<SEC-DOCUMENT>0000905718-22-000423.txt : 20220225
<SEC-HEADER>0000905718-22-000423.hdr.sgml : 20220225
<ACCEPTANCE-DATETIME>20220225161557
ACCESSION NUMBER:		0000905718-22-000423
CONFORMED SUBMISSION TYPE:	SC 13D/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20220225
DATE AS OF CHANGE:		20220225
GROUP MEMBERS:		ABINGWORTH BIOVENTURES VII, LP

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			EXICURE, INC.
		CENTRAL INDEX KEY:			0001698530
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				815333008
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-90023
		FILM NUMBER:		22680178

	BUSINESS ADDRESS:	
		STREET 1:		2430 N. HALSTED ST.
		CITY:			CHICAGO
		STATE:			IL
		ZIP:			60614
		BUSINESS PHONE:		847-673-1700

	MAIL ADDRESS:	
		STREET 1:		2430 N. HALSTED ST.
		CITY:			CHICAGO
		STATE:			IL
		ZIP:			60614

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Max-1 Acquisition Corp
		DATE OF NAME CHANGE:	20170221

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Abingworth LLP
		CENTRAL INDEX KEY:			0001397144
		IRS NUMBER:				980518585
		STATE OF INCORPORATION:			X0
		FISCAL YEAR END:			0630

	FILING VALUES:
		FORM TYPE:		SC 13D/A

	BUSINESS ADDRESS:	
		STREET 1:		38 JERMYN STREET
		CITY:			LONDON
		STATE:			X0
		ZIP:			SW1Y 6DN
		BUSINESS PHONE:		44 (0)20 7534 1500

	MAIL ADDRESS:	
		STREET 1:		38 JERMYN STREET
		CITY:			LONDON
		STATE:			X0
		ZIP:			SW1Y 6DN
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13D/A
<SEQUENCE>1
<FILENAME>exicure_13dadec162021.htm
<DESCRIPTION>SC 13D/A
<TEXT>
<HTML>
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<TITLE></TITLE>
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<P STYLE="font: 11pt/18pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>UNITED STATES</B></P>

<P STYLE="font: 11pt/18pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B></P>

<P STYLE="font: 11pt/18pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Washington, D.C. 20549</B></P>

<P STYLE="font: 11pt/18pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>SCHEDULE 13D</B></P>

<P STYLE="font: 11pt/18pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Under the Securities Exchange Act of 1934</B></P>

<P STYLE="font: 11pt/18pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>(Amendment No. 1)</B></P>

<P STYLE="font: 11pt/18pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 100%; border-bottom: black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding: 0.25pt 5.65pt 0.5pt; text-align: center"><FONT STYLE="font-size: 11pt">Exicure, Inc. </FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.25pt 5.65pt 12.25pt; font: 12pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font-size: 11pt">(Name of Issuer)</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding: 0.25pt 5.65pt 0.5pt; text-align: center"><FONT STYLE="font-size: 11pt">Common Stock, par value $0.0001 per share </FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.25pt 5.65pt 12.25pt; font: 12pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font-size: 11pt">(Title of Class of Securities)</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.25pt 5.65pt; font: 12pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font-size: 11pt">30205M101</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-top: black 1pt solid; border-bottom: black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding: 0.5pt 5.65pt 12.5pt; text-align: center"><FONT STYLE="font-size: 11pt">(CUSIP Number)</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">
    <P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-align: center">John Heard</P>
    <P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-align: center">Abingworth LLP</P>
    <P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-align: center">Princes House</P>
    <P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-align: center">38 Jermyn Street</P>
    <P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-align: center">London, England SW1Y 6DN</P>
    <P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-align: center">+44 20 7534 1500</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.25pt 5.65pt">
    <P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-align: center">(Name, Address and Telephone Number of Person</P>
    <P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-align: center">Authorized to Receive Notices and Communications)</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding: 0.25pt 5.65pt 0.5pt; text-align: center"><FONT STYLE="font-size: 11pt">December 16, 2021</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.25pt 5.65pt">
    <P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-align: center">(Date of Event Which Requires Filing of this Statement)</P>
    <P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD></TR>
  </TABLE>
<P STYLE="font: 11pt/12pt Times New Roman, Times, Serif; margin: 0; text-align: justify">If the filing person has previously filed a statement
on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of <FONT STYLE="font-family: Playbill">&sect;&sect;</FONT>
240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box. [ ]</P>

