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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 zWBo2GPtdwOF0ID9m6MO7w==

<SEC-DOCUMENT>0001169232-03-006362.txt : 20031105
<SEC-HEADER>0001169232-03-006362.hdr.sgml : 20031105
<ACCEPTANCE-DATETIME>20031105100846
ACCESSION NUMBER:		0001169232-03-006362
CONFORMED SUBMISSION TYPE:	424B3
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20031105

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			MILESTONE SCIENTIFIC INC/NJ
		CENTRAL INDEX KEY:			0000855683
		STANDARD INDUSTRIAL CLASSIFICATION:	ORTHOPEDIC, PROSTHETIC & SURGICAL APPLIANCES & SUPPLIES [3842]
		IRS NUMBER:				133545623
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		424B3
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-54732
		FILM NUMBER:		03978031

	BUSINESS ADDRESS:	
		STREET 1:		220 S ORANGE AVE
		STREET 2:		LIVINGSTON CORPORATE PARK
		CITY:			LIVINGSTON
		STATE:			NJ
		ZIP:			07039
		BUSINESS PHONE:		2013793171

	MAIL ADDRESS:	
		STREET 1:		44 KEAN ROAD
		STREET 2:		220 SOUTH ORANGE AVE
		CITY:			LIVINGSTON
		STATE:			NJ
		ZIP:			07039

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	U S OPPORTUNITY SEARCH INC
		DATE OF NAME CHANGE:	19920703
</SEC-HEADER>
<DOCUMENT>
<TYPE>424B3
<SEQUENCE>1
<FILENAME>d57292_424b3.txt
<DESCRIPTION>PROSPECTUS SUPPLEMENT
<TEXT>

                                                          Rule 424(b)(3) and (c)
                                                   Commission File No. 333-54732

PROSPECTUS SUPPLEMENT

                           MILESTONE SCIENTIFIC INC.

                                2,275,000 shares
                                       of
                                  Common Stock

                                   ----------

      The following information supplements and amends the Prospectus of
Milestone Scientific Inc. ("Milestone") dated May 5, 2001, as amended in a
Post-Effective Amendment filed with the Securities and Exchange Commission on
September 16, 2003, relating to the issuance of 2,275,000 shares of Milestone's
common stock. This Supplement should be read in conjunction with that Prospectus
and Post-Effective Amendment.

      On October 3, 2003, Milestone issued its first drawdown notice to
Hillgreen Investment Limited ("Hillgreen"), under the Private Equity Line of
Credit Agreement delivered and effective on January 19, 2001, evidencing an
equity line agreement between Milestone and Hillgreen. This notice offered to
sell up to U.S. $200,000 in aggregate traded value of Milestone common shares to
Hillgreen under the pricing formula set forth in the equity line agreement,
during the two consecutive ten trading day pricing periods commencing on October
7, 2003 and ending on November 3, 2003 at no less than a traded value of U.S.
$1.05 per share. Pursuant to the calculation done at the end of the first
pricing period, Milestone issued 57,539 shares of common stock in consideration
for $100,000. Pursuant to the calculation done at the end of the second pricing
period, Milestone issued 44,290 shares of common stock to Hillgreen in
consideration for another $100,000 in this second part of the first drawdown.

           The date of this Prospectus Supplement is November 5, 2003

</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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