<SEC-DOCUMENT>0000899243-21-015406.txt : 20210408
<SEC-HEADER>0000899243-21-015406.hdr.sgml : 20210408
<ACCEPTANCE-DATETIME>20210408173743
ACCESSION NUMBER:		0000899243-21-015406
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20210408
FILED AS OF DATE:		20210408
DATE AS OF CHANGE:		20210408

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			RiverVest Venture Fund III, L.P.
		CENTRAL INDEX KEY:			0001601559
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-40315
		FILM NUMBER:		21815820

	BUSINESS ADDRESS:	
		STREET 1:		7733 FORSYTH BOULEVARD
		CITY:			ST. LOUIS
		STATE:			MO
		ZIP:			63105
		BUSINESS PHONE:		314-726-6700

	MAIL ADDRESS:	
		STREET 1:		7733 FORSYTH BOULEVARD
		CITY:			ST. LOUIS
		STATE:			MO
		ZIP:			63105

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			RiverVest Venture Fund IV, L.P.
		CENTRAL INDEX KEY:			0001725443
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-40315
		FILM NUMBER:		21815818

	BUSINESS ADDRESS:	
		STREET 1:		101 SOUTH HANLEY ROAD, SUITE 1850
		CITY:			ST. LOUIS
		STATE:			MO
		ZIP:			63105
		BUSINESS PHONE:		(314) 726-6700

	MAIL ADDRESS:	
		STREET 1:		101 SOUTH HANLEY ROAD, SUITE 1850
		CITY:			ST. LOUIS
		STATE:			MO
		ZIP:			63105

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			RiverVest Venture Fund III (Ohio), L.P.
		CENTRAL INDEX KEY:			0001636686
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-40315
		FILM NUMBER:		21815819

	BUSINESS ADDRESS:	
		STREET 1:		11000 CEDAR AVENUE
		STREET 2:		SUITE 100
		CITY:			CLEVELAND
		STATE:			OH
		ZIP:			44106-3502
		BUSINESS PHONE:		314-726-6700

	MAIL ADDRESS:	
		STREET 1:		11000 CEDAR AVENUE
		STREET 2:		SUITE 100
		CITY:			CLEVELAND
		STATE:			OH
		ZIP:			44106-3502

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Reneo Pharmaceuticals, Inc.
		CENTRAL INDEX KEY:			0001637715
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				472309515
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		P.O. BOX 675614
		CITY:			RANCHO SANTA FE
		STATE:			CA
		ZIP:			92067
		BUSINESS PHONE:		619-733-3852

