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Shareholders' Equity - Reconciliation of Beginning and Ending Balances in Shareholders' Equity (Details) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended | 12 Months Ended
--- | --- | --- | ---
Jun. 30, 2018 | Jun. 30, 2017 | Jun. 30, 2018 | Jun. 30, 2017 | Dec. 31, 2017
Class Of Stock [Line Items] |  |  |  |  |
Shareholders' equity, Beginning Balance |  |  | $ 39,494 | $ 22,668 | $ 22,668
Conversion of preferred shares to ordinary shares |  |  | 74 |  |
Share-based compensation expense |  |  | 404 | 180 |
Issuance of warrants |  |  | 139 |  |
Net loss | $ (15,747) | $ (6,280) | (27,893) | (12,117) | (29,406)
Shareholders' equity, Ending Balance | $ 118,530 | $ 56,571 | 118,530 | 56,571 | $ 39,494
Series B Convertible Preferred Shares |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |
Issuance of shares |  |  | 32,159 | $ 45,840 |
Ordinary Shares |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |
Issuance of shares |  |  | $ 74,153 |  |

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