<P STYLE="font: 11pt/12pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><B>Note</B>: Schedules filed in paper format shall
include a signed original and five copies of the schedule, including all exhibits. See <FONT STYLE="font-family: Playbill">&sect;</FONT>
240.13d-7 for other parties to whom copies are to be sent.</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-align: justify">*The remainder of this cover page shall be filled
out for a reporting person&#8217;s initial filing on this form with respect to the subject class of securities, and for any subsequent
amendment containing information which would alter disclosures provided in a prior cover page.</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-align: justify">The information required on the remainder of this
cover page shall not be deemed to be &#8220;filed&#8221; for the purpose of Section 18 of the Securities Exchange Act of 1934 (&#8220;Act&#8221;)
or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see
the Notes).</P>


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<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="9" STYLE="border-bottom: black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding: 0.25pt 5.65pt 6.5pt"><FONT STYLE="font-size: 11pt">CUSIP No. 30205M101</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="9" STYLE="padding: 6.25pt 0.25pt 6.25pt 4.3pt; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt">1. Names of Reporting Persons. I.R.S. Identification Nos. of above persons (entities only):</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt 5.65pt 0.25pt 24.25pt">
    <P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0">Abingworth LLP</P>
    <P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0">98-0518585</P></TD>
    <TD COLSPAN="5" STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="5" STYLE="padding: 6.25pt 5.65pt 0.25pt; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt">2. Check the Appropriate Box if a Member of a Group (See Instructions):</FONT></TD>
    <TD COLSPAN="2" STYLE="padding: 6.25pt 5.65pt 0.25pt; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt">(a) [ ]</FONT></TD>
    <TD COLSPAN="2" STYLE="padding: 6.25pt 5.65pt 0.25pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="5" STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt 5.65pt; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt">(b) [ ]</FONT></TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="9" STYLE="border-bottom: black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding: 6.25pt 0.25pt 6.5pt 4.3pt"><FONT STYLE="font-size: 11pt">3. SEC Use Only</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="9" STYLE="padding: 6.25pt 0.25pt 6.25pt 4.3pt; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt">4. Source of Funds (See Instructions): WC (See Item 3)</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="9" STYLE="padding: 6.25pt 0.25pt 6.25pt 4.3pt; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt">5. Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e): [ ]</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="9" STYLE="padding: 6.25pt 0.25pt 6.25pt 4.3pt; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt">6. Citizenship or Place of Organization: England</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="9" STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.25pt 5.65pt 3.25pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt 5.65pt 3.25pt; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt">Number of</FONT></TD>
    <TD COLSPAN="3" STYLE="border-bottom: black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding: 0.25pt 5.65pt 3.5pt"><FONT STYLE="font-size: 11pt">7. Sole Voting Power:</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding: 0.25pt 5.65pt 3.5pt; text-align: right"><FONT STYLE="font-size: 11pt">0 </FONT></TD>
    <TD STYLE="padding: 0.25pt 5.65pt 3.25pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.25pt 5.65pt 3.25pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt 5.65pt 3.25pt; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt">Shares Beneficially</FONT></TD>
    <TD COLSPAN="3" STYLE="border-bottom: black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding: 0.25pt 5.65pt 3.5pt"><FONT STYLE="font-size: 11pt">8. Shared Voting Power:</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding: 0.25pt 5.65pt 3.5pt; text-align: right"><FONT STYLE="font-size: 11pt">7,084,297 *</FONT></TD>
    <TD STYLE="padding: 0.25pt 5.65pt 3.25pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.25pt 5.65pt 3.25pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt 5.65pt 3.25pt; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt">Owned by</FONT></TD>
