<DOCUMENT>
<TYPE>EX-32.1
<SEQUENCE>4
<FILENAME>b413325_ex32-1.txt
<DESCRIPTION>EXHIBIT 32.1
<TEXT>
<PAGE>


                                  EXHIBIT 32.1
                            CERTIFICATION PURSUANT TO
                             18 U.S.C. SECTION 1350,
                             AS ADOPTED PURSUANT TO

SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the Quarterly Report of Milestone Scientific Inc. on Form
10-QSB for the three months ending March 31, 2006 as filed with the Securities
and Exchange Commission on the date hereof (the "Report"), I, Leonard Osser,
Chief Executive Officer of Milestone, certify pursuant to 18 U.S.C. ss. 1350, as
adopted pursuant to ss. 906 of the Sarbanes-Oxley Act of 2002, that: (1) The
Report fully complies with the requirements of section 13(a) or 15(d) of the
Securities Exchange Act of 1934; and (2) The information contained in the Report
fairly presents, in all material respects, the financial condition and result of
operations of Milestone.


                                   /s/ Leonard Osser
                                   -------------------------------------
                                   Leonard Osser
                                   Chief Executive Officer
                                   May 15, 2006




</TEXT>
</DOCUMENT>
