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Note 9 - Stockholders' Equity - Summary of Option Activity for Employees and Non-employees (Details) - Share-based Payment Arrangement, Option [Member] - USD ($) | 3 Months Ended | 12 Months Ended
--- | --- | ---
Mar. 31, 2021 | Mar. 31, 2020 | Dec. 31, 2020 | Dec. 31, 2019
Share-based Payment Arrangement, Employee [Member] |  |  |  |
Number of options (in shares) | 1,953,443 | 1,212,442 | 1,212,442 |
Weighted average exercise price, outstanding (in dollars per share) | $ 1.88 | $ 1.71 | $ 1.71 |
Weighted average remaining contractual life, outstanding (Year) | 3 years 226 days | 2 years 146 days | 3 years 32 days | 2 years 146 days
Aggregate intrinsic value, outstanding | $ 2,457,153 |  | $ 476,964 |
Number of options granted (in shares) | 32,175 |  |  |
Weighted average exercise price, granted (in dollars per share) | $ 3.11 |  |  |
Weighted average remaining contractual life, granted (Year) |  |  |  |
Aggregate intrinsic value, granted |  |  |  |
Number of options exercised (in shares) |  |  |  |
Weighted average exercise price, exercised (in dollars per share) |  |  |  |
Weighted average remaining contractual life, exercised (Year) |  |  |  |
Aggregate intrinsic value, exercised |  |  |  |
Number of options forfeited and expired (in shares) | (435,558) |  |  |
Weighted average exercise price, forfeited or expired (in dollars per share) | $ 1.58 |  |  |
Number of options exercisable (in shares) | 745,045 | 1,117,829 |  |
Weighted average exercise price, exercisable (in dollars per share) | $ 1.93 | $ 1.84 |  |
Weighted average remaining contractual life, exercisable (Year) | 2 years 219 days | 1 year 306 days |  |
Aggregate intrinsic value, exercisable | $ 1,222,127 |  |  |
Number of options (in shares) | 1,550,060 | 1,212,442 | 1,953,443 | 1,212,442
Weighted average exercise price, outstanding (in dollars per share) | $ 1.98 | $ 1.71 | $ 1.88 | $ 1.71
Number of options exercised (in shares) |  |  |  |
Share-based Payment Arrangement, Nonemployee [Member] |  |  |  |
Number of options (in shares) | 74,997 | 49,998 | 49,998 |
Weighted average exercise price, outstanding (in dollars per share) | $ 1.41 | $ 1.87 | $ 1.87 |
Weighted average remaining contractual life, outstanding (Year) | 3 years 109 days | 2 years 343 days | 3 years 65 days | 2 years 343 days
Aggregate intrinsic value, outstanding | $ 161,660 |  | $ 54,748 |
Number of options granted (in shares) | 16,666 | 8,333 |  |
Weighted average exercise price, granted (in dollars per share) | $ 4.30 | $ 1.65 |  |
Weighted average remaining contractual life, granted (Year) |  |  |  |
Aggregate intrinsic value, granted |  |  |  |
Number of options exercised (in shares) |  |  |  |
Weighted average exercise price, exercised (in dollars per share) |  |  |  |
Number of options exercisable (in shares) | 52,769 | 41,663 |  |
Weighted average exercise price, exercisable (in dollars per share) | $ 1.34 | $ 1.71 |  |
Weighted average remaining contractual life, exercisable (Year) | 2 years 135 days | 2 years 10 days |  |
Aggregate intrinsic value, exercisable | $ 117,829 | $ 84,579 |  |
Number of options (in shares) | 91,663 | 58,331 | 74,997 | 49,998
Weighted average exercise price, outstanding (in dollars per share) | $ 1.87 | $ 1.87 | $ 1.41 | $ 1.87
Number of options exercised (in shares) |  |  |  |

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- Definition Weighted average remaining contractual term for option awards exercised, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. + References No definition available. + Details
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- Definition The number of shares into which fully or partially vested stock options outstanding as of the balance sheet date can be currently converted under the option plan. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1)(iii) -URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901 + Details
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- Definition The weighted-average price as of the balance sheet date at which grantees can acquire the shares reserved for issuance on vested portions of options outstanding and currently exercisable under the stock option plan. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1)(iii) -URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901 + Details
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- Definition For presentations that combine terminations, the number of shares under options that were cancelled during the reporting period as a result of occurrence of a terminating event specified in contractual agreements pertaining to the stock option plan or that expired. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1)(iv)(3)-(4) -URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901 + Details
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