<DOCUMENT>
<TYPE>EX-32.1
<SEQUENCE>7
<FILENAME>d59203_ex32-1.txt
<DESCRIPTION>CERTIFICATION
<TEXT>

                                  Exhibit 32.1
                            CERTIFICATION PURSUANT TO
                             18 U.S.C. SECTION 1350,
                             AS ADOPTED PURSUANT TO

SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the Annual Report of Milestone Scientific, Inc. on Form
10-KSB for the year ending December 31, 2003 as filed with the Securities and
Exchange Commission on the date hereof (the "Report"), I, Leonard Osser, Chief
Executive Officer of the Company, certify pursuant to 18 U.S.C. ss. 1350, as
adopted pursuant to ss. 906 of the Sarbanes-Oxley Act of 2002, that: (1) The
Report fully complies with the requirements of section 13(a) or 15(d) of the
Securities Exchange Act of 1934; and (2) The information contained in the Report
fairly presents, in all material respects, the financial condition and result of
operations of the Company.


                                /s/ Leonard Osser
                                ----------------------
                                Leonard Osser
                                Chief Executive Officer
                                April 8, 2004

</TEXT>
</DOCUMENT>
