    <SEC-DOCUMENT>0001437749-18-008064-index.html : 20180430
    <SEC-HEADER>0001437749-18-008064.hdr.sgml : 20180430
    <ACCEPTANCE-DATETIME>20180430111706
    ACCESSION NUMBER:		0001437749-18-008064
    CONFORMED SUBMISSION TYPE:	DEF 14A
    PUBLIC DOCUMENT COUNT:		5
    CONFORMED PERIOD OF REPORT:	20180530
    FILED AS OF DATE:		20180430
    DATE AS OF CHANGE:		20180430
    EFFECTIVENESS DATE:		20180430

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			MILESTONE SCIENTIFIC INC.
    		CENTRAL INDEX KEY:			0000855683
    		STANDARD INDUSTRIAL CLASSIFICATION:	ORTHOPEDIC, PROSTHETIC & SURGICAL APPLIANCES & SUPPLIES [3842]
    		IRS NUMBER:				133545623
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		DEF 14A
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-14053
    		FILM NUMBER:		18787579

    	BUSINESS ADDRESS:
    		STREET 1:		220 SOUTH ORANGE AVENUE
    		CITY:			LIVINGSTON
    		STATE:			NJ
    		ZIP:			07039
    		BUSINESS PHONE:		(973) 535-2717

    	MAIL ADDRESS:
    		STREET 1:		220 SOUTH ORANGE AVENUE
    		CITY:			LIVINGSTON
    		STATE:			NJ
    		ZIP:			07039

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	MILESTONE SCIENTIFIC INC/NJ
    		DATE OF NAME CHANGE:	19970409

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	U S OPPORTUNITY SEARCH INC
    		DATE OF NAME CHANGE:	19920703
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>DEF 14A
    <SEQUENCE>1
    <FILENAME>mlss20180412_def14a.htm
    <DESCRIPTION>FORM DEF 14A
    <TEXT>
    Document 1 - file: mlss20180412_def14a.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>2
    <FILENAME>card4.jpg
    <TEXT>
    Document 2 - file: card4.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>3
    <FILENAME>card3.jpg
    <TEXT>
    Document 3 - file: card3.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>4
    <FILENAME>card2.jpg
    <TEXT>
    Document 4 - file: card2.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>5
    <FILENAME>card.jpg
    <TEXT>
    Document 5 - file: card.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>