<SEC-DOCUMENT>0001415889-24-024909.txt : 20241008
<SEC-HEADER>0001415889-24-024909.hdr.sgml : 20241008
<ACCEPTANCE-DATETIME>20241008191250
ACCESSION NUMBER:		0001415889-24-024909
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20241004
FILED AS OF DATE:		20241008
DATE AS OF CHANGE:		20241008

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Phillips Andrew John
		CENTRAL INDEX KEY:			0001921956
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-40315
		FILM NUMBER:		241361238

	MAIL ADDRESS:	
		STREET 1:		C/O CORMORANT ASSET MANAGEMENT, LLP
		STREET 2:		200 CLARENDON STREET, FL 52
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			OnKure Therapeutics, Inc.
		CENTRAL INDEX KEY:			0001637715
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		IRS NUMBER:				472309515
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		6707 WINCHESTER CIRCLE, SUITE 400
		CITY:			BOULDER
		STATE:			CO
		ZIP:			80301
		BUSINESS PHONE:		(720) 307-2892

	MAIL ADDRESS:	
		STREET 1:		6707 WINCHESTER CIRCLE, SUITE 400
		CITY:			BOULDER
		STATE:			CO
		ZIP:			80301

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Reneo Pharmaceuticals, Inc.
		DATE OF NAME CHANGE:	20150325
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>form3-10082024_111046.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2024-10-04</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001637715</issuerCik>
        <issuerName>OnKure Therapeutics, Inc.</issuerName>
        <issuerTradingSymbol>OKUR</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001921956</rptOwnerCik>
            <rptOwnerName>Phillips Andrew John</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O ONKURE THEREAPEUTICS, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>6707 WINCHESTER CIRCLE, SUITE 400</rptOwnerStreet2>
            <rptOwnerCity>BOULDER</rptOwnerCity>
            <rptOwnerState>CO</rptOwnerState>
            <rptOwnerZipCode>80301</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
            <isOfficer>false</isOfficer>
            <isTenPercentOwner>false</isTenPercentOwner>
            <isOther>false</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable></nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes></footnotes>