    <TD COLSPAN="3" STYLE="padding: 0.25pt 5.65pt 3.25pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt 5.65pt 3.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 5.65pt 3.25pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.25pt 5.65pt 3.25pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt 5.65pt 3.25pt; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt">Each Reporting</FONT></TD>
    <TD COLSPAN="3" STYLE="border-bottom: black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding: 0.25pt 5.65pt 3.5pt"><FONT STYLE="font-size: 11pt">9. Sole Dispositive Power:</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding: 0.25pt 5.65pt 3.5pt; text-align: right"><FONT STYLE="font-size: 11pt">0 </FONT></TD>
    <TD STYLE="padding: 0.25pt 5.65pt 3.25pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.25pt 5.65pt 3.25pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt 5.65pt 3.25pt; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt">Person With</FONT></TD>
    <TD COLSPAN="3" STYLE="border-bottom: black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding: 0.25pt 5.65pt 3.5pt"><FONT STYLE="font-size: 11pt">10. Shared Dispositive Power:</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding: 0.25pt 5.65pt 3.5pt; text-align: right"><FONT STYLE="font-size: 11pt">7,084,297 *</FONT></TD>
    <TD STYLE="padding: 0.25pt 5.65pt 3.25pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="3" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="9" STYLE="padding: 6.25pt 0.25pt 6.25pt 4.3pt; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt">11. Aggregate Amount Beneficially Owned by Each Reporting Person: 7,084,297 </FONT><FONT STYLE="font-size: 14pt"><SUP>*</SUP></FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="9" STYLE="padding: 6.25pt 0.25pt 6.25pt 4.3pt; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt">12. Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions): [ ]</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="9" STYLE="padding: 6.25pt 0.25pt 6.25pt 4.3pt; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt">13. Percent of Class Represented by Amount in Row (11): 6.5%*</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="9" STYLE="padding: 6.25pt 0.25pt 6.25pt 4.3pt; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt">14. Type of Reporting Person (See Instructions): PN</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="width: 3%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="width: 2%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="width: 38%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="width: 20%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="width: 13%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="width: 1%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="width: 13%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="width: 5%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="width: 5%; padding: 0.25pt">&nbsp;</TD></TR>
  </TABLE>
<P STYLE="font: 11pt/14pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 11pt/14pt Times New Roman, Times, Serif; margin: 0; text-align: justify">*As of the date hereof, Abingworth LLP
(&#8220;<U>Abingworth</U>&#8221;) may be deemed to beneficially own an aggregate of 7,084,297 shares of common stock, par value
$0.0001 per share (the &#8220;<U>Common Stock</U>&#8221;), of Exicure, Inc. (the &#8220;<U>Issuer</U>&#8221;) consisting of (i)
6,977,000 shares of Common Stock held by Abingworth Bioventures VII LP (&#8220;<U>ABV VII</U>&#8221;) and (ii) 107,297 shares of
Common Stock issuable upon exercise of stock options (the &#8220;Options&#8221;) issued to Dr. Bali Muralidhar. Abingworth
Bioventures VII GP LP (&#8220;<U>Abingworth GP</U>&#8221;) serves as the general partner of ABV VII. Abingworth General Partner VII
LLP, serves as the general partner of Abingworth GP. ABV VII (acting by its general partner Abingworth GP, acting by its general
partner Abingworth General Partner VII LLP) has delegated to Abingworth, all investment and dispositive power over the securities
held by ABV VII. Abingworth holds the reported securities indirectly through ABV VII. Dr. Muralidhar, a Partner of Abingworth, was
granted the Options, as director&#8217;s compensation, with respect to 115,079 shares of Common Stock. The Options are exercisable
for 107,297 shares of Common Stock within 60 days of the date hereof. Under an agreement between Dr. Muralidhar and Abingworth, Dr.
Muralidhar is deemed to hold the Options and any shares of Common Stock issuable upon exercise of the Options for the benefit of ABV
VII, and must exercise the Options solely upon the direction of Abingworth. Thus, as of the date hereof, for purposes of Rule 13d-3
under the Securities Exchange Act of 1934, as amended,Abingworth may be deemed to beneficially own 6.5% of the shares of Common
Stock deemed issued and outstanding.</P>

