<SEC-DOCUMENT>0001437749-23-028403.txt : 20231017
<SEC-HEADER>0001437749-23-028403.hdr.sgml : 20231017
<ACCEPTANCE-DATETIME>20231017160304
ACCESSION NUMBER:		0001437749-23-028403
CONFORMED SUBMISSION TYPE:	144
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20231017
DATE AS OF CHANGE:		20231017

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			MILESTONE SCIENTIFIC INC.
		CENTRAL INDEX KEY:			0000855683
		STANDARD INDUSTRIAL CLASSIFICATION:	ORTHOPEDIC, PROSTHETIC & SURGICAL APPLIANCES & SUPPLIES [3842]
		IRS NUMBER:				133545623
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		144
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	001-14053
		FILM NUMBER:		231329632

	BUSINESS ADDRESS:	
		STREET 1:		220 SOUTH ORANGE AVENUE
		CITY:			LIVINGSTON
		STATE:			NJ
		ZIP:			07039
		BUSINESS PHONE:		(973) 535-2717

	MAIL ADDRESS:	
		STREET 1:		220 SOUTH ORANGE AVENUE
		CITY:			LIVINGSTON
		STATE:			NJ
		ZIP:			07039

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	MILESTONE SCIENTIFIC INC/NJ
		DATE OF NAME CHANGE:	19970409

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	U S OPPORTUNITY SEARCH INC
		DATE OF NAME CHANGE:	19920703

REPORTING-OWNER:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Trombetta Giandomenico
		CENTRAL INDEX KEY:			0001606650

	FILING VALUES:
		FORM TYPE:		144

	MAIL ADDRESS:	
		STREET 1:		CORSO VENEZIA 44
		CITY:			MILAN
		STATE:			L6
		ZIP:			20121
</SEC-HEADER>
<DOCUMENT>
<TYPE>144
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
<headerData>
<submissionType>144</submissionType>
<filerInfo>
<filer>
<filerCredentials>
<cik>0001606650</cik>
<ccc>XXXXXXXX</ccc>
</filerCredentials>
</filer>
<liveTestFlag>LIVE</liveTestFlag>


</filerInfo>
</headerData>
<formData>
<issuerInfo>
<issuerCik>0000855683</issuerCik>
<issuerName>Milestone Scientific Inc.</issuerName>
<secFileNumber>001-14053</secFileNumber>
      <issuerAddress>
<com:street1>425 Eagle Rock Avenue Suite 403</com:street1>
<com:city>Roseland</com:city>
<com:stateOrCountry>NJ</com:stateOrCountry>
<com:zipCode>07068</com:zipCode>
</issuerAddress>
<issuerContactPhone>973-535-2717</issuerContactPhone>
<nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Trombetta Gian Domenico</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
<relationshipsToIssuer>
<relationshipToIssuer>Director</relationshipToIssuer>
</relationshipsToIssuer>
</issuerInfo>
<securitiesInformation>
<securitiesClassTitle>Common</securitiesClassTitle>
<brokerOrMarketmakerDetails>
<name>Intesa San Paolo SPA</name>
<address>
<com:street1>Corso Venezia</com:street1>
<com:city>20121 Milan (Italy)</com:city>
<com:stateOrCountry>L6</com:stateOrCountry>
<com:zipCode>0000</com:zipCode>
</address>
</brokerOrMarketmakerDetails>
<noOfUnitsSold>100000</noOfUnitsSold>
<aggregateMarketValue>90000.00</aggregateMarketValue>
<noOfUnitsOutstanding>71365659</noOfUnitsOutstanding>
<approxSaleDate>10/24/2023</approxSaleDate>
<securitiesExchangeName>NYSE</securitiesExchangeName>
</securitiesInformation>
<securitiesToBeSold>
<securitiesClassTitle>Common</securitiesClassTitle>
<acquiredDate>05/14/2014</acquiredDate>
<natureOfAcquisitionTransaction>Private Placement Purchase</natureOfAcquisitionTransaction>
<nameOfPersonfromWhomAcquired>Milestone Scientific Inc.</nameOfPersonfromWhomAcquired>
<isGiftTransaction>N</isGiftTransaction>
<amountOfSecuritiesAcquired>2000000</amountOfSecuritiesAcquired>
<paymentDate>05/12/2014</paymentDate>
<natureOfPayment>Cash</natureOfPayment>
</securitiesToBeSold>
<nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
<noticeSignature>
<noticeDate>10/17/2023</noticeDate>
<signature>/s/ Gian Domenico Trombetta</signature>
</noticeSignature>
</formData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
