<DOCUMENT>
<TYPE>EX-32.2
<SEQUENCE>20
<FILENAME>d63238_ex32-2.txt
<DESCRIPTION>CERTIFICATION
<TEXT>

                                  Exhibit 32.2
                            CERTIFICATION PURSUANT TO
                             18 U.S.C. SECTION 1350,
                             AS ADOPTED PURSUANT TO

SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In  connection  with the Annual  Report of  Milestone  Scientific,  Inc. on Form
10-KSB for the year ending  December 31, 2004 as filed with the  Securities  and
Exchange  Commission  on the date hereof (the  "Report"),  I, Kevin T.  Lusardi,
Chief Financial Officer of Milestone, certify pursuant to 18 U.S.C. ss. 1350, as
adopted  pursuant to ss. 906 of the  Sarbanes-Oxley  Act of 2002,  that: (1) The
Report fully  complies  with the  requirements  of section 13(a) or 15(d) of the
Securities Exchange Act of 1934; and (2) The information contained in the Report
fairly presents, in all material respects, the financial condition and result of
operations of Milestone.


/s/ Kevin T. Lusardi
--------------------------
Kevin T. Lusardi
Chief Financial Officer
March 31, 2005


                                       46
</TEXT>
</DOCUMENT>