<P STYLE="font: 10pt/14pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><FONT STYLE="font-size: 11pt">The foregoing beneficial
ownership percentage is based upon 108,783,144 shares of Common Stock outstanding as of December 31, 2021, based on information reported
in the Issuer&#8217;s Form 8-K filed with the Securities and Exchange Commission on January 5, 2022</FONT>.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>


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<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="9" STYLE="border-bottom: black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding: 0.25pt 5.65pt 6.5pt"><FONT STYLE="font-size: 11pt">CUSIP No. 30205M101</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="9" STYLE="padding: 6.25pt 0.25pt 6.25pt 4.3pt; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt">1. Names of Reporting Persons. I.R.S. Identification Nos. of above persons (entities only):</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt 5.65pt 0.25pt 24.25pt">
    <P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0">Abingworth Bioventures VII, LP</P>
    <P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0">93-1331173</P></TD>
    <TD COLSPAN="5" STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="5" STYLE="padding: 6.25pt 5.65pt 0.25pt; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt">2. Check the Appropriate Box if a Member of a Group (See Instructions):</FONT></TD>
    <TD COLSPAN="2" STYLE="padding: 6.25pt 5.65pt 0.25pt; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt">(a) [ ]</FONT></TD>
    <TD COLSPAN="2" STYLE="padding: 6.25pt 5.65pt 0.25pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="5" STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt 5.65pt; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt">(b) [ ]</FONT></TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="9" STYLE="border-bottom: black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding: 6.25pt 0.25pt 6.5pt 4.3pt"><FONT STYLE="font-size: 11pt">3. SEC Use Only</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="9" STYLE="padding: 6.25pt 0.25pt 6.25pt 4.3pt; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt">4. Source of Funds (See Instructions): WC (See Item 3)</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="9" STYLE="padding: 6.25pt 0.25pt 6.25pt 4.3pt; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt">5. Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e): [ ]</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="9" STYLE="padding: 6.25pt 0.25pt 6.25pt 4.3pt; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt">6. Citizenship or Place of Organization: England</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="9" STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.25pt 5.65pt 3.25pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt 5.65pt 3.25pt; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt">Number of</FONT></TD>
    <TD COLSPAN="3" STYLE="border-bottom: black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding: 0.25pt 5.65pt 3.5pt"><FONT STYLE="font-size: 11pt">7. Sole Voting Power:</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding: 0.25pt 5.65pt 3.5pt; text-align: right"><FONT STYLE="font-size: 11pt">0 </FONT></TD>
    <TD STYLE="padding: 0.25pt 5.65pt 3.25pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.25pt 5.65pt 3.25pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt 5.65pt 3.25pt; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt">Shares Beneficially</FONT></TD>
    <TD COLSPAN="3" STYLE="border-bottom: black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding: 0.25pt 5.65pt 3.5pt"><FONT STYLE="font-size: 11pt">8. Shared Voting Power:</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding: 0.25pt 5.65pt 3.5pt; text-align: right"><FONT STYLE="font-size: 11pt">7,084,297*</FONT></TD>
    <TD STYLE="padding: 0.25pt 5.65pt 3.25pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.25pt 5.65pt 3.25pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt 5.65pt 3.25pt; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt">Owned by</FONT></TD>
