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Purdue Collaboration (Details) $ in Thousands |  | 3 Months Ended |
--- | --- | --- | ---
Dec. 02, 2016 USD ($) target | Mar. 31, 2018 USD ($) | Mar. 31, 2017 USD ($) | Dec. 31, 2017 USD ($)
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Current portion of deferred revenue |  | $ 0 |  | $ 1,034
Collaboration revenue |  | $ 36 | $ 2,432 |
Reimbursable research and development activities |  |  | $ 363 |
Purdue Collaboration |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Number of additional collaboration targets | target | 3 |  |  |
Non-refundable upfront payment received for research agreement | $ 10,000 |  |  |
Potential milestone revenue | 776,500 |  |  |
Aggregate research milestone revenue | 16,500 |  |  |
Aggregate regulatory milestone revenue | 410,000 |  |  |
Aggregate commercial milestone revenue | $ 350,000 |  |  |
Maximum | Purdue Collaboration |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Commercial sales royalty, percent | 10.00% |  |  |

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