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RELATED PARTY TRANSACTIONS (Details Narrative) - USD ($) |  |  | 3 Months Ended | 12 Months Ended
--- | --- | --- | --- | ---
May 10, 2021 | Oct. 10, 2020 | Mar. 31, 2022 | Mar. 31, 2021 | Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2020 | Dec. 20, 2018 | Dec. 20, 2018
Revenue |  |  | $ 13,071,800 | $ 11,619,076 | $ 56,239,667 | $ 55,406,337 |  |  |
Foreign curreny translation |  |  | 13,106 |  | 423,245 |  |  |  |
Accrued interest |  |  | 1,033,866 |  | 1,019,889 | 742,374 | $ 742,374 |  |
Net income (loss) |  |  | 203,347 | (2,173,903) | $ (7,961,649) | $ 820,786 | $ 820,786 |  |
Shares issued |  |  |  |  | 17,544,509 | 13,485,128 | 13,485,128 |  |
DOC Pharma S.A. [Member] |  |  |  |  |  |  |  |  |
Prepaid balance |  |  | 4,368,794 |  | $ 3,263,241 | $ 3,468,653 | $ 3,468,653 |  |
Accounts payable balance |  |  | 220,518 |  | 565,756 |  |  |  |
Net prepaid balance |  |  | 4,148,276 |  |  |  |  |  |
Accounts receivable balance |  |  | 2,844,572 |  | 2,901,300 | 3,468,564 | 3,468,564 |  |
Payments to purchase products |  |  | 687,382 | 589,261 | 3,084,805 | 5,983,809 |  |  |
Revenue |  |  | $ 383,688 | $ 290,598 | $ 978,321 | 2,843,260 |  |  |
Description of research and development |  |  | Design & Development (€725,000); Control and Product Manufacturing (€250,000) and Clinical Study and Research (€450,000). In the year ended December 31, 2021, SkyPharm bought 67 licenses at value of €261,300 ($289,860) from Doc Pharma which was the 18.33% of the total cost. The agreement will be terminated on December 31, 2025. |  | Design & Development (€725,000); Control and Product Manufacturing (€250,000) and Clinical Study and Research (€450,000). In the year ended December 31, 2021, SkyPharm bought 67 licenses at value of €261,300 ($295,739) from Doc Pharma which was the 18.33% of the total cost. The agreement will be terminated on December 31, 2025. |  |  |  |
Foreign curreny translation |  |  |  |  | $ 37,411 | 122,279 |  |  |
Pieces per product |  |  |  |  | 1,000 pieces |  |  |  |
Inventroy purchase |  |  |  |  | $ 2,010,517 |  |  |  |
DOC Pharma S.A. [Member] | Outsourcing Agreement [Member] |  |  |  |  |  |  |  |  |
Pieces per product |  | 1,000 |  |  |  |  |  |  |
Inventroy purchase |  |  | $ 517,566 |  |  |  |  |  |
Agreement term |  | 5 years |  |  |  |  |  |  |
Grigorios Siokas [Member] |  |  |  |  |  |  |  |  |
Interest rate |  |  |  |  |  |  |  | 4.70% | 4.70%
Accrued interest |  |  | 201,835 |  | 200,683 | 193,585 | 193,585 |  |
Outstanding principal balance |  |  | 443,720 |  | 452,720 | 489,200 | 489,200 |  |
Borrowing |  |  |  |  |  |  |  | $ 1,718,400 | $ 1,718,400
Maturity date |  |  |  |  |  |  |  | Mar. 18, 2019 |
Litigation settlement | $ 600,000 |  |  |  |  |  |  |  |
Plantiff attorney fees | 120,000 |  |  |  |  |  |  |  |
Litigation cost | $ 4,137 |  |  |  |  |  |  |  |
Dimitrios Goulielmos [Member] |  |  |  |  |  |  |  |  |
Outstanding principal balance |  |  | 11,315 |  | 11,544 | 12,475 | 12,475 |  |
Gain incured |  |  | 9,229 |  |  |  |  |  |
Grigorios Siokas Three [Member] |  |  |  |  |  |  |  |  |
Foreign curreny translation |  |  |  |  | 20,623 | 27,114 |  |  |
Outstanding principal balance |  |  |  |  | 1,293,472 | $ 1,629,246 | $ 1,629,246 |  |
Borrowing |  |  |  |  | 2,040,635 |  |  |  |
Additional proceeds from debt |  |  | 356,085 |  | 275,306 |  |  |  |
Repayment of loans |  |  | 22,186 |  | $ 133,552 |  |  |  |
Net income (loss) |  |  | 23,490 |  |  |  |  |  |
Debt instrument conversion price |  |  |  |  | $ 6.00 |  |  |  |
Convertible share description |  |  |  |  | Mr. Siokas whereby the Company exchanged an aggregate total of $6,000,000 of debt into 1,000,000 shares of Common Stock at above market prices. |  |  |  |
Debt instrument converted amount |  |  |  |  | $ 2,250,000 |  |  |  |
Shares issued |  |  |  |  | 375,000 |  |  |  |
Grigorios Siokas Four [Member] |  |  |  |  |  |  |  |  |
Additional proceeds from debt |  |  | $ 100,000 |  |  |  |  |  |

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