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RELATED PARTY TRANSACTIONS (Details Narrative) - USD ($) |  | 12 Months Ended
--- | --- | ---
May 10, 2021 | Dec. 31, 2021 | Dec. 31, 2020 | Dec. 20, 2018
Shares issued |  | 17,544,509 | 13,485,128 |
Accrued interest |  | $ 1,019,889 | $ 742,374 |
Revenue |  | 56,239,667 | 55,406,337 |
Grigorios Siokas Three [Member] |  |  |  |
Borrowing |  | 2,040,635 |  |
Outstanding principal balance |  | 1,293,472 | 1,629,246 |
Additional proceeds from debt |  | 275,306 |  |
Repayment of loans |  | 133,552 |  |
Foreign curreny translation |  | $ 20,623 | 27,114 |
Debt instrument conversion price |  | $ 6.00 |  |
Convertible share description |  | Mr. Siokas whereby the Company exchanged an aggregate total of $6,000,000 of debt into 1,000,000 shares of Common Stock at above market prices. |  |
Debt instrument converted amount |  | $ 2,250,000 |  |
Shares issued |  | 375,000 |  |
Grigorios Siokas [Member] |  |  |  |
Borrowing |  |  |  | $ 1,718,400
Outstanding principal balance |  | $ 452,720 | 489,200 |
Accrued interest |  | 200,683 | 193,585 |
Interest rate |  |  |  | 4.70%
Maturity date |  |  |  | Mar. 18, 2019
Litigation settlement | $ 600,000 |  |  |
Plantiff attorney fees | 120,000 |  |  |
Litigation cost | $ 4,137 |  |  |
Dimitrios Goulielmos [Member] |  |  |  |
Outstanding principal balance |  | 11,544 | 12,475 |
DOC Pharma S.A. [Member] |  |  |  |
Foreign curreny translation |  | 37,411 | 122,279 |
Payments to purchase products |  | 3,084,805 | 5,983,809 |
Accounts payable balance |  | 565,756 |  |
Accounts receivable balance |  | 2,901,300 | 3,468,653 |
Prepaid balance |  | 3,263,241 | 3,468,564 |
Revenue |  | $ 978,321 | $ 2,843,260 |
Agreement term |  | 5 years |  |
Pieces per product |  | 1,000 pieces |  |
Inventroy purchase |  | $ 2,010,517 |  |
Description of research and development |  | Design & Development (€725,000); Control and Product Manufacturing (€250,000) and Clinical Study and Research (€450,000). In the year ended December 31, 2021, SkyPharm bought 67 licenses at value of €261,300 ($295,739) from Doc Pharma which was the 18.33% of the total cost. The agreement will be terminated on December 31, 2025 |  |

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