    <TD COLSPAN="3" STYLE="padding: 0.25pt 5.65pt 3.25pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt 5.65pt 3.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 5.65pt 3.25pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.25pt 5.65pt 3.25pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt 5.65pt 3.25pt; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt">Each Reporting</FONT></TD>
    <TD COLSPAN="3" STYLE="border-bottom: black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding: 0.25pt 5.65pt 3.5pt"><FONT STYLE="font-size: 11pt">9. Sole Dispositive Power:</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding: 0.25pt 5.65pt 3.5pt; text-align: right"><FONT STYLE="font-size: 11pt">0 </FONT></TD>
    <TD STYLE="padding: 0.25pt 5.65pt 3.25pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.25pt 5.65pt 3.25pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt 5.65pt 3.25pt; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt">Person With</FONT></TD>
    <TD COLSPAN="3" STYLE="border-bottom: black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding: 0.25pt 5.65pt 3.5pt"><FONT STYLE="font-size: 11pt">10. Shared Dispositive Power:</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding: 0.25pt 5.65pt 3.5pt; text-align: right"><FONT STYLE="font-size: 11pt">7,084,297*</FONT></TD>
    <TD STYLE="padding: 0.25pt 5.65pt 3.25pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="3" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="9" STYLE="padding: 6.25pt 0.25pt 6.25pt 4.3pt; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt">11. Aggregate Amount Beneficially Owned by Each Reporting Person: 7,084,297</FONT><FONT STYLE="font-size: 14pt"><SUP>*</SUP></FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="9" STYLE="padding: 6.25pt 0.25pt 6.25pt 4.3pt; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt">12. Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions): [ ]</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="9" STYLE="padding: 6.25pt 0.25pt 6.25pt 4.3pt; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt">13. Percent of Class Represented by Amount in Row (11): 6.5%*</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="9" STYLE="padding: 6.25pt 0.25pt 6.25pt 4.3pt; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt">14. Type of Reporting Person (See Instructions): PN</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 5.65pt 0.5pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="width: 3%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="width: 2%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="width: 38%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="width: 20%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="width: 13%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="width: 1%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="width: 13%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="width: 5%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="width: 5%; padding: 0.25pt">&nbsp;</TD></TR>
  </TABLE>
<P STYLE="font: 11pt/14pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 11pt/14pt Times New Roman, Times, Serif; margin: 0; text-align: justify">*Consists of 6,977,000 shares of common
stock, par value $0.0001 per share (the &#8220;Common Stock&#8221;) held directly by Abingworth Bioventures VII LP (&#8220;<U>ABV
VII</U>&#8221;) and 107,297 shares of Common Stock underlying the stock options (the &#8220;Options&#8221;) held by Dr. Muralidhar
which are exercisable within 60 days of the date hereof. Under an agreement between Dr. Muralidhar and Abingworth LLP
(&#8220;<U>Abingworth</U>&#8221;), Dr. Muralidhar is deemed to hold the Options and any shares of Common Stock issuable upon
exercise of the Options for the benefit of ABV VII, and must exercise the Options solely upon the direction of Abingworth. As of the
date hereof, for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended, ABV VII may be deemed to beneficially
own 6.5% of the shares of Common Stock deemed issued and outstanding.</P>

<P STYLE="font: 10pt/14pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><FONT STYLE="font-size: 11pt">The foregoing beneficial
ownership percentage is based upon 108,783,144 shares of Common Stock outstanding as of December 31, 2021 based on information reported
in the Issuer&#8217;s Form 8-K filed with the Securities and Exchange Commission on January 5, 2022</FONT>.</P>


