<SEC-DOCUMENT>0001209191-14-036964.txt : 20140527
<SEC-HEADER>0001209191-14-036964.hdr.sgml : 20140526
<ACCEPTANCE-DATETIME>20140527142849
ACCESSION NUMBER:		0001209191-14-036964
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20131231
FILED AS OF DATE:		20140527
DATE AS OF CHANGE:		20140527

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			MILESTONE SCIENTIFIC INC.
		CENTRAL INDEX KEY:			0000855683
		STANDARD INDUSTRIAL CLASSIFICATION:	ORTHOPEDIC, PROSTHETIC & SURGICAL APPLIANCES & SUPPLIES [3842]
		IRS NUMBER:				133545623
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		220 SOUTH ORANGE AVENUE
		CITY:			LIVINGSTON
		STATE:			NJ
		ZIP:			07039
		BUSINESS PHONE:		(973) 535-2717

	MAIL ADDRESS:	
		STREET 1:		220 SOUTH ORANGE AVENUE
		CITY:			LIVINGSTON
		STATE:			NJ
		ZIP:			07039

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	MILESTONE SCIENTIFIC INC/NJ
		DATE OF NAME CHANGE:	19970409

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	U S OPPORTUNITY SEARCH INC
		DATE OF NAME CHANGE:	19920703

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			D'Agostino Joseph
		CENTRAL INDEX KEY:			0001425478

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-14053
		FILM NUMBER:		14869567

	MAIL ADDRESS:	
		STREET 1:		C/O MILESTONE SCIENTIFIC INC.
		STREET 2:		220 SOUTH ORANGE AVENUE
		CITY:			LIVINGSTON
		STATE:			NJ
		ZIP:			07039
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>doc4.xml
<DESCRIPTION>FORM 4 SUBMISSION
<TEXT>
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        <issuerName>MILESTONE SCIENTIFIC INC.</issuerName>
        <issuerTradingSymbol>MLSS</issuerTradingSymbol>
    </issuer>

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            <rptOwnerName>D'Agostino Joseph</rptOwnerName>
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            <rptOwnerStreet1>C/O MILESTONE SCIENTIFIC INC.</rptOwnerStreet1>
            <rptOwnerStreet2>220 SOUTH ORANGE AVENUE</rptOwnerStreet2>
            <rptOwnerCity>LIVINGSTON</rptOwnerCity>
            <rptOwnerState>NJ</rptOwnerState>
            <rptOwnerZipCode>07039</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
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            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>CFO &amp; COO</officerTitle>
        </reportingOwnerRelationship>
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                <underlyingSecurityShares>
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    <footnotes>
        <footnote id="F1">Shares to be issued at the termination of employment.</footnote>
        <footnote id="F2">Not applicable.</footnote>
        <footnote id="F3">377,108 shares of common stock to be issued at the termination of employment.  On May 9, 2014 all 377,108 of these shares of common stock were issued to the reporting person.</footnote>
        <footnote id="F4">Immediately.</footnote>
        <footnote id="F5">These options are exercisable as follows: (i) for 91,667 shares on the date of grant (12-31-11) and (ii) for an additional 1/3 of the 186,111 remaining shares on each of the 1st through 3rd anniversaries of the date of grant.</footnote>
        <footnote id="F6">These options are exercisable as follows: (i) for 1/3 on the date of grant (12-31-12); (ii) an additional 1/3 on the 1st anniversary of the date of grant; and (iii) an additional 1/3 on the second anniversary of the date of grant.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>/s/ Joseph D'Agostino</signatureName>
        <signatureDate>2014-05-27</signatureDate>
    </ownerSignature>
</ownershipDocument>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