    <ownerSignature>
        <signatureName>/s/ Rogan Nunn, by power of attorney</signatureName>
        <signatureDate>2024-10-08</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-24
<SEQUENCE>2
<FILENAME>ex24-10082024_111048.htm
<TEXT>
<!DOCTYPE html PUBLIC "-//IETF//DTD HTML//EN">
<html><head><title>ex24-10082024_111048.htm</title></head><body style="margin-top:0;font-family:Times New Roman; font-size:10pt; color:#000000">
<p style="margin-top:16px; margin-bottom:0px; text-indent:48px; font-size:12pt"><b>LIMITED POWER OF ATTORNEY - SECURITIES LAW COMPLIANCE</b></p>
<p style="margin-top:32px; margin-bottom:0px; text-indent:48px; font-size:12pt" align="justify">The undersigned, as an officer or director of <b>OnKure Therapeutics, Inc. </b>(the <font style="font-family:Arial Unicode MS,Times New Roman">&ldquo;</font><b>Corporation</b><font style="font-family:Arial Unicode MS,Times New Roman">&rdquo;</font>),</p>
<p style="margin:0px; text-indent:48px; font-size:12pt" align="justify">hereby constitutes and appoints Jason Leverone and Rogan Nunn, each the undersigned<font style="font-family:Arial Unicode MS,Times New Roman">&rsquo;</font>s true and</p>
<p style="margin:0px; text-indent:48px; font-size:12pt" align="justify">lawful attorney-in-fact and agent to complete and execute such Forms 144, Form ID, Forms 3, 4</p>
<p style="margin:0px; text-indent:48px; font-size:12pt" align="justify">and5 and other forms as such attorney shall in his or her discretion determine to be required or</p>
<p style="margin:0px; text-indent:48px; font-size:12pt" align="justify">advisable pursuant to Rule 144 promulgated under the Securities Act of 1933, as amended, Section</p>
<p style="margin:0px; text-indent:48px; font-size:12pt" align="justify">16 of the Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated</p>
<p style="margin:0px; text-indent:48px; font-size:12pt" align="justify">thereunder, or any successor laws and regulations, as a consequence of the undersigned<font style="font-family:Arial Unicode MS,Times New Roman">&rsquo;</font>s ownership,</p>
<p style="margin:0px; text-indent:48px; font-size:12pt" align="justify">acquisition or disposition of securities of the Corporation, and to do all acts necessary in order to file</p>
<p style="margin:0px; text-indent:48px; font-size:12pt" align="justify">such forms with the Securities and Exchange Commission, any securities exchange or national</p>
<p style="margin:0px; text-indent:48px; font-size:12pt" align="justify">association, the Corporation and such other person or agency as the attorney shall deem appropriate.</p>
<p style="margin-top:16px; margin-bottom:0px; text-indent:48px; font-size:12pt" align="justify">The undersigned hereby ratifies and confirms all that said attorneys-in-fact and agents shall do or</p>
<p style="margin:0px; text-indent:48px; font-size:12pt" align="justify">cause to be done by virtue hereof. &nbsp;The undersigned acknowledges that the foregoing attorneys-in</p>
<p style="margin:0px; text-indent:48px; font-size:12pt" align="justify">fact, in serving in such capacity at the request of the undersigned, are not assuming, nor is the</p>
<p style="margin:0px; text-indent:48px; font-size:12pt" align="justify">Corporation assuming, any of the undersigned's responsibilities to comply with Section 16 of the</p>
<p style="margin:0px; text-indent:48px; font-size:12pt" align="justify">Securities Exchange Act of 1934, as amended.</p>
<p style="margin-top:16px; margin-bottom:0px; text-indent:48px; font-size:12pt" align="justify">This Limited Power of Attorney shall remain in full force and effect until the undersigned is no</p>
<p style="margin:0px; text-indent:48px; font-size:12pt" align="justify">longer required to file Form 144, and/or Forms 3, 4 and 5 with respect to the undersigned's holdings</p>
<p style="margin:0px; text-indent:48px; font-size:12pt" align="justify">of and transactions in securities issued by the Corporation unless earlier revoked by the undersigned</p>
<p style="margin:0px; text-indent:48px; font-size:12pt" align="justify">in a writing delivered to the foregoing attorneys-in-fact.</p>
<p style="margin-top:16px; margin-bottom:0px; text-indent:48px; font-size:12pt">This Limited Power of Attorney is executed as of the date set forth below.</p>
<p style="margin:0px"><br></p>
<p style="margin:0px"><br></p>
<p style="margin:0px; padding-left:336px; font-size:12pt">Signature: &nbsp;/s/ Andrew Phillips</p>
<p style="margin:0px"><br></p>
<p style="margin:0px; padding-left:336px; font-size:12pt">Print Name: &nbsp;Andrew Phillips</p>
<p style="margin-top:16px; margin-bottom:0px; text-indent:364.8px; font-size:12pt">Dated: &nbsp;September 11, 2024</p>
<p style="margin-top:16px; margin-bottom:0px"><br></p>
<p style="margin-top:16px; margin-bottom:0px"><br></p>
<p style="margin-top:16px; margin-bottom:0px"><br></p>
<p style="margin-top:16px; margin-bottom:0px"><br></p>
<p style="margin-top:16px; margin-bottom:0px"><br></p>
<p style="margin-top:16px; margin-bottom:0px"><br></p>
<p style="margin-top:16px; margin-bottom:0px"><br><br></p>
<p style="margin:0px; text-indent:326.667px; font-size:12pt">-0-</p>
<p style="margin:0px; text-indent:48px; font-size:7.5pt">C:\NRPortbl\palib2\JBM\9420504_1.docx<b style="font-size:12pt;font-weight:normal;"> </b>(1622)</p>
</body></html>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
