<DOCUMENT>
<TYPE>EX-32.1
<SEQUENCE>6
<FILENAME>b412754ex32_1.txt
<DESCRIPTION>EXHIBIT 32.1
<TEXT>
<PAGE>


                                                                    Exhibit 32.1

                            CERTIFICATION PURSUANT TO
                             18 U.S.C. SECTION 1350,
                             AS ADOPTED PURSUANT TO


SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the Annual Report of Milestone Scientific Inc. on Form 10-KSB
for the year ending December 31, 2005 as filed with the Securities and Exchange
Commission on the date hereof (the "Report"), I, Leonard Osser, Chief Executive
Officer of Milestone, certify pursuant to 18 U.S.C. ss. 1350, as adopted
pursuant to ss. 906 of the Sarbanes-Oxley Act of 2002, that: (1) The Report
fully complies with the requirements of section 13(a) or 15(d) of the Securities
Exchange Act of 1934; and (2) The information contained in the Report fairly
presents, in all material respects, the financial condition and result of
operations of Milestone.









                              /s/ Leonard Osser
                              ----------------------
                              Leonard Osser
                              Chief Executive Officer
                              March 31, 2006

</TEXT>
</DOCUMENT>