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<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 99%">
    <P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 6pt 0 0; text-align: center"><B>Explanatory Note</B></P>
    <P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 6pt 0 0; text-align: center">&nbsp;</P>
    <P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 1in">This Amendment No. 1 (this &#8220;<U>Amendment</U>&#8221;)
    amends and supplements the Schedule 13D filed on behalf of the Reporting Persons with the Securities and Exchange Commission on August
    9, 2019 (the &#8220;<U>Schedule 13D</U>&#8221;). Except as specifically provided herein, this Amendment does not modify or amend any of
    the information previously reported in the Schedule 13D. Capitalized terms used and not otherwise defined herein shall have the meanings
    ascribed to such terms in the Schedule 13D. Information given in response to each item shall be deemed incorporated by reference in all
    other items, as applicable.</P>
    <P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 1in">&nbsp;</P>
    <P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-align: justify">Item 1. &#9;<U>Security and Issuer</U></P>
    <P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>
    <P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-align: justify">Item 1 of the Schedule 13D is amended and restated
    as follows:</P></TD>
    <TD STYLE="width: 1%">&nbsp;</TD></TR>
  </TABLE>
  <P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 1in">This Schedule 13D relates to
the common stock, par value $0.0001 per share (the &ldquo;Common Stock&rdquo;), of Exicure, Inc., a Delaware corporation (the
&#8220;<U>Issuer</U>&#8221;). The Issuer&#8217;s principal executive offices are located at 2430 N. Halsted Street, Chicago, IL
60614.</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 0px">&nbsp;</TD>
    <TD STYLE="width: 96px; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt">Item 5.</FONT></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt"><U>Interest in Securities of the Issuer</U></FONT></TD></TR>
  </TABLE>
<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 96px; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt">&nbsp;Item 5 of the Schedule 13D is amended and restated as follows:</FONT></TD>
    </TR>
  </TABLE>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 1in">As of the date hereof,
Abingworth LLP (&#8220;<U>Abingworth</U>&#8221;) may be deemed to beneficially own an aggregate of 7,084,297 shares of Common Stock of Exicure, Inc. (the &#8220;<U>Issuer</U>&#8221;) consisting of (i) 6,977,000 shares of Common Stock
held by Abingworth Bioventures VII LP (&#8220;<U>ABV VII</U>&#8221;) and (ii) 107,297 shares of Common Stock issuable upon exercise
of stock options (the &#8220;Options&#8221;) issued to Dr. Bali Muralidhar. Dr. Muralidhar is a Partner of Abingworth. Under an
agreement between Dr. Muralidhar and Abingworth, Dr. Muralidhar is deemed to hold the Options and any shares of Common Stock
issuable upon exercise of the Options for the benefit of ABV VII, and must exercise the Options solely upon the direction of
Abingworth. As a result, for purposes of Rule 13d-3 under the Securities Exchange Act each of ABV VII and Abingworth may be deemed
to beneficially own the shares of Common Stock and the 107,297 shares of Common Stock underlying the Options held by Dr. Muralidhar
which are exercisable within 60 days of the date hereof. Neither ABV VII nor Abingworth directly owns any of the shares of Common
Stock underlying the Options.</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 1in">As a result of the foregoing, Abingworth,
as the investment manager of ABV VII, may be deemed to beneficially own (i) the 6,977,000 shares of Common Stock held by ABV VII and (ii)
the 107,297 shares of Common Stock issuable upon exercise of the Options. Thus, for purposes of Rule 13d-3 under the Securities Exchange
Act of 1934, as amended, Abingworth may be deemed to beneficially own 6.5% of the shares of Common Stock of the Issuer deemed issued and
outstanding as of the date hereof.</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 1in">The foregoing beneficial ownership
percentage is based upon 108,783,144 shares of Common Stock outstanding as of December 31, 2021 based on information reported in the Issuer&#8217;s
Form 8-K filed with the Securities and Exchange Commission on January 5, 2022.</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 1in">Except as described herein, during
the past sixty (60) days on or prior to the date hereof, there were no other purchases or sales of shares of Common Stock, or securities
convertible into or exchangeable for shares of Common Stock, by the Reporting Persons or any person or entity for which the Reporting
Persons possess voting or dispositive control over the securities thereof.</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 0px">&nbsp;</TD>
    <TD STYLE="width: 96px; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt">Item 7.</FONT></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: justify"><FONT STYLE="font-size: 11pt"><U>Material to be Filed as Exhibits</U></FONT></TD></TR>
  </TABLE>
<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 0 0.5in; text-align: justify; text-indent: 0.5in">The following exhibit
is incorporated into this Schedule 13D:</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

