<SEC-DOCUMENT>0000899243-16-023911.txt : 20160630
<SEC-HEADER>0000899243-16-023911.hdr.sgml : 20160630
<ACCEPTANCE-DATETIME>20160630163027
ACCESSION NUMBER:		0000899243-16-023911
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20160629
FILED AS OF DATE:		20160630
DATE AS OF CHANGE:		20160630

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			MILESTONE SCIENTIFIC INC.
		CENTRAL INDEX KEY:			0000855683
		STANDARD INDUSTRIAL CLASSIFICATION:	ORTHOPEDIC, PROSTHETIC & SURGICAL APPLIANCES & SUPPLIES [3842]
		IRS NUMBER:				133545623
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		220 SOUTH ORANGE AVENUE
		CITY:			LIVINGSTON
		STATE:			NJ
		ZIP:			07039
		BUSINESS PHONE:		(973) 535-2717

	MAIL ADDRESS:	
		STREET 1:		220 SOUTH ORANGE AVENUE
		CITY:			LIVINGSTON
		STATE:			NJ
		ZIP:			07039

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	MILESTONE SCIENTIFIC INC/NJ
		DATE OF NAME CHANGE:	19970409

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	U S OPPORTUNITY SEARCH INC
		DATE OF NAME CHANGE:	19920703

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Innovest SpA
		CENTRAL INDEX KEY:			0001608420
		STATE OF INCORPORATION:			L6
		FISCAL YEAR END:			0131

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-14053
		FILM NUMBER:		161743468

	BUSINESS ADDRESS:	
		STREET 1:		CORSO VENEZIA 44
		CITY:			MILAN
		STATE:			L6
		ZIP:			20121
		BUSINESS PHONE:		390223164798

	MAIL ADDRESS:	
		STREET 1:		CORSO VENEZIA 44
		CITY:			MILAN
		STATE:			L6
		ZIP:			20121

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			BP4 S.r.l.
		CENTRAL INDEX KEY:			0001606683
		STATE OF INCORPORATION:			L6
		FISCAL YEAR END:			0131

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-14053
		FILM NUMBER:		161743469

	BUSINESS ADDRESS:	
		STREET 1:		CORSO VENEZIA 44
		CITY:			MILAN
		STATE:			L6
		ZIP:			20121
		BUSINESS PHONE:		39-02-231-64-798

	MAIL ADDRESS:	
		STREET 1:		CORSO VENEZIA 44
		CITY:			MILAN
		STATE:			L6
		ZIP:			20121

	FORMER NAME:	
		FORMER CONFORMED NAME:	BP4 S.p.A.
		DATE OF NAME CHANGE:	20160616

	FORMER NAME:	
		FORMER CONFORMED NAME:	BP4 S.r.l.
		DATE OF NAME CHANGE:	20140523

	FORMER NAME:	
		FORMER CONFORMED NAME:	BP4 SpA
		DATE OF NAME CHANGE:	20140428
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>doc4.xml
<DESCRIPTION>FORM 4 SUBMISSION
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2016-06-29</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000855683</issuerCik>
        <issuerName>MILESTONE SCIENTIFIC INC.</issuerName>
        <issuerTradingSymbol>MLSS</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001606683</rptOwnerCik>
            <rptOwnerName>BP4 S.r.l.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>CORSO VENEZIA 44</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>MILAN</rptOwnerCity>
            <rptOwnerState>L6</rptOwnerState>
            <rptOwnerZipCode>20121</rptOwnerZipCode>
            <rptOwnerStateDescription>ITALY</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>See Remarks</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001608420</rptOwnerCik>
            <rptOwnerName>Innovest SpA</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>CORSO VENEZIA 44</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>MILAN</rptOwnerCity>
            <rptOwnerState>L6</rptOwnerState>
            <rptOwnerZipCode>20121</rptOwnerZipCode>
            <rptOwnerStateDescription>ITALY</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>See Remarks</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock, Par Value $0.001 Per Share</value>
                <footnoteId id="F1"/>
            </securityTitle>
            <transactionDate>
                <value>2016-06-29</value>
                <footnoteId id="F2"/>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>1000000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>2.00</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>3000000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">These shares are held directly by BP4 S.r.l.  Innovest S.p.A. is the controlling shareholder of BP4 S.r.l. and may be deemed to have sole voting and investment power over the securities held by BP4 S.r.l.</footnote>
        <footnote id="F2">BP4 S.r.l. made payment in two tranches.  The full payment was received on June 22, 2016 and the shares were issued on June 29, 2016.</footnote>
    </footnotes>

    <remarks>Affiliate of President &amp; CEO of Dental Division</remarks>

    <ownerSignature>
        <signatureName>BP4 S.r.l., By: /s/ Giandomenico Trombetta, Director</signatureName>
        <signatureDate>2016-06-30</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Innovest S.p.A., By: /s/ Giandomenico Trombetta, Director</signatureName>
        <signatureDate>2016-06-30</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
