<SEC-DOCUMENT>0001437749-25-028695.txt : 20250909
<SEC-HEADER>0001437749-25-028695.hdr.sgml : 20250909
<ACCEPTANCE-DATETIME>20250909163300
ACCESSION NUMBER:		0001437749-25-028695
CONFORMED SUBMISSION TYPE:	144
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20250909
DATE AS OF CHANGE:		20250909

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			MILESTONE SCIENTIFIC INC.
		CENTRAL INDEX KEY:			0000855683
		STANDARD INDUSTRIAL CLASSIFICATION:	ORTHOPEDIC, PROSTHETIC & SURGICAL APPLIANCES & SUPPLIES [3842]
		ORGANIZATION NAME:           	08 Industrial Applications and Services
		EIN:				133545623
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		144
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	001-14053
		FILM NUMBER:		251303677

	BUSINESS ADDRESS:	
		STREET 1:		220 SOUTH ORANGE AVENUE
		CITY:			LIVINGSTON
		STATE:			NJ
		ZIP:			07039
		BUSINESS PHONE:		(973) 535-2717

	MAIL ADDRESS:	
		STREET 1:		220 SOUTH ORANGE AVENUE
		CITY:			LIVINGSTON
		STATE:			NJ
		ZIP:			07039

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	MILESTONE SCIENTIFIC INC/NJ
		DATE OF NAME CHANGE:	19970409

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	U S OPPORTUNITY SEARCH INC
		DATE OF NAME CHANGE:	19920703

REPORTING-OWNER:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BP4 S.r.l.
		CENTRAL INDEX KEY:			0001606683
		ORGANIZATION NAME:           	
		EIN:				000000000
		STATE OF INCORPORATION:			L6
		FISCAL YEAR END:			0131

	FILING VALUES:
		FORM TYPE:		144

	BUSINESS ADDRESS:	
		STREET 1:		CORSO VENEZIA 44
		CITY:			MILAN
		STATE:			L6
		ZIP:			20121
		BUSINESS PHONE:		39-02-231-64-798

	MAIL ADDRESS:	
		STREET 1:		CORSO VENEZIA 44
		CITY:			MILAN
		STATE:			L6
		ZIP:			20121

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	BP4 S.p.A.
		DATE OF NAME CHANGE:	20160616

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	BP4 S.r.l.
		DATE OF NAME CHANGE:	20140523

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	BP4 SpA
		DATE OF NAME CHANGE:	20140428
</SEC-HEADER>
<DOCUMENT>
<TYPE>144
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
<headerData>
<submissionType>144</submissionType>
<filerInfo>
<filer>
<filerCredentials>
<cik>0001606683</cik>
<ccc>XXXXXXXX</ccc>
</filerCredentials>
</filer>
<liveTestFlag>LIVE</liveTestFlag>


</filerInfo>
</headerData>
<formData>
<issuerInfo>
<issuerCik>0000855683</issuerCik>
<issuerName>Milestone Scientific Inc.</issuerName>
<secFileNumber>001-14053</secFileNumber>
<issuerAddress>
<com:street1>425 Eagle Rock Avenue Suite 403</com:street1>
<com:city>Roseland</com:city>
<com:stateOrCountry>NJ</com:stateOrCountry>
<com:zipCode>07068</com:zipCode>
</issuerAddress>
<issuerContactPhone>973-535-2717</issuerContactPhone>
<nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>BP4 S.r.l.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
<relationshipsToIssuer>
<relationshipToIssuer>10% Stockholder</relationshipToIssuer>
</relationshipsToIssuer>
</issuerInfo>
<securitiesInformation>
<securitiesClassTitle>Common Stock</securitiesClassTitle>
<brokerOrMarketmakerDetails>
<name>Intesa San Paolo SPA</name>
<address>
<com:street1>Corso Venezia</com:street1>
<com:city>Milan</com:city>
<com:stateOrCountry>L6</com:stateOrCountry>
<com:zipCode>20121</com:zipCode>
</address>
</brokerOrMarketmakerDetails>
<noOfUnitsSold>400000</noOfUnitsSold>
<aggregateMarketValue>236000.00</aggregateMarketValue>
<noOfUnitsOutstanding>78559147</noOfUnitsOutstanding>
<approxSaleDate>09/10/2025</approxSaleDate>
<securitiesExchangeName>NYSE</securitiesExchangeName>
</securitiesInformation>
<securitiesToBeSold>
<securitiesClassTitle>Common Stock</securitiesClassTitle>
<acquiredDate>05/14/2014</acquiredDate>
<natureOfAcquisitionTransaction>Private Placement Purchase</natureOfAcquisitionTransaction>
<nameOfPersonfromWhomAcquired>Milestone Scientific Inc.</nameOfPersonfromWhomAcquired>
<isGiftTransaction>N</isGiftTransaction>
<amountOfSecuritiesAcquired>2000000</amountOfSecuritiesAcquired>
<paymentDate>05/12/2014</paymentDate>
<natureOfPayment>Cash</natureOfPayment>
</securitiesToBeSold>
<nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
<securitiesSoldInPast3Months>
<sellerDetails>
<name>BP4 Srl</name>
<address>
<com:street1>corso venezia 44</com:street1>
<com:city>Milan</com:city>
<com:stateOrCountry>L6</com:stateOrCountry>
<com:zipCode>20121</com:zipCode>
</address>
</sellerDetails>
<securitiesClassTitle>Milestone Scientific Inc common stock</securitiesClassTitle>
<saleDate>06/02/2025</saleDate>
<amountOfSecuritiesSold>375485</amountOfSecuritiesSold>
<grossProceeds>301082.00</grossProceeds>
</securitiesSoldInPast3Months>
<noticeSignature>
<noticeDate>09/09/2025</noticeDate>
<signature>/s/ Pedro Paluo</signature>
</noticeSignature>
</formData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