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    <TD STYLE="width: 15%; padding: 0.25pt 5.65pt; font: 12pt Times New Roman, Times, Serif; text-align: justify"><FONT STYLE="font-size: 11pt">&nbsp;&nbsp;Exhibit 1</FONT></TD>
    <TD STYLE="width: 73%; padding: 0.25pt 5.65pt; font: 12pt Times New Roman, Times, Serif; text-align: justify"><FONT STYLE="font-size: 11pt">Joint Filing Agreement, dated August 9, 2019, signed by each of the Reporting Persons (incorporated by reference to Exhibit 1 to the Schedule 13D filed with the Securities and Exchange Commission on August 9, 2019)</FONT></TD></TR>
  </TABLE>

<P STYLE="font: 11pt/115% Times New Roman, Times, Serif; margin: 12pt 0 10pt; text-align: center"><B>&nbsp;</B></P>


<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0"><B>&nbsp;</B></P>

<P STYLE="font: 11pt/115% Times New Roman, Times, Serif; margin: 12pt 0 10pt; text-align: center"><B><U>Signature</U></B></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in">After reasonable inquiry
and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.</P>

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    <TD STYLE="padding: 0.25pt 5.65pt; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt">Dated: February 25, 2022</FONT></TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD></TR>
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    <TD STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD></TR>
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    <TD COLSPAN="2" STYLE="padding: 0.25pt 5.65pt; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt"><B>ABINGWORTH BIOVENTURES VII, LP</B></FONT></TD>
    <TD STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD></TR>
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    <TD STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD></TR>
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    <TD STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt 5.65pt">
    <P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0">By: Abingworth LLP, its Manager</P>
    <P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P></TD>
    <TD STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 43%; padding: 0.25pt 5.65pt">&nbsp;</TD>
    <TD STYLE="width: 5%; padding: 0.25pt 5.65pt; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt">By:</FONT></TD>
    <TD STYLE="width: 47%; border-bottom: black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding: 0.25pt 5.65pt 0.5pt"><FONT STYLE="font-size: 11pt">/s/ John Heard</FONT></TD>
    <TD STYLE="width: 5%; padding: 0.25pt 5.65pt">&nbsp;</TD></TR>
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    <TD STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 5.65pt; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt">Name: John Heard</FONT></TD>
    <TD STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD></TR>
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    <TD STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 5.65pt">
    <P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0">Title: Authorized Signatory</P>
    <P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P></TD>
    <TD STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD></TR>
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    <TD STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt 5.65pt; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt"><B>ABINGWORTH, LLP</B></FONT></TD>
    <TD STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD></TR>
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    <TD STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD>
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    <TD STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 5.65pt; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt">By:</FONT></TD>
    <TD STYLE="border-bottom: black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding: 0.25pt 5.65pt 0.5pt"><FONT STYLE="font-size: 11pt">/s/ John Heard</FONT></TD>
    <TD STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 5.65pt; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 11pt">Name: John Heard</FONT></TD>
    <TD STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt 5.65pt">
    <P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0">Title: Authorized Signatory</P>
    <P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P></TD>
    <TD STYLE="padding: 0.25pt 5.65pt">&nbsp;</TD></TR>
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<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Attention: Intentional misstatements or omissions
of fact constitute<BR>
Federal criminal violations (See 18 U.S.C. 1001).</B></P>

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