    <SEC-DOCUMENT>0000950170-25-036341-index.html : 20250310
    <SEC-HEADER>0000950170-25-036341.hdr.sgml : 20250310
    <ACCEPTANCE-DATETIME>20250310162520
    ACCESSION NUMBER:		0000950170-25-036341
    CONFORMED SUBMISSION TYPE:	424B3
    PUBLIC DOCUMENT COUNT:		9
    FILED AS OF DATE:		20250310
    DATE AS OF CHANGE:		20250310

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			OnKure Therapeutics, Inc.
    		CENTRAL INDEX KEY:			0001637715
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		ORGANIZATION NAME:           	03 Life Sciences
    		IRS NUMBER:				472309515
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		424B3
    		SEC ACT:		1933 Act
    		SEC FILE NUMBER:	333-282792
    		FILM NUMBER:		25724071

    	BUSINESS ADDRESS:
    		STREET 1:		6707 WINCHESTER CIRCLE, SUITE 400
    		CITY:			BOULDER
    		STATE:			CO
    		ZIP:			80301
    		BUSINESS PHONE:		(720) 307-2892

    	MAIL ADDRESS:
    		STREET 1:		6707 WINCHESTER CIRCLE, SUITE 400
    		CITY:			BOULDER
    		STATE:			CO
    		ZIP:			80301

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	Reneo Pharmaceuticals, Inc.
    		DATE OF NAME CHANGE:	20150325
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>424B3
    <SEQUENCE>1
    <FILENAME>424b3_okur_10-k_2024_202.htm
    <DESCRIPTION>424B3
    <TEXT>
    Document 1 - file: 424b3_okur_10-k_2024_202.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>2
    <FILENAME>img206454441_0.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 2 - file: img206454441_0.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>3
    <FILENAME>img206454441_1.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 3 - file: img206454441_1.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>4
    <FILENAME>img206454441_2.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 4 - file: img206454441_2.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>5
    <FILENAME>img206454441_3.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 5 - file: img206454441_3.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>6
    <FILENAME>img206454441_4.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 6 - file: img206454441_4.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>7
    <FILENAME>img206454441_5.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 7 - file: img206454441_5.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>8
    <FILENAME>img206454441_6.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 8 - file: img206454441_6.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>9
    <FILENAME>img206454441_7.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 9 - file: img206454441_7.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>