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Commitment and Contingencies - Additional Information (Details) - USD ($) | 1 Months Ended |  |  |
--- | --- | --- | --- | ---
Jun. 30, 2018 | Mar. 31, 2018 | Apr. 30, 2017 | Dec. 31, 2016 | Dec. 31, 2017 | Jun. 30, 2016 | Nov. 18, 2015
Other Commitments [Line Items] |  |  |  |  |  |  |
Purchase obligation | $ 2,397,000 |  |  |  | $ 599,000 | $ 2,923,000 |
Pfizer License Agreement | Minimum |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Potential future regulatory milestone and sales milestone payments upon achievement of net sales |  |  |  |  |  |  | $ 250,000,000
Pfizer License Agreement | Maximum |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Potential future regulatory milestone and sales milestone payments upon achievement of net sales |  |  |  |  |  |  | $ 1,000,000,000
Supplemental Agreement |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Purchase obligation | $ 2,397,000 |  |  |  |  |  |
Commercial Unit Lease Agreement | Dublin |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Operating lease agreement, term of contract | 20 years |  |  |  |  |  |
Operating lease agreement, break option term of contract | 10 years |  |  |  |  |  |
Operating lease agreement, commencement period | 2018-06 |  |  |  |  |  |
Annual lease payments | $ 321,000 |  |  |  |  |  |
Operating lease agreement, rental review | 5 years |  |  |  |  |  |
Security deposit | $ 818,000 |  |  |  |  |  |
Office Space Lease Agreement | Dublin |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Operating lease agreement, term of contract |  |  |  | 10 years |  |  |
Annual lease payments |  |  |  | $ 375,000 |  |  |
Operating lease agreement, renewal term |  |  |  | 5 years |  |  |
Operating lease agreement, commencement date |  |  |  | Dec. 01, 2016 |  |  |
Operating lease agreement, expiration date |  |  |  | Dec. 01, 2026 |  |  |
Operating lease agreement, review period |  |  |  | 2022-12 |  |  |
Office Space Lease Agreement | Dublin | Other Assets |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Security deposit |  |  |  | $ 338,000 |  |  |
Office Space Lease Agreement | Chicago |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Operating lease agreement, term of contract |  | 5 years |  |  |  |  |
Operating lease agreement, commencement period |  | 2018-06 |  |  |  |  |
Annual lease payments |  | $ 258,000 |  |  |  |  |
Security deposit |  | $ 120,000 |  |  |  |  |
Operating lease agreement, renewal term |  | 5 years |  |  |  |  |
Office Space Lease Agreement | Connecticut |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Operating lease agreement, term of contract |  |  | 5 years |  |  |  |
Operating lease agreement, commencement period |  |  | 2017-07 |  |  |  |
Annual lease payments |  |  | $ 131,000 |  |  |  |
Operating lease agreement, renewal term |  |  | 3 years |  |  |  |
Office Space Lease Agreement | Connecticut | Other Assets |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Security deposit |  |  | $ 17,000 |  |  |  |

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