	MAIL ADDRESS:	
		STREET 1:		P.O. BOX 675614
		CITY:			RANCHO SANTA FE
		STATE:			CA
		ZIP:			92067
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>doc3.xml
<DESCRIPTION>FORM 3 SUBMISSION
<TEXT>
<XML>
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<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2021-04-08</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001637715</issuerCik>
        <issuerName>Reneo Pharmaceuticals, Inc.</issuerName>
        <issuerTradingSymbol>RPHM</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001601559</rptOwnerCik>
            <rptOwnerName>RiverVest Venture Fund III, L.P.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>101 S. HANLEY ROAD, SUITE 1850</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>ST. LOUIS</rptOwnerCity>
            <rptOwnerState>MO</rptOwnerState>
            <rptOwnerZipCode>63105</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001636686</rptOwnerCik>
            <rptOwnerName>RiverVest Venture Fund III (Ohio), L.P.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>101 S. HANLEY ROAD, SUITE 1850</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>ST. LOUIS</rptOwnerCity>
            <rptOwnerState>MO</rptOwnerState>
            <rptOwnerZipCode>63105</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001725443</rptOwnerCik>
            <rptOwnerName>RiverVest Venture Fund IV, L.P.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>101 S. HANLEY ROAD, SUITE 1850</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>ST. LOUIS</rptOwnerCity>
            <rptOwnerState>MO</rptOwnerState>
            <rptOwnerZipCode>63105</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>279342</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnote</value>
                    <footnoteId id="F1"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Series A Preferred Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <footnoteId id="F2"/>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F2"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F2"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>1100765</value>
                    <footnoteId id="F2"/>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnotes</value>
                    <footnoteId id="F3"/>
                    <footnoteId id="F4"/>
                    <footnoteId id="F5"/>
                    <footnoteId id="F7"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Series B Preferred Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <footnoteId id="F2"/>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F2"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F2"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>829113</value>
                    <footnoteId id="F2"/>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnotes</value>
                    <footnoteId id="F6"/>
                    <footnoteId id="F7"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">RiverVest Venture Fund III, L.P. (&quot;RiverVest III&quot;) owns 265,263 shares of Common Stock.  RiverVest Venture Fund III (Ohio), L.P. (&quot;RiverVest (Ohio) III&quot;) owns 14,079 shares of Common Stock.</footnote>
        <footnote id="F2">Each share of Series A Preferred Stock and Series B Preferred Stock has no expiration date and are convertible at any time at the election of the holder without payment of further consideration.  Each share of Series A Preferred Stock and Series B Preferred Stock will automatically convert into 1 share of Common Stock for each 4.4748 shares of Preferred Stock based upon the conversion price currently in effect. Share numbers (including those noted in the footnotes below) give effect to such conversion in connection with the closing of the Issuer's initial public offering.</footnote>
        <footnote id="F3">RiverVest III owns 62,831 shares of Series A Preferred Stock.  RiverVest (Ohio) III owns 3,334 shares of Series A Preferred Stock.  RiverVest Venture Fund IV, L.P. (&quot;RiverVest IV&quot;) owns 1,034,600 shares of Series A Preferred Stock.</footnote>
        <footnote id="F4">The shares held by RiverVest III are indirectly held by RiverVest Venture Partners III, L.P. (&quot;RiverVest Partners III&quot;), which is the general partner of RiverVest III. The shares held by RiverVest (Ohio) III are indirectly held by RiverVest Venture Partners III (Ohio), LLC (&quot;RiverVest Partners (Ohio) III&quot;), which is the general partner of RiverVest (Ohio) III. RiverVest Partners III is the sole member of RiverVest Partners (Ohio) III. RiverVest Venture Partners III, LLC is the general partner of RiverVest Partners III.</footnote>
        <footnote id="F5">The individual managers of RiverVest Ventures Partners III, LLC are Thomas C. Melzer, Jay Schmelter and John P. McKearn, Ph.D. RiverVest Partners III, RiverVest Partners (Ohio) III, RiverVest Venture Partners III, LLC and each of the individual managers share voting and dispositive power with regard to the Issuer's securities directly held by RiverVest Venture Fund III, L.P. and RiverVest Venture Fund III (Ohio), L.P.</footnote>
        <footnote id="F6">RiverVest IV owns 829,113 shares of Series B Preferred Stock.</footnote>
        <footnote id="F7">The shares held by RiverVest IV are indirectly held by RiverVest Venture Partners IV, L.P., its general partner (&quot;RiverVest Partners IV&quot;). RiverVest Venture Partners IV, LLC is the general partner of RiverVest Partners IV.  The individual managers of RiverVest Ventures Partners IV, LLC are Jay Schmelter, John P. McKearn, Ph.D. and Niall O'Donnell, a member of the Issuer's board of directors. RiverVest Partners IV, RiverVest Venture Partners IV, LLC and each of the individual managers share voting and dispositive power with regard to the Company's securities directly held by RiverVest IV.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>/s/ Jay Schmelter, Manager of RiverVest Venture Partners III, LLC</signatureName>
        <signatureDate>2021-04-08</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Jay Schmelter, Manager of RiverVest Venture Partners IV, LLC</signatureName>
        <signatureDate>2021-04-08</signatureDate>
    </ownerSignature>
</ownershipDocument>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
