<DOCUMENT>
<TYPE>EX-4.25
<SEQUENCE>3
<FILENAME>ex4-25.txt
<DESCRIPTION>AMENDMENT TO LINE OF CREDIT AGREEMENT
<TEXT>
                                                                    Exhibit 4.25

                      AMENDMENT TO LINE OF CREDIT AGREEMENT

      AMENDMENT, dated July 30, 2001, (the "Amendment") by and between Milestone
Scientific Inc., a Delaware corporation, having its principal offices at 220
South Orange Avenue, Livingston, New Jersey 07039 (the "Company"), and K. Tucker
Andersen (the "Lender"), having an address c/o Cumberland Associates LLC, 1114
Avenue of the Americas, New York, NY 10036.

      For good and valuable consideration, the sufficiency of which is hereby
acknowledged, the undersigned hereby agree to the following amendments to the
Line of Credit Agreement, dated March 9, 2001, by and between the Company and
the Lender (the "Agreement"):

      A. The Agreement is hereby amended by striking Paragraph 1.4 thereof and
replacing said paragraph with the following new Paragraph 1.4:

            1.4 Upon the deposit of the Andersen Check in accordance with
      Paragraph 1.3, the Company shall have the right to withdraw from the
      Andersen Account such funds as from time to time may be needed by the
      Company in its discretion.

      B. The Agreement is hereby amended further by striking Paragraph 4.9
thereof and replacing said paragraph with the following new Paragraph 4.9:

            4.9 Use of Proceeds. Borrowings under Paragraph 1.4 of this
      Agreement will be used for general corporate purposes.

      C. Except as otherwise provided herein, the Agreement, the 10% Promissory
Note and Warrant issued thereunder, and the Registration Rights Agreement by and
between the Company and the Lender, dated March 9, 2001, shall continue
unchanged and in full force and effect.

            IN WITNESS WHEREOF, the undersigned have caused this Amendment to be
executed as of the date first above written.

                                             MILESTONE SCIENTIFIC INC.


                                                By: s/ Leonard Osser
                                                   -----------------------------
                                                Leonard Osser, Chairman and
                                                Chief Executive Officer


                                                s/ K. TUCKER ANDERSEN
                                                --------------------------------
                                                K. TUCKER ANDERSEN


                                       2

</TEXT>
</DOCUMENT>
