<SEC-DOCUMENT>0001209191-21-026826.txt : 20210415
<SEC-HEADER>0001209191-21-026826.hdr.sgml : 20210415
<ACCEPTANCE-DATETIME>20210415161655
ACCESSION NUMBER:		0001209191-21-026826
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20210413
FILED AS OF DATE:		20210415
DATE AS OF CHANGE:		20210415

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			O'Donnell Niall
		CENTRAL INDEX KEY:			0001780235

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-40315
		FILM NUMBER:		21828676

	MAIL ADDRESS:	
		STREET 1:		C/O RIVERVEST VENTURE PARTNERS
		STREET 2:		101 SOUTH HANLEY RD., STE 1850
		CITY:			ST. LOUIS
		STATE:			MO
		ZIP:			63105

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Reneo Pharmaceuticals, Inc.
		CENTRAL INDEX KEY:			0001637715
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				472309515
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		P.O. BOX 675614
		CITY:			RANCHO SANTA FE
		STATE:			CA
		ZIP:			92067
		BUSINESS PHONE:		619-733-3852

	MAIL ADDRESS:	
		STREET 1:		P.O. BOX 675614
		CITY:			RANCHO SANTA FE
		STATE:			CA
		ZIP:			92067
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>doc4.xml
<DESCRIPTION>FORM 4 SUBMISSION
<TEXT>
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    <periodOfReport>2021-04-13</periodOfReport>

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    <issuer>
        <issuerCik>0001637715</issuerCik>
        <issuerName>Reneo Pharmaceuticals, Inc.</issuerName>
        <issuerTradingSymbol>RPHM</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001780235</rptOwnerCik>
            <rptOwnerName>O'Donnell Niall</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O RENEO PHARMACEUTICALS, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>12230 EL CAMINO REAL, SUITE 230</rptOwnerStreet2>
            <rptOwnerCity>SAN DIEGO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>92130</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
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                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2021-04-13</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>C</transactionCode>
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            <transactionTimeliness>
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                    <value>I</value>
                </directOrIndirectOwnership>
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                    <value>By RiverVest Venture Fund IV, L.P.</value>
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        </nonDerivativeTransaction>
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                    <footnoteId id="F2"/>
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        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
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            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>200000</value>
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                <transactionPricePerShare>
                    <value>15.00</value>
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            </ownershipNature>
        </nonDerivativeTransaction>
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    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Series A Preferred Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <footnoteId id="F1"/>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2021-04-13</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>C</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
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            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>4629630</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0.00</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F1"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>1034600</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
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                <sharesOwnedFollowingTransaction>
                    <value>0</value>
                </sharesOwnedFollowingTransaction>
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            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
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                    <value>By RiverVest Venture Fund IV, L.P.</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeTransaction>
        <derivativeTransaction>
            <securityTitle>
                <value>Series B Preferred Stock</value>
            </securityTitle>
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                <footnoteId id="F1"/>
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                <value>2021-04-13</value>
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                <value></value>
            </transactionTimeliness>
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                <transactionShares>
                    <value>3710116</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0.00</value>
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                    <value>D</value>
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                <footnoteId id="F1"/>
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                </directOrIndirectOwnership>
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                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeTransaction>
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    <footnotes>
        <footnote id="F1">All outstanding shares of Preferred Stock automatically converted into shares of Common Stock immediately prior to the closing of the Issuer's initial public offering, for no additional consideration at a rate of 1 share of Common Stock for each 4.4748 shares of Preferred Stock. The Preferred Stock had no expiration date.</footnote>
        <footnote id="F2">The shares held by RiverVest Venture Fund IV, L.P. (&quot;RiverVest Fund IV&quot;)  are indirectly held by RiverVest Venture Partners IV, L.P., its general partner (&quot;RiverVest Partners IV&quot;). RiverVest Venture Partners IV, LLC is the general partner of RiverVest Partners IV. The individual managers of RiverVest Ventures Partners IV, LLC are Jay Schmelter, John P. McKearn, Ph.D. and the Reporting Person. RiverVest Partners IV, RiverVest Venture Partners IV, LLC and each of the individual managers (including the Reporting Person) share voting and dispositive power with regard to the Company's securities directly held by RiverVest Fund IV.</footnote>
        <footnote id="F3">The shares were purchased in the Issuer's initial public offering.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>/s/ Vineet R. Jindal, Attorney-in-Fact</signatureName>
        <signatureDate>2021-04-15</signatureDate>
    </ownerSignature>
</ownershipDocument>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
