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v3.8.0.1

Note R - Commitments and Other (Details Textual) |  |  | 1 Months Ended | 12 Months Ended
--- | --- | --- | --- | ---
Oct. 02, 2017 USD ($) $ / shares shares | Jan. 01, 2005 shares | Mar. 31, 2018 USD ($) | Feb. 28, 2018 USD ($) | Dec. 31, 2017 USD ($) ft² | Dec. 31, 2016 USD ($)
Area of Office Space | ft² |  |  |  |  | 7,625 |
Operating Leases, Rent Expense, Minimum Rentals |  |  |  |  | $ 12,522 |
Operating Leases, Rent Expense |  |  |  |  | 141,428 | $ 133,657
Payments for Postemployment Benefits |  |  |  |  | $ 203,111 | 203,111
Define Benefit Plan, Payment Period |  |  |  |  | 5 years |
Additional Percentage of Director Compensation on Sales Value Using Certain Specify Technology |  | 2.50% |  |  |  |
Additional Percentage of Director Compensation Sales Value Using Other Kind of Technology |  | 5.00% |  |  |  |
Consulting Services [Member] |  |  |  |  |  |
Related Party Transaction, Expenses from Transactions with Related Party |  |  |  |  | $ 100,000 | 100,000
Innovest S.p.A. [Member] | Consulting Services [Member] |  |  |  |  |  |
Related Party Transaction, Expenses from Transactions with Related Party |  |  |  |  | 80,000 |
Director of Clinical Affairs [Member] |  |  |  |  |  |
Stock Issued During Period, Shares, Stock Options Exercised, Attributable to Consultants | shares |  | 8,333 |  |  |  |
Royalty Expense |  |  |  |  | 554,150 | 526,737
Professional Fees |  |  |  |  | $ 275,000 | $ 275,000
Former CEO [Member] |  |  |  |  |  |
Employee Resignation Assertion, Basic Salary for One Year | $ 300,000 |  |  |  |  |
Employee Resignation Assertion, Health and Disability Insurance for One Year | 30,000 |  |  |  |  |
Employee Resignation Assertion, Car Allowance for One Year | $ 1,200 |  |  |  |  |
Employee Resignation Assertion, Vesting Term After Resignation | 90 days |  |  |  |  |
Employee Resignation Assertion, Number of Options Vested | shares | 921,942 |  |  |  |  |
Employee Resignation Assertion, Options Exercise Price | $ / shares | $ 2 |  |  |  |  |
Former CEO [Member] | Subsequent Event [Member] |  |  |  |  |  |
Employee Resignation Assertion, Gross Settlement |  |  |  | $ 175,000 |  |
Employee Resignation Assertion, Payment |  |  | $ 75,000 |  |  |

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