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Shareholders' Equity (Deficit) - outstanding warrants (Details) - American Depositary Shares - $ / shares	3 Months Ended	12 Months Ended
	Mar. 31, 2025	Dec. 31, 2024
Class of Warrant or Right [Line Items]
Equity-classified Warrants	3,519,566	3,519,566
Liability-classified Warrants	11,191,776	6,788,077
Warrants exercised	14,711,342	10,307,643
October 2023 Investor Prefunded Warrants
Class of Warrant or Right [Line Items]
Equity-classified Warrants	48,387	48,387
Weighted-Average Exercise Price	$ 0.2
March 2025 Series A Investor Warrants
Class of Warrant or Right [Line Items]
Equity-classified Warrants	2,283,031	0
Weighted-Average Exercise Price	$ 0.87
March 2030 Series B Investor Warrants
Class of Warrant or Right [Line Items]
Equity-classified Warrants	2,283,031	0
Weighted-Average Exercise Price	$ 0.87
May 2024 Investor Warrants
Class of Warrant or Right [Line Items]
Equity-classified Warrants	4,029,754	4,029,754
Weighted-Average Exercise Price	$ 1.77
March 2024 Placement Agent Warrants
Class of Warrant or Right [Line Items]
Equity-classified Warrants	132,061	132,061
Weighted-Average Exercise Price	$ 1.85
May 2024 Placement Agent Warrants [Member]
Class of Warrant or Right [Line Items]
Equity-classified Warrants	322,380	322,380
Weighted-Average Exercise Price	$ 1.89
November 2024 Investor Warrants
Class of Warrant or Right [Line Items]
Equity-classified Warrants	1,713,402	1,713,402
Weighted-Average Exercise Price	$ 2.26
October 2023 Placement Agent Warrants
Class of Warrant or Right [Line Items]
Equity-classified Warrants	42,550	42,550
Weighted-Average Exercise Price	$ 4.13
March 2022 Investor Warrants
Class of Warrant or Right [Line Items]
Equity-classified Warrants	186,007	186,007
Weighted-Average Exercise Price	$ 28
March 2022 Placement Agent Warrants
Class of Warrant or Right [Line Items]
Equity-classified Warrants	14,874	14,874
Weighted-Average Exercise Price	$ 30
December 2021 Investor Warrants
Class of Warrant or Right [Line Items]
Equity-classified Warrants	107,775	107,775
Weighted-Average Exercise Price	$ 33
December 2021 Placement Agent Warrants
Class of Warrant or Right [Line Items]
Equity-classified Warrants	8,615	8,615
Weighted-Average Exercise Price	$ 35
2020 Investor Warrants
Class of Warrant or Right [Line Items]
Equity-classified Warrants	0	139,882
Weighted-Average Exercise Price	$ 44
July 2021 Placement Agent Warrants
Class of Warrant or Right [Line Items]
Equity-classified Warrants	19,909	19,909
Weighted-Average Exercise Price	$ 46.4
2020 Placement Warrants
Class of Warrant or Right [Line Items]
Equity-classified Warrants	0	22,481
Weighted-Average Exercise Price	$ 51
April 2023 Peak Bio Warrants
Class of Warrant or Right [Line Items]
Liability-classified Warrants	1,187,013	1,187,013
Weighted-Average Exercise Price	$ 2.04
November 2022 Peak Bio Warrants
Class of Warrant or Right [Line Items]
Liability-classified Warrants	1,577,556	1,577,556
Weighted-Average Exercise Price	$ 39.18
Series B warrants | September 2022 Investor Warrants
Class of Warrant or Right [Line Items]
Liability-classified Warrants	754,997	754,997
Weighted-Average Exercise Price	$ 17

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+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 3
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481112/505-10-50-3

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