<SEC-DOCUMENT>0001193125-16-556595-index.html : 20160602
<SEC-HEADER>0001193125-16-556595.hdr.sgml : 20160602

<ACCEPTANCE-DATETIME>20160426165104

<PRIVATE-TO-PUBLIC>

ACCESSION NUMBER:		0001193125-16-556595

CONFORMED SUBMISSION TYPE:	S-3/A

PUBLIC DOCUMENT COUNT:		5

FILED AS OF DATE:		20160426

DATE AS OF CHANGE:		20160504


FILER:


	COMPANY DATA:	

		COMPANY CONFORMED NAME:			MILESTONE SCIENTIFIC INC.

		CENTRAL INDEX KEY:			0000855683

		STANDARD INDUSTRIAL CLASSIFICATION:	ORTHOPEDIC, PROSTHETIC & SURGICAL APPLIANCES & SUPPLIES [3842]

		IRS NUMBER:				133545623

		STATE OF INCORPORATION:			DE

		FISCAL YEAR END:			1231



	FILING VALUES:

		FORM TYPE:		S-3/A

		SEC ACT:		1933 Act

		SEC FILE NUMBER:	333-209466

		FILM NUMBER:		161592519



	BUSINESS ADDRESS:	

		STREET 1:		220 SOUTH ORANGE AVENUE

		CITY:			LIVINGSTON

		STATE:			NJ

		ZIP:			07039

		BUSINESS PHONE:		(973) 535-2717



	MAIL ADDRESS:	

		STREET 1:		220 SOUTH ORANGE AVENUE

		CITY:			LIVINGSTON

		STATE:			NJ

		ZIP:			07039



	FORMER COMPANY:	

		FORMER CONFORMED NAME:	MILESTONE SCIENTIFIC INC/NJ

		DATE OF NAME CHANGE:	19970409



	FORMER COMPANY:	

		FORMER CONFORMED NAME:	U S OPPORTUNITY SEARCH INC

		DATE OF NAME CHANGE:	19920703



</SEC-HEADER>

<DOCUMENT>
<TYPE>S-3/A
<SEQUENCE>1
<FILENAME>d127070ds3a.htm
<DESCRIPTION>AMENDMENT NO. 1 TO FORM S-3
<TEXT>
Document 1 - file: d127070ds3a.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-4.5
<SEQUENCE>2
<FILENAME>d127070dex45.htm
<DESCRIPTION>EX-4.5
<TEXT>
Document 2 - file: d127070dex45.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>3
<FILENAME>d127070dex51.htm
<DESCRIPTION>EX-5.1
<TEXT>
Document 3 - file: d127070dex51.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>4
<FILENAME>d127070dex231.htm
<DESCRIPTION>EX-23.1
<TEXT>
Document 4 - file: d127070dex231.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>COVER
<SEQUENCE>5
<FILENAME>filename5.htm
<TEXT>
Document 5 - file: filename5.htm

</DOCUMENT>
</SEC-DOCUMENT>