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Purdue Collaboration (Details) $ in Thousands		3 Months Ended
	Dec. 02, 2016 USD ($) target	Mar. 31, 2018 USD ($)	Mar. 31, 2017 USD ($)	Dec. 31, 2017 USD ($)
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Current portion of deferred revenue		$ 0		$ 1,034
Collaboration revenue		$ 36	$ 2,432
Reimbursable research and development activities			$ 363
Purdue Collaboration
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Number of additional collaboration targets | target	3
Non-refundable upfront payment received for research agreement	$ 10,000
Potential milestone revenue	776,500
Aggregate research milestone revenue	16,500
Aggregate regulatory milestone revenue	410,000
Aggregate commercial milestone revenue	$ 350,000
Maximum | Purdue Collaboration
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Commercial sales royalty, percent	10.00%

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