<SEC-DOCUMENT>0000950123-10-117142.txt : 20110307
<SEC-HEADER>0000950123-10-117142.hdr.sgml : 20110307
<ACCEPTANCE-DATETIME>20101229141123
<PRIVATE-TO-PUBLIC>
ACCESSION NUMBER:		0000950123-10-117142
CONFORMED SUBMISSION TYPE:	CORRESP
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20101229

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			MILESTONE SCIENTIFIC INC.
		CENTRAL INDEX KEY:			0000855683
		STANDARD INDUSTRIAL CLASSIFICATION:	ORTHOPEDIC, PROSTHETIC & SURGICAL APPLIANCES & SUPPLIES [3842]
		IRS NUMBER:				133545623
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		CORRESP

	BUSINESS ADDRESS:	
		STREET 1:		45 KNIGHTSBRIDGE ROAD
		CITY:			PISCATAWAY
		STATE:			NJ
		ZIP:			08854
		BUSINESS PHONE:		(973) 535-2717

	MAIL ADDRESS:	
		STREET 1:		45 KNIGHTSBRIDGE ROAD
		CITY:			PISCATAWAY
		STATE:			NJ
		ZIP:			08854

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	MILESTONE SCIENTIFIC INC/NJ
		DATE OF NAME CHANGE:	19970409

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	U S OPPORTUNITY SEARCH INC
		DATE OF NAME CHANGE:	19920703
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<TYPE>CORRESP
<SEQUENCE>1
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<DIV align="left" style="font-size: 10pt; margin-top: 10pt; margin-left: 46%">Milestone Scientific Inc.<BR>
220 South Orange Avenue<BR>
Livingston, New Jersey 07039
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 10pt; margin-left: 46%">(973)&nbsp;535-2717
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 10pt">December&nbsp;29, 2010
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 10pt">Securities and Exchange Commission<BR>
Division of Corporate Finance<BR>
100 F Street NE<BR>
Washington, D.C. 20549

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    <TD align="left" valign="top">Attention:
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    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Mr. Kevin Kuhar<BR>
Staff Accountant</DIV></TD>
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    <TD align="left" valign="top"><B>Re:</B>
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    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px"><B>Milestone Scientific Inc. (the &#147;Company&#148;)<BR>
Form&nbsp;10-K for the Fiscal Year ended December&nbsp;31, 2009<BR>
Filed March&nbsp;10, 2010 (the &#147;Annual Report&#148;)<BR>
Definitive Proxy Statement filed April&nbsp;14, 2010<BR>
File No.&nbsp;001-14053 (the &#147;Proxy Statement&#148;)</B></DIV></TD>
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<DIV align="left" style="font-size: 10pt; margin-top: 10pt">Dear Mr.&nbsp;Kuhar:
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 10pt">This letter is in response to the Staff&#146;s supplemental comment letter dated December&nbsp;22, 2010
regarding the Annual Report and the Proxy Statement. Our response is keyed to the comment in the
letter. For the convenience of the Staff&#146;s review, we have set forth the comment contained in the
letter above each respective response.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 10pt">Your comment:
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 10pt"><U><B>Form&nbsp;10-K for the Fiscal Year Ended December&nbsp;31, 2009</B></U>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 10pt"><U><B>Item&nbsp;12. Security Ownership of Certain Beneficial Owners &#151; page 29</B></U>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 10pt"><B>1.&nbsp;We note your response to prior comment 3. Please tell us what authority you relied upon for
your decision to omit Mr.&nbsp;Martin from the table. With a view towards disclosure, please tell us
what Mr.&nbsp;Martin&#146;s holdings were and whether there was other information about Mr.&nbsp;Martin that was
not included in your filing, such as disclosure pursuant to Item&nbsp;404 of Regulation&nbsp;S-K. Also,
please explain in detail the &#147;opposite way transaction subject to Section&nbsp;</B><B>16(b)</B><B>&#148; you describe in
your response which appears to have occurred after his resignation.</B>
</DIV>
<P align="center" style="font-size: 10pt">&nbsp;

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<DIV align="left" style="font-size: 10pt; margin-top: 10pt">Our response:
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 10pt; text-indent: 4%">This shall confirm that there was no other information about Mr.&nbsp;Martin that was omitted from
the Annual Report and that we are not aware of any opposite way transaction, subject to Section
16(b), by Mr.&nbsp;Martin which occurred before or after his resignation.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 10pt; text-indent: 4%">Mr.&nbsp;Martin resigned from the Company effective March&nbsp;31, 2009. The number of shares
beneficially owned by Mr.&nbsp;Martin (322,357 shares, 2.17%) is based on his Statement of Changes In
Beneficial Ownership on Form&nbsp;4, filed on March&nbsp;3, 2009. His beneficial ownership percentage
includes shares underlying options held by him on March&nbsp;3, 2009 which were exercisable within 60
days from such date, namely options for 51,832 shares, exercisable at $0.45 per share. Subsequent
to his resignation, all of his options were cancelled prior to exercise.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 10pt; text-indent: 4%">In connection with our responses to the Staff comments set forth above, we acknowledge to you
that (i)&nbsp;the Company is responsible for the adequacy and accuracy of the disclosure in its filings
under the Securities Exchange Act, (ii)&nbsp;Staff comments or changes to disclosure in response to
Staff comments do not foreclose the Securities and Exchange Commission from taking any action with
respect to such filings, and (iii)&nbsp;the Company may not assert Staff comments as a defense in any
proceeding initiated by the Securities and Exchange Commission or any person under the federal
securities laws of the United States.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 10pt; text-indent: 4%">If you have any questions regarding the responses to your questions, please feel free to
contact me at 973-535-2717 or Stephen Zelnick of Morse, Zelnick, Rose and Lander, LLP, our
securities counsel, at 212-838-8040.
</DIV>

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    <TD valign="top" align="left">&nbsp;</TD>
    <TD colspan="3" align="left">Respectfully submitted</TD>
    <TD>&nbsp;</TD>
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    <TD valign="top">&nbsp;</TD>
    <TD colspan="3" style="border-bottom: 1px solid #000000" align="left">/s/ Joseph D&#146;Agostino
&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR>
<TR>
    <TD>&nbsp;</TD>
    <TD colspan="3" align="left">Joseph D&#146;Agostino&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR><TR>
    <TD>&nbsp;</TD>
    <TD colspan="3" align="left">Chief Financial Officer&nbsp;</TD>
    <TD>&nbsp;</TD>
</TR>
<TR>
    <TD colspan="5">&nbsp;</TD>
</TR>
</TABLE>

<DIV align="left" style="font-size: 10pt; margin-top: 10pt">cc: Stephen Zelnick
</DIV>



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</DIV>




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