amendments thereto, and timely deliver and file such form with the United States Securities and Exchange Commission and any stock exchange or similar authority;</p>
<p style="margin:0px">&nbsp;</p>
<p style="margin:0px; text-indent:48px">(3)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;seek or obtain, as the undersigned<b style="font-family:Arial Unicode MS,Arial;font-weight:normal;"><font style="font-family:Arial Unicode MS,Arial">&rsquo;</font></b>s representative and on the undersigned<b style="font-family:Arial Unicode MS,Arial;font-weight:normal;"><font style="font-family:Arial Unicode MS,Arial">&rsquo;</font></b>s behalf, information regarding transactions in the Company<b style="font-family:Arial Unicode MS,Arial;font-weight:normal;"><font style="font-family:Arial Unicode MS,Arial">&rsquo;</font></b>s securities from any third party, including brokers, employee benefit plan administrators and trustees, and the undersigned hereby authorizes any such person to release any such information to such attorney-in-fact and approves and ratifies any such release of information; and</p>
<p style="margin:0px">&nbsp;</p>
<p style="margin:0px; text-indent:48px">(4)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;take any other action of any type whatsoever in connection with the foregoing which, in the opinion of such attorney-in-fact, may be of benefit to, in the best interest of, or legally required by, the undersigned, it being understood that the documents executed by such attorney-in-fact on behalf of the undersigned pursuant to this Power of Attorney shall be in such form and shall contain such terms and conditions as such attorney-in-fact may approve in such attorney-in-fact's discretion.</p>
<p style="margin:0px">&nbsp;</p>
<p style="margin:0px; text-indent:48px">The undersigned hereby grants to each such attorney-in-fact full power and authority to do and perform any and every act and thing whatsoever requisite, necessary, or proper to be done in the exercise of any of the rights and powers herein granted, as fully to all intents and purposes as the undersigned might or could do if personally present, with full power of substitution or revocation, hereby ratifying and confirming all that such attorney-in-fact, or such attorney-in-fact's substitute or substitutes, shall lawfully do or cause to be done by virtue of this power of attorney and the rights and powers herein granted. The undersigned acknowledges that the foregoing attorneys-in-fact, in serving in such capacity at the request of the undersigned, are not assuming nor relieving, nor is the Company assuming nor relieving, any of the undersigned's responsibilities to comply with Section&nbsp;16 of the Exchange Act. The undersigned acknowledges that neither the Company nor the foregoing attorneys-in-fact assume (i)&nbsp;any liability for the undersigned<b style="font-family:Arial Unicode MS,Arial;font-weight:normal;"><font style="font-family:Arial Unicode MS,Arial">&rsquo;</font></b>s responsibility to comply with the requirement of the Exchange Act, (ii)&nbsp;any liability of the undersigned for any failure to comply with such requirements, or (iii)&nbsp;any obligation or liability of the undersigned for profit disgorgement under Section&nbsp;16(b)&nbsp;of the Exchange Act.</p>
<p style="margin:0px">&nbsp;</p>
<p style="margin:0px; text-indent:48px">This Power of Attorney shall remain in full force and effect until the undersigned is no longer required to file Forms&nbsp;3, 4, and 5 with respect to the undersigned's holdings of and transactions in securities issued by the Company, unless earlier revoked by the undersigned in a signed writing delivered to the foregoing attorneys-in-fact.</p>
<p style="margin:0px">&nbsp;</p>
<p style="margin:0px; text-indent:48px">IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to be executed as of this&nbsp;12th day of June, 2024.</p>
<table style="margin-top:0px; font-size:10pt" cellpadding="0" cellspacing="0" align="center"><tr style="font-size:0"><td width="311.067"></td><td width="312.933"></td></tr><tr><td style="margin-top:0px; padding-left:4px; padding-top:0px; padding-right:4px; padding-bottom:0px" width="311.067"><p style="margin:0px">&nbsp;</p>
</td><td style="margin-top:0px; padding-left:4px; padding-top:0px; padding-right:4px; padding-bottom:0px" width="312.933"><p style="margin:0px"><br></p>
</td></tr><tr><td style="margin-top:0px; padding-left:4px; padding-top:0px; padding-right:4px; padding-bottom:0px" valign="top" width="311.067"><p style="margin:0px">&nbsp;</p>
</td><td style="margin-top:0px; padding-left:4px; padding-top:0px; padding-right:4px; padding-bottom:0px; border-bottom:1.333px solid #000000" valign="top" width="312.933"><p style="margin:0px">/s/ Paul J. Clancy</p>
</td></tr><tr><td style="margin-top:0px; padding-left:4px; padding-top:0px; padding-right:4px; padding-bottom:0px" valign="top" width="311.067"><p style="margin:0px">&nbsp;</p>
</td><td style="margin-top:0px; padding-left:4px; padding-top:0px; padding-right:4px; padding-bottom:0px" valign="top" width="312.933"><p style="margin:0px"><br></p>
<p style="margin:0px">Signature</p>
</td></tr><tr><td style="margin-top:0px; padding-left:4px; padding-top:0px; padding-right:4px; padding-bottom:0px" valign="top" width="311.067"><p style="margin:0px">&nbsp;</p>
</td><td style="margin-top:0px; padding-left:4px; padding-top:0px; padding-right:4px; padding-bottom:0px" valign="top" width="312.933"><p style="margin:0px">&nbsp;</p>
</td></tr><tr><td style="margin-top:0px; padding-left:4px; padding-top:0px; padding-right:4px; padding-bottom:0px" valign="top" width="311.067"><p style="margin:0px">&nbsp;</p>
</td><td style="margin-top:0px; padding-left:4px; padding-top:0px; padding-right:4px; padding-bottom:0px" valign="top" width="312.933"><p style="margin:0px"><br></p>
</td></tr><tr><td style="margin-top:0px; padding-left:4px; padding-top:0px; padding-right:4px; padding-bottom:0px" valign="top" width="311.067"><p style="margin:0px">&nbsp;</p>
</td><td style="margin-top:0px; padding-left:4px; padding-top:0px; padding-right:4px; padding-bottom:0px; border-bottom:1px solid #000000" valign="top" width="312.933"><p style="margin:0px">Paul J. Clancy</p>
</td></tr><tr><td style="margin-top:0px; padding-left:4px; padding-top:0px; padding-right:4px; padding-bottom:0px" valign="top" width="311.067"><p style="margin:0px"><br></p>
</td><td style="margin-top:0px; padding-left:4px; padding-top:0px; padding-right:4px; padding-bottom:0px" valign="top" width="312.933"><p style="margin:0px">Print Name</p>
</td></tr></table><p style="margin:0px"><br></p>
<p style="margin:0px"><br><br></p>
</body></html